BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

293 related articles for article (PubMed ID: 12604680)

  • 1. 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, reduces brain edema through the inhibition of enhanced blood-brain barrier permeability after transient focal ischemia.
    Sato T; Morishima Y; Shirasaki Y
    J Pharmacol Exp Ther; 2003 Mar; 304(3):1042-7. PubMed ID: 12604680
    [TBL] [Abstract][Full Text] [Related]  

  • 2. DY-9760e, a novel calmodulin antagonist, reduces infarction after permanent focal cerebral ischemia in rats.
    Sato T; Takamori H; Shirasaki Y
    Pharmacology; 2004 May; 71(1):38-45. PubMed ID: 15051921
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of dystrophin breakdown and endothelial nitric-oxide synthase uncoupling accounts for cytoprotection by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) in left ventricular hypertrophied Mice.
    Han F; Lu YM; Hasegawa H; Kanai H; Hachimura E; Shirasaki Y; Fukunaga K
    J Pharmacol Exp Ther; 2010 Feb; 332(2):421-8. PubMed ID: 19889795
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 3-[2-[4-(3-Chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydro-chloride 3.5 hydrate (DY-9760e) is neuroprotective in rat microsphere embolism: role of the cross-talk between calpain and caspase-3 through calpastatin.
    Han F; Shirasaki Y; Fukunaga K
    J Pharmacol Exp Ther; 2006 May; 317(2):529-36. PubMed ID: 16467455
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Microsphere embolism-induced endothelial nitric oxide synthase expression mediates disruption of the blood-brain barrier in rat brain.
    Han F; Shirasaki Y; Fukunaga K
    J Neurochem; 2006 Oct; 99(1):97-106. PubMed ID: 16987238
    [TBL] [Abstract][Full Text] [Related]  

  • 6. DY-9760e, a novel calmodulin inhibitor, exhibits cardioprotective effects in the ischemic heart.
    Fukunaga K; Han F; Shioda N; Moriguchi S; Kasahara J; Shirasaki Y
    Cardiovasc Drug Rev; 2006; 24(2):88-100. PubMed ID: 16961723
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The neuroprotective effect of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, in transient forebrain ischemia.
    Hashiguchi A; Kawano T; Yano S; Morioka M; Hamada J; Sato T; Shirasaki Y; Ushio Y; Fukunaga K
    Neuroscience; 2003; 121(2):379-86. PubMed ID: 14521996
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pharmacokinetics and disposition of DY-9760e, a novel calmodulin antagonist, in rats and monkeys.
    Tachibana S; Fujimaki Y; Tachibana M; Tanaka M; Kurata T; Okazaki O; Sudo K
    Arzneimittelforschung; 2005; 55(3):135-44. PubMed ID: 15819385
    [TBL] [Abstract][Full Text] [Related]  

  • 9. DY-9760e, a novel calmodulin antagonist, reduces brain damage induced by transient focal cerebral ischemia.
    Sato T; Morishima Y; Sugimura M; Uchida T; Shirasaki Y
    Eur J Pharmacol; 1999 Apr; 370(2):117-23. PubMed ID: 10323259
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Post-ischemic administration of DY-9760e, a novel calmodulin antagonist, reduced infarct volume in the permanent focal ischemia model of spontaneously hypertensive rat.
    Takagi K; Sato T; Shirasaki Y; Narita K; Tamura A; Sano K
    Neurol Res; 2001 Sep; 23(6):662-8. PubMed ID: 11547940
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The post-ischemic administration of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, prevents delayed neuronal death in gerbil hippocampus.
    Hashiguchi A; Yano S; Morioka M; Hamada J; Shirasaki Y; Kochi M; Fukunaga K
    J Pharmacol Sci; 2004 Sep; 96(1):65-72. PubMed ID: 15359085
    [TBL] [Abstract][Full Text] [Related]  

  • 12. DY-9760e, a calmodulin antagonist, reduces brain damage after permanent focal cerebral ischemia in cats.
    Sugimura M; Takamori H; Fukushi H; Kitano Y; Kanazawa Y; Shirasaki Y
    Biol Pharm Bull; 2005 Apr; 28(4):629-33. PubMed ID: 15802800
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cytoprotective effect of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) against ischemia/reperfusion-induced injury in rat heart involves inhibition of fodrin breakdown and protein tyrosine nitration.
    Hashimoto M; Takada Y; Takeuchi Y; Kasahara J; Hisa H; Shirasaki Y; Fukunaga K
    J Pharmacol Sci; 2005 Jun; 98(2):142-50. PubMed ID: 15937403
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effect of aminoguanidine on post-ischemic brain edema in transient model of focal cerebral ischemia.
    Vakili A; Hosseinzadeh F; Sadogh T
    Brain Res; 2007 Sep; 1170():97-102. PubMed ID: 17698046
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions.
    Tachibana S; Fujimaki Y; Yokoyama H; Okazaki O; Sudo K
    Drug Metab Dispos; 2005 Nov; 33(11):1628-36. PubMed ID: 16049129
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of neuronal nitric oxide synthase activity by 3-[2-[4-(3-chloro-2-methylphenyl)- 1-piperazinyl]ethyl]-5, 6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel neuroprotective agent, in vitro and in cultured neuroblastoma cells in situ.
    Fukunaga K; Ohmitsu M; Miyamoto E; Sato T; Sugimura M; Uchida T; Shirasaki Y
    Biochem Pharmacol; 2000 Sep; 60(5):693-9. PubMed ID: 10927028
    [TBL] [Abstract][Full Text] [Related]  

  • 17. DY-9760e, a novel calmodulin antagonist with cytoprotective action.
    Sugimura M; Sato T; Nakayama W; Morishima Y; Fukunaga K; Omitsu M; Miyamoto E; Shirasaki Y
    Eur J Pharmacol; 1997 Oct; 336(1):99-106. PubMed ID: 9384259
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Serum S-100b protein as a biomarker for the assessment of neuroprotectants.
    Shirasaki Y; Edo N; Sato T
    Brain Res; 2004 Sep; 1021(2):159-66. PubMed ID: 15342263
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Determination of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1- (4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, DY-9760e, in human plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection.
    Tachibana S; Fukano A; Sudo K; Tanaka M
    J Chromatogr B Biomed Sci Appl; 1999 Oct; 734(1):39-45. PubMed ID: 10574188
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibitory effect of sulfobutyl ether beta-cyclodextrin on DY-9760e-induced cellular damage: In vitro and in vivo studies.
    Nagase Y; Arima H; Wada K; Sugawara T; Satoh H; Hirayama F; Uekama K
    J Pharm Sci; 2003 Dec; 92(12):2466-74. PubMed ID: 14603492
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.