BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

122 related articles for article (PubMed ID: 12604232)

  • 1. Stereochemical aspects of carbonyl reduction of the original anticancer drug oracin by mouse liver microsomes and purified 11beta-hydroxysteroid dehydrogenase type 1.
    Wsól V; Szotáková B; Skálová L; Maser E
    Chem Biol Interact; 2003 Feb; 143-144():459-68. PubMed ID: 12604232
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The novel anticancer drug oracin: different stereospecificity and cooperativity for carbonyl reduction by purified human liver 11beta-hydroxysteroid dehydrogenase type 1.
    Wsól V; Szotáková B; Skálová L; Maser E
    Toxicology; 2004 May; 197(3):253-61. PubMed ID: 15033547
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Partial purification and characterization of a new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin.
    Skarydová L; Skarka A; Novotná R; Zivná L; Martin HJ; Wsól V; Maser E
    Toxicology; 2009 Oct; 264(1-2):52-60. PubMed ID: 19635524
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Aldo-keto reductases (AKR) from the AKR1C subfamily catalyze the carbonyl reduction of the novel anticancer drug oracin in man.
    Wsol V; Szotakova B; Martin HJ; Maser E
    Toxicology; 2007 Sep; 238(2-3):111-8. PubMed ID: 17618725
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Reduction of the potential anticancer drug oracin in the rat liver in-vitro.
    Szotáková B; Skálová L; Wsól V; Kvasniècková E
    J Pharm Pharmacol; 2000 May; 52(5):495-500. PubMed ID: 10864136
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A comparison between stereospecificity of oracin reduction and stereoselectivity of oxidation of 11-dihydrooracin enantiomers in vitro in rat and guinea pig.
    Skálová L; Wsól V; Szotáková B; Kvasnicková E
    Chirality; 1999; 11(5-6):510-5. PubMed ID: 10368925
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Stereospecific reduction of the original anticancer drug oracin in rat extrahepatic tissues.
    Szotáková B; Skálová L; Jílek P; Buchta V; Wsól V
    J Pharm Pharmacol; 2003 Jul; 55(7):1003-11. PubMed ID: 12906758
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 11Beta-hydroxysteroid dehydrogenase responsible for carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes.
    Maser E
    Cancer Res; 1998 Jul; 58(14):2996-3003. PubMed ID: 9679962
    [TBL] [Abstract][Full Text] [Related]  

  • 9. High-performance liquid chromatography study of stereospecific microsomal enzymes catalysing the reduction of a potential cytostatic drug, oracin. Interspecies comparison.
    Wsól V; Szotáková B; Kvasnicková E; Fell AF
    J Chromatogr A; 1998 Feb; 797(1-2):197-201. PubMed ID: 9542111
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The main metabolic pathway of oracin, a new potential cytostatic drug, in human liver microsomes and cytosol: stereoselectivity of reoxidation of the principal metabolite 11-dihydrooracin to oracin.
    Wsól V; Szotáková B; Skálová L; Cepková H; Kvasnicková E
    Enantiomer; 2000; 5(3-4):263-70. PubMed ID: 11126866
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Sex differences in stereospecificity of oracin reductases in rat in vitro and in vivo.
    Wsól V; Skálová L; Szotáková B; Trejtnar F; Kvasnicková E
    Chirality; 1999; 11(5-6):505-9. PubMed ID: 10368924
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Purification, characterization and NNK carbonyl reductase activities of 11beta-hydroxysteroid dehydrogenase type 1 from human liver: enzyme cooperativity and significance in the detoxification of a tobacco-derived carcinogen.
    Maser E; Friebertshäuser J; Völker B
    Chem Biol Interact; 2003 Feb; 143-144():435-48. PubMed ID: 12604230
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 11 beta-hydroxysteroid dehydrogenase mediates reductive metabolism of xenobiotic carbonyl compounds.
    Maser E; Bannenberg G
    Biochem Pharmacol; 1994 May; 47(10):1805-12. PubMed ID: 8204097
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 11 Beta-hydroxysteroid dehydrogenase type 1 from human liver: dimerization and enzyme cooperativity support its postulated role as glucocorticoid reductase.
    Maser E; Völker B; Friebertshäuser J
    Biochemistry; 2002 Feb; 41(7):2459-65. PubMed ID: 11841241
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Heterogeneity of 11beta-hydroxysteroid dehydrogenase type 1/microsomal carbonyl reductase (11beta-HSD/CR) in guinea pig tissues. Purification of the liver form suggests modification in the cosubstrate binding site.
    Oppermann UC; Möbus E; Nagel G; Maser E
    Toxicology; 2000 Apr; 144(1-3):63-9. PubMed ID: 10781872
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Purification and characterization of hamster liver microsomal 7alpha-hydroxycholesterol dehydrogenase. Similarity to type I 11beta-hydroxysteroid dehydrogenase.
    Song W; Chen J; Dean WL; Redinger RN; Prough RA
    J Biol Chem; 1998 Jun; 273(26):16223-8. PubMed ID: 9632680
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In the search for specific inhibitors of human 11beta-hydroxysteroid-dehydrogenases (11beta-HSDs): chenodeoxycholic acid selectively inhibits 11beta-HSD-I.
    Diederich S; Grossmann C; Hanke B; Quinkler M; Herrmann M; Bähr V; Oelkers W
    Eur J Endocrinol; 2000 Feb; 142(2):200-7. PubMed ID: 10664531
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Enantioselectivity of carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by tissue fractions from human and rat and by enzymes isolated from human liver.
    Breyer-Pfaff U; Martin HJ; Ernst M; Maser E
    Drug Metab Dispos; 2004 Sep; 32(9):915-22. PubMed ID: 15319331
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The purification of 11 beta-hydroxysteroid dehydrogenase from mouse liver microsomes.
    Maser E; Bannenberg G
    J Steroid Biochem Mol Biol; 1994 Feb; 48(2-3):257-63. PubMed ID: 7511408
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in cytosol of mouse liver and lung.
    Atalla A; Maser E
    Toxicology; 1999 Nov; 139(1-2):155-66. PubMed ID: 10614696
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.