BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

312 related articles for article (PubMed ID: 12624180)

  • 1. Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.
    Yabe D; Komuro R; Liang G; Goldstein JL; Brown MS
    Proc Natl Acad Sci U S A; 2003 Mar; 100(6):3155-60. PubMed ID: 12624180
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.
    Engelking LJ; Kuriyama H; Hammer RE; Horton JD; Brown MS; Goldstein JL; Liang G
    J Clin Invest; 2004 Apr; 113(8):1168-75. PubMed ID: 15085196
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex.
    Yellaturu CR; Deng X; Park EA; Raghow R; Elam MB
    J Biol Chem; 2009 Nov; 284(46):31726-34. PubMed ID: 19759400
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.
    Yabe D; Brown MS; Goldstein JL
    Proc Natl Acad Sci U S A; 2002 Oct; 99(20):12753-8. PubMed ID: 12242332
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Differential regulation of sterol regulatory element-binding protein 1c transcriptional activity by insulin and liver X receptor during liver development.
    Bobard A; Hainault I; Ferré P; Foufelle F; Bossard P
    J Biol Chem; 2005 Jan; 280(1):199-206. PubMed ID: 15509573
    [TBL] [Abstract][Full Text] [Related]  

  • 6. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.
    Matsuda M; Korn BS; Hammer RE; Moon YA; Komuro R; Horton JD; Goldstein JL; Brown MS; Shimomura I
    Genes Dev; 2001 May; 15(10):1206-16. PubMed ID: 11358865
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
    Yang T; Espenshade PJ; Wright ME; Yabe D; Gong Y; Aebersold R; Goldstein JL; Brown MS
    Cell; 2002 Aug; 110(4):489-500. PubMed ID: 12202038
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.
    Lee PC; Sever N; Debose-Boyd RA
    J Biol Chem; 2005 Jul; 280(26):25242-9. PubMed ID: 15866869
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1.
    Lee JN; Ye J
    J Biol Chem; 2004 Oct; 279(43):45257-65. PubMed ID: 15304479
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice.
    Horton JD; Bashmakov Y; Shimomura I; Shimano H
    Proc Natl Acad Sci U S A; 1998 May; 95(11):5987-92. PubMed ID: 9600904
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.
    Yabe D; Xia ZP; Adams CM; Rawson RB
    Proc Natl Acad Sci U S A; 2002 Dec; 99(26):16672-7. PubMed ID: 12482938
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism.
    Shimano H
    Vitam Horm; 2002; 65():167-94. PubMed ID: 12481547
    [TBL] [Abstract][Full Text] [Related]  

  • 13. BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver.
    Tian J; Wu J; Chen X; Guo T; Chen ZJ; Goldstein JL; Brown MS
    Elife; 2018 Jun; 7():. PubMed ID: 29952285
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).
    Korn BS; Shimomura I; Bashmakov Y; Hammer RE; Horton JD; Goldstein JL; Brown MS
    J Clin Invest; 1998 Dec; 102(12):2050-60. PubMed ID: 9854040
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
    Shimano H; Horton JD; Shimomura I; Hammer RE; Brown MS; Goldstein JL
    J Clin Invest; 1997 Mar; 99(5):846-54. PubMed ID: 9062341
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid.
    Tong X; Christian P; Zhao M; Wang H; Moreau R; Su Q
    J Nutr Biochem; 2015 Sep; 26(9):921-8. PubMed ID: 26007286
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs.
    Dobrosotskaya IY; Goldstein JL; Brown MS; Rawson RB
    J Biol Chem; 2003 Sep; 278(37):35837-43. PubMed ID: 12842885
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue.
    Boden G; Salehi S; Cheung P; Homko C; Song W; Loveland-Jones C; Jayarajan S
    Obesity (Silver Spring); 2013 Jun; 21(6):1208-14. PubMed ID: 23913732
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Silibinin protects β cells from glucotoxicity through regulation of the Insig-1/SREBP-1c pathway.
    Chen K; Zhao L; He H; Wan X; Wang F; Mo Z
    Int J Mol Med; 2014 Oct; 34(4):1073-80. PubMed ID: 25109869
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.
    Sun LP; Li L; Goldstein JL; Brown MS
    J Biol Chem; 2005 Jul; 280(28):26483-90. PubMed ID: 15899885
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.