BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

100 related articles for article (PubMed ID: 12642467)

  • 1. Characterization of substrate binding to cytochrome P450 1A1 using molecular modeling and kinetic analyses: case of residue 382.
    Liu J; Ericksen SS; Besspiata D; Fisher CW; Szklarz GD
    Drug Metab Dispos; 2003 Apr; 31(4):412-20. PubMed ID: 12642467
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The effect of reciprocal active site mutations in human cytochromes P450 1A1 and 1A2 on alkoxyresorufin metabolism.
    Liu J; Ericksen SS; Sivaneri M; Besspiata D; Fisher CW; Szklarz GD
    Arch Biochem Biophys; 2004 Apr; 424(1):33-43. PubMed ID: 15019834
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Application of molecular modeling for prediction of substrate specificity in cytochrome P450 1A2 mutants.
    Tu Y; Deshmukh R; Sivaneri M; Szklarz GD
    Drug Metab Dispos; 2008 Nov; 36(11):2371-80. PubMed ID: 18703643
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular modeling of cytochrome P450 1A1: enzyme-substrate interactions and substrate binding affinities.
    Szklarz GD; Paulsen MD
    J Biomol Struct Dyn; 2002 Oct; 20(2):155-62. PubMed ID: 12354067
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Probing the active site of cytochrome P450 2B1: metabolism of 7-alkoxycoumarins by the wild type and five site-directed mutants.
    Kobayashi Y; Fang X; Szklarz GD; Halpert JR
    Biochemistry; 1998 May; 37(19):6679-88. PubMed ID: 9578551
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies.
    He YQ; He YA; Halpert JR
    Chem Res Toxicol; 1995 Jun; 8(4):574-9. PubMed ID: 7548737
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
    Liu J; He YA; Halpert JR
    Arch Biochem Biophys; 1996 Mar; 327(1):167-73. PubMed ID: 8615687
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of the Ala62Pro polymorphic variant of human cytochrome P450 1A1 using recombinant protein expression.
    Lee SH; Kang S; Dong MS; Park JD; Park J; Rhee S; Ryu DY
    Toxicol Appl Pharmacol; 2015 Jun; 285(3):159-69. PubMed ID: 25902338
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Construction of a human cytochrome P450 1A1: rat NADPH-cytochrome P450 reductase fusion protein cDNA and expression in Escherichia coli, purification, and catalytic properties of the enzyme in bacterial cells and after purification.
    Chun YJ; Shimada T; Guengerich FP
    Arch Biochem Biophys; 1996 Jun; 330(1):48-58. PubMed ID: 8651703
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate.
    Chang TK; Waxman DJ
    Methods Mol Biol; 2006; 320():85-90. PubMed ID: 16719376
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular Cloning, Tissue Distribution, and Functional Characterization of Marmoset Cytochrome P450 1A1, 1A2, and 1B1.
    Uehara S; Uno Y; Inoue T; Sasaki E; Yamazaki H
    Drug Metab Dispos; 2016 Jan; 44(1):8-15. PubMed ID: 26502772
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
    Szklarz GD; He YQ; Kedzie KM; Halpert JR; Burnett VL
    Arch Biochem Biophys; 1996 Mar; 327(2):308-18. PubMed ID: 8619620
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
    He YQ; Szklarz GD; Halpert JR
    Arch Biochem Biophys; 1996 Nov; 335(1):152-60. PubMed ID: 8914846
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Comparative homology modeling of human cytochrome P4501A1 (CYP1A1) and confirmation of residues involved in 7-ethoxyresorufin O-deethylation by site-directed mutagenesis and enzyme kinetic analysis.
    Lewis BC; Mackenzie PI; Miners JO
    Arch Biochem Biophys; 2007 Dec; 468(1):58-69. PubMed ID: 17959138
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Molecular recognition in (+)-alpha-pinene oxidation by cytochrome P450cam.
    Bell SG; Chen X; Sowden RJ; Xu F; Williams JN; Wong LL; Rao Z
    J Am Chem Soc; 2003 Jan; 125(3):705-14. PubMed ID: 12526670
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6.
    Hayhurst GP; Harlow J; Chowdry J; Gross E; Hilton E; Lennard MS; Tucker GT; Ellis SW
    Biochem J; 2001 Apr; 355(Pt 2):373-9. PubMed ID: 11284724
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling.
    Spatzenegger M; Liu H; Wang Q; Debarber A; Koop DR; Halpert JR
    J Pharmacol Exp Ther; 2003 Jan; 304(1):477-87. PubMed ID: 12490624
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1A1: a CO flash photolysis study.
    Koley AP; Buters JT; Robinson RC; Markowitz A; Friedman FK
    Arch Biochem Biophys; 1996 Dec; 336(2):261-7. PubMed ID: 8954573
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mechanism-based inactivation of hepatic ethoxyresorufin O-dealkylation activity by naturally occurring coumarins.
    Cai Y; Baer-Dubowska W; Ashwood-Smith MJ; Ceska O; Tachibana S; DiGiovanni J
    Chem Res Toxicol; 1996 Jun; 9(4):729-36. PubMed ID: 8831817
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Enhancement of 7-methoxyresorufin O-demethylation activity of human cytochrome P450 1A2 by molecular breeding.
    Kim D; Guengerich FP
    Arch Biochem Biophys; 2004 Dec; 432(1):102-8. PubMed ID: 15519301
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.