BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

300 related articles for article (PubMed ID: 12642383)

  • 1. Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents.
    Becker EM; Lovejoy DB; Greer JM; Watts R; Richardson DR
    Br J Pharmacol; 2003 Mar; 138(5):819-30. PubMed ID: 12642383
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development of novel aroylhydrazone ligands for iron chelation therapy: 2-pyridylcarboxaldehyde isonicotinoyl hydrazone analogs.
    Becker E; Richardson DR
    J Lab Clin Med; 1999 Nov; 134(5):510-21. PubMed ID: 10560945
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Potent antitumor activity of novel iron chelators derived from di-2-pyridylketone isonicotinoyl hydrazone involves fenton-derived free radical generation.
    Chaston TB; Watts RN; Yuan J; Richardson DR
    Clin Cancer Res; 2004 Nov; 10(21):7365-74. PubMed ID: 15534113
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Protection against hydrogen peroxide-mediated cytotoxicity in Friedreich's ataxia fibroblasts using novel iron chelators of the 2-pyridylcarboxaldehyde isonicotinoyl hydrazone class.
    Lim CK; Kalinowski DS; Richardson DR
    Mol Pharmacol; 2008 Jul; 74(1):225-35. PubMed ID: 18424550
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.
    Kalinowski DS; Sharpe PC; Bernhardt PV; Richardson DR
    J Med Chem; 2007 Nov; 50(24):6212-25. PubMed ID: 17963372
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone.
    Richardson DR; Milnes K
    Blood; 1997 Apr; 89(8):3025-38. PubMed ID: 9108424
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Unprecedented oxidation of a biologically active aroylhydrazone chelator catalysed by iron(III): serendipitous identification of diacylhydrazine ligands with high iron chelation efficacy.
    Bernhardt PV; Chin P; Richardson DR
    J Biol Inorg Chem; 2001 Oct; 6(8):801-9. PubMed ID: 11713687
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Potent antimycobacterial activity of the pyridoxal isonicotinoyl hydrazone analog 2-pyridylcarboxaldehyde isonicotinoyl hydrazone: a lipophilic transport vehicle for isonicotinic acid hydrazide.
    Ellis S; Kalinowski DS; Leotta L; Huang ML; Jelfs P; Sintchenko V; Richardson DR; Triccas JA
    Mol Pharmacol; 2014 Feb; 85(2):269-78. PubMed ID: 24243647
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Complexes of cytotoxic chelators from the dipyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues.
    Bernhardt PV; Mattsson J; Richardson DR
    Inorg Chem; 2006 Jan; 45(2):752-60. PubMed ID: 16411711
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311.
    Chaston TB; Lovejoy DB; Watts RN; Richardson DR
    Clin Cancer Res; 2003 Jan; 9(1):402-14. PubMed ID: 12538494
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: novel iron chelators with selective antiproliferative action.
    Macková E; Hrušková K; Bendová P; Vávrová A; Jansová H; Hašková P; Kovaříková P; Vávrová K; Simůnek T
    Chem Biol Interact; 2012 May; 197(2-3):69-79. PubMed ID: 22521999
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Future of toxicology--iron chelators and differing modes of action and toxicity: the changing face of iron chelation therapy.
    Kalinowski DS; Richardson DR
    Chem Res Toxicol; 2007 May; 20(5):715-20. PubMed ID: 17402750
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III: the effect of the ligands on molecular targets involved in proliferation.
    Darnell G; Richardson DR
    Blood; 1999 Jul; 94(2):781-92. PubMed ID: 10397746
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series.
    Kalinowski DS; Sharpe PC; Bernhardt PV; Richardson DR
    J Med Chem; 2008 Jan; 51(2):331-44. PubMed ID: 18159922
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.
    Potůčková E; Hrušková K; Bureš J; Kovaříková P; Špirková IA; Pravdíková K; Kolbabová L; Hergeselová T; Hašková P; Jansová H; Macháček M; Jirkovská A; Richardson V; Lane DJ; Kalinowski DS; Richardson DR; Vávrová K; Šimůnek T
    PLoS One; 2014; 9(11):e112059. PubMed ID: 25393531
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Interactions of the pyridine-2-carboxaldehyde isonicotinoyl hydrazone class of chelators with iron and DNA: implications for toxicity in the treatment of iron overload disease.
    Chaston TB; Richardson DR
    J Biol Inorg Chem; 2003 Apr; 8(4):427-38. PubMed ID: 12761664
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cytotoxic iron chelators: characterization of the structure, solution chemistry and redox activity of ligands and iron complexes of the di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues.
    Bernhardt PV; Caldwell LM; Chaston TB; Chin P; Richardson DR
    J Biol Inorg Chem; 2003 Nov; 8(8):866-80. PubMed ID: 14564555
    [TBL] [Abstract][Full Text] [Related]  

  • 18. PCTH: a novel orally active chelator for the treatment of iron overload disease.
    Lovejoy DB; Kalinowski D; Bernhardt PV; Richardson DR
    Hemoglobin; 2006; 30(1):93-104. PubMed ID: 16540421
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
    Kalinowski DS; Yu Y; Sharpe PC; Islam M; Liao YT; Lovejoy DB; Kumar N; Bernhardt PV; Richardson DR
    J Med Chem; 2007 Jul; 50(15):3716-29. PubMed ID: 17602603
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligands.
    Bernhardt PV; Wilson GJ; Sharpe PC; Kalinowski DS; Richardson DR
    J Biol Inorg Chem; 2008 Jan; 13(1):107-19. PubMed ID: 17899222
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.