BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

117 related articles for article (PubMed ID: 12617932)

  • 1. Modification of the N-terminus of peptidomimetic protein tyrosine phosphatase 1B (PTP1B) inhibitors: identification of analogues with cellular activity.
    Larsen SD; Stevens FC; Lindberg TJ; Bodnar PM; O'Sullivan TJ; Schostarez HJ; Palazuk BJ; Bleasdale JE
    Bioorg Med Chem Lett; 2003 Mar; 13(5):971-5. PubMed ID: 12617932
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B.
    Larsen SD; Barf T; Liljebris C; May PD; Ogg D; O'Sullivan TJ; Palazuk BJ; Schostarez HJ; Stevens FC; Bleasdale JE
    J Med Chem; 2002 Jan; 45(3):598-622. PubMed ID: 11806712
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity.
    Liljebris C; Larsen SD; Ogg D; Palazuk BJ; Bleasdale JE
    J Med Chem; 2002 Apr; 45(9):1785-98. PubMed ID: 11960490
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
    Bleasdale JE; Ogg D; Palazuk BJ; Jacob CS; Swanson ML; Wang XY; Thompson DP; Conradi RA; Mathews WR; Laborde AL; Stuchly CW; Heijbel A; Bergdahl K; Bannow CA; Smith CW; Svensson C; Liljebris C; Schostarez HJ; May PD; Stevens FC; Larsen SD
    Biochemistry; 2001 May; 40(19):5642-54. PubMed ID: 11341829
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Protein tyrosine phosphatase 1B inhibition: opportunities and challenges.
    Liu G
    Curr Med Chem; 2003 Aug; 10(15):1407-21. PubMed ID: 12871138
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells.
    Ottanà R; Maccari R; Mortier J; Caselli A; Amuso S; Camici G; Rotondo A; Wolber G; Paoli P
    Eur J Med Chem; 2014 Jan; 71():112-27. PubMed ID: 24287560
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors.
    Klopfenstein SR; Evdokimov AG; Colson AO; Fairweather NT; Neuman JJ; Maier MB; Gray JL; Gerwe GS; Stake GE; Howard BW; Farmer JA; Pokross ME; Downs TR; Kasibhatla B; Peters KG
    Bioorg Med Chem Lett; 2006 Mar; 16(6):1574-8. PubMed ID: 16386905
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
    Groves MR; Yao ZJ; Roller PP; Burke TR; Barford D
    Biochemistry; 1998 Dec; 37(51):17773-83. PubMed ID: 9922143
    [TBL] [Abstract][Full Text] [Related]  

  • 9. New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells.
    Ottanà R; Maccari R; Amuso S; Wolber G; Schuster D; Herdlinger S; Manao G; Camici G; Paoli P
    Eur J Med Chem; 2012 Apr; 50():332-43. PubMed ID: 22381357
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake.
    Zhang W; Hong D; Zhou Y; Zhang Y; Shen Q; Li JY; Hu LH; Li J
    Biochim Biophys Acta; 2006 Oct; 1760(10):1505-12. PubMed ID: 16828971
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In silico structure-based design of a potent and selective small peptide inhibitor of protein tyrosine phosphatase 1B, a novel therapeutic target for obesity and type 2 diabetes mellitus: a computer modeling approach.
    Rao GS; Ramachandran MV; Bajaj JS
    J Biomol Struct Dyn; 2006 Feb; 23(4):377-84. PubMed ID: 16363874
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Potent inhibition of protein-tyrosine phosphatase-1B using the phosphotyrosyl mimetic fluoro-O-malonyl tyrosine (FOMT).
    Roller PP; Wu L; Zhang ZY; Burke TR
    Bioorg Med Chem Lett; 1998 Aug; 8(16):2149-50. PubMed ID: 9873503
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase.
    Maccari R; Ottanà R; Ciurleo R; Paoli P; Manao G; Camici G; Laggner C; Langer T
    ChemMedChem; 2009 Jun; 4(6):957-62. PubMed ID: 19288492
    [TBL] [Abstract][Full Text] [Related]  

  • 14. New azolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.
    Malamas MS; Sredy J; Gunawan I; Mihan B; Sawicki DR; Seestaller L; Sullivan D; Flam BR
    J Med Chem; 2000 Mar; 43(5):995-1010. PubMed ID: 10715163
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibitors of protein tyrosine phosphatase 1B (PTP1B).
    Taylor SD
    Curr Top Med Chem; 2003; 3(7):759-82. PubMed ID: 12678843
    [TBL] [Abstract][Full Text] [Related]  

  • 16. PTP1B as a drug target: recent developments in PTP1B inhibitor discovery.
    Zhang S; Zhang ZY
    Drug Discov Today; 2007 May; 12(9-10):373-81. PubMed ID: 17467573
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.
    Pei Z; Li X; Liu G; Abad-Zapatero C; Lubben T; Zhang T; Ballaron SJ; Hutchins CW; Trevillyan JM; Jirousek MR
    Bioorg Med Chem Lett; 2003 Oct; 13(19):3129-32. PubMed ID: 12951078
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and biological activity of a novel class of pyridazine analogues as non-competitive reversible inhibitors of protein tyrosine phosphatase 1B (PTP1B).
    Liljebris C; Martinsson J; Tedenborg L; Williams M; Barker E; Duffy JE; Nygren A; James S
    Bioorg Med Chem; 2002 Oct; 10(10):3197-212. PubMed ID: 12150865
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis of functionalized acetophenones as protein tyrosine phosphatase 1B inhibitors.
    Dixit M; Tripathi BK; Srivastava AK; Goel A
    Bioorg Med Chem Lett; 2005 Jul; 15(14):3394-7. PubMed ID: 15951172
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides.
    Burke TR; Ye B; Akamatsu M; Ford H; Yan X; Kole HK; Wolf G; Shoelson SE; Roller PP
    J Med Chem; 1996 Mar; 39(5):1021-7. PubMed ID: 8676336
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.