141 related articles for article (PubMed ID: 12604236)
1. Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone.
Higaki Y; Usami N; Shintani S; Ishikura S; El-Kabbani O; Hara A
Chem Biol Interact; 2003 Feb; 143-144():503-13. PubMed ID: 12604236
[TBL] [Abstract][Full Text] [Related]
2. Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines.
Usami N; Yamamoto T; Shintani S; Ishikura S; Higaki Y; Katagiri Y; Hara A
Biol Pharm Bull; 2002 Apr; 25(4):441-5. PubMed ID: 11995921
[TBL] [Abstract][Full Text] [Related]
3. Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.
Penning TM; Burczynski ME; Jez JM; Hung CF; Lin HK; Ma H; Moore M; Palackal N; Ratnam K
Biochem J; 2000 Oct; 351(Pt 1):67-77. PubMed ID: 10998348
[TBL] [Abstract][Full Text] [Related]
4. Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1.
Brozic P; Smuc T; Gobec S; Rizner TL
Mol Cell Endocrinol; 2006 Oct; 259(1-2):30-42. PubMed ID: 16962702
[TBL] [Abstract][Full Text] [Related]
5. Derivatives of pyrimidine, phthalimide and anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1.
Brozic P; Cesar J; Kovac A; Davies M; Johnson AP; Fishwick CW; Lanisnik Rizner T; Gobec S
Chem Biol Interact; 2009 Mar; 178(1-3):158-64. PubMed ID: 19007763
[TBL] [Abstract][Full Text] [Related]
6. Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.
Ji Q; Aoyama C; Nien YD; Liu PI; Chen PK; Chang L; Stanczyk FZ; Stolz A
Cancer Res; 2004 Oct; 64(20):7610-7. PubMed ID: 15492289
[TBL] [Abstract][Full Text] [Related]
7. Inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1).
El-Kabbani O; Dhagat U; Hara A
J Steroid Biochem Mol Biol; 2011 May; 125(1-2):105-11. PubMed ID: 21050889
[TBL] [Abstract][Full Text] [Related]
8. Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).
Penning TM; Burczynski ME; Jez JM; Lin HK; Ma H; Moore M; Ratnam K; Palackal N
Mol Cell Endocrinol; 2001 Jan; 171(1-2):137-49. PubMed ID: 11165022
[TBL] [Abstract][Full Text] [Related]
9. Activity and expression of progesterone metabolizing 5alpha-reductase, 20alpha-hydroxysteroid oxidoreductase and 3alpha(beta)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells.
Wiebe JP; Lewis MJ
BMC Cancer; 2003 Mar; 3():9. PubMed ID: 12659654
[TBL] [Abstract][Full Text] [Related]
10. Porcine aldo-keto reductase 1C subfamily members AKR1C1 and AKR1C4: Substrate specificity, inhibitor sensitivity and activators.
Endo S; Morikawa Y; Matsunaga T; Hara A; Nishinaka T
J Steroid Biochem Mol Biol; 2022 Jul; 221():106113. PubMed ID: 35398259
[TBL] [Abstract][Full Text] [Related]
11. Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1).
El-Kabbani O; Scammells PJ; Gosling J; Dhagat U; Endo S; Matsunaga T; Soda M; Hara A
J Med Chem; 2009 May; 52(10):3259-64. PubMed ID: 19397269
[TBL] [Abstract][Full Text] [Related]
12. Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.
Lewis MJ; Wiebe JP; Heathcote JG
BMC Cancer; 2004 Jun; 4():27. PubMed ID: 15212687
[TBL] [Abstract][Full Text] [Related]
13. A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase.
Dhagat U; Carbone V; Chung RP; Matsunaga T; Endo S; Hara A; El-Kabbani O
Med Chem; 2007 Nov; 3(6):546-50. PubMed ID: 18045204
[TBL] [Abstract][Full Text] [Related]
14. Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors.
El-Kabbani O; Scammells PJ; Day T; Dhagat U; Endo S; Matsunaga T; Soda M; Hara A
Eur J Med Chem; 2010 Nov; 45(11):5309-17. PubMed ID: 20850205
[TBL] [Abstract][Full Text] [Related]
15. Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3.
Beranič N; Gobec S; Rižner TL
Chem Biol Interact; 2011 May; 191(1-3):227-33. PubMed ID: 21182831
[TBL] [Abstract][Full Text] [Related]
16. Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily.
Steckelbroeck S; Oyesanmi B; Jin Y; Lee SH; Kloosterboer HJ; Penning TM
J Pharmacol Exp Ther; 2006 Mar; 316(3):1300-9. PubMed ID: 16339391
[TBL] [Abstract][Full Text] [Related]
17. Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.
Jin Y; Mesaros AC; Blair IA; Penning TM
Biochem J; 2011 Jul; 437(1):53-61. PubMed ID: 21521174
[TBL] [Abstract][Full Text] [Related]
18. Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid.
Steckelbroeck S; Jin Y; Oyesanmi B; Kloosterboer HJ; Penning TM
Mol Pharmacol; 2004 Dec; 66(6):1702-11. PubMed ID: 15383625
[TBL] [Abstract][Full Text] [Related]
19. Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids.
Couture JF; Legrand P; Cantin L; Luu-The V; Labrie F; Breton R
J Mol Biol; 2003 Aug; 331(3):593-604. PubMed ID: 12899831
[TBL] [Abstract][Full Text] [Related]
20. The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene.
Burczynski ME; Sridhar GR; Palackal NT; Penning TM
J Biol Chem; 2001 Jan; 276(4):2890-7. PubMed ID: 11060293
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
