BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

120 related articles for article (PubMed ID: 12643929)

  • 1. Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase.
    Penning TD; Chandrakumar NS; Desai BN; Djuric SW; Gasiecki AF; Malecha JW; Miyashiro JM; Russell MA; Askonas LJ; Gierse JK; Harding EI; Highkin MK; Kachur JF; Kim SH; Villani-Price D; Pyla EY; Ghoreishi-Haack NS; Smith WG
    Bioorg Med Chem Lett; 2003 Mar; 13(6):1137-9. PubMed ID: 12643929
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase.
    Penning TD; Chandrakumar NS; Desai BN; Djuric SW; Gasiecki AF; Liang CD; Miyashiro JM; Russell MA; Askonas LJ; Gierse JK; Harding EI; Highkin MK; Kachur JF; Kim SH; Villani-Price D; Pyla EY; Ghoreishi-Haack NS; Smith WG
    Bioorg Med Chem Lett; 2002 Dec; 12(23):3383-6. PubMed ID: 12419366
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.
    Penning TD; Chandrakumar NS; Chen BB; Chen HY; Desai BN; Djuric SW; Docter SH; Gasiecki AF; Haack RA; Miyashiro JM; Russell MA; Yu SS; Corley DG; Durley RC; Kilpatrick BF; Parnas BL; Askonas LJ; Gierse JK; Harding EI; Highkin MK; Kachur JF; Kim SH; Krivi GG; Villani-Price D; Pyla EY; Smith WG
    J Med Chem; 2000 Feb; 43(4):721-35. PubMed ID: 10691697
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid.
    Penning TD; Russell MA; Chen BB; Chen HY; Liang CD; Mahoney MW; Malecha JW; Miyashiro JM; Yu SS; Askonas LJ; Gierse JK; Harding EI; Highkin MK; Kachur JF; Kim SH; Villani-Price D; Pyla EY; Ghoreishi-Haack NS; Smith WG
    J Med Chem; 2002 Aug; 45(16):3482-90. PubMed ID: 12139459
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds.
    Sandanayaka V; Mamat B; Bhagat N; Bedell L; Halldorsdottir G; Sigthorsdottir H; Andrésson T; Kiselyov A; Gurney M; Singh J
    Bioorg Med Chem Lett; 2010 May; 20(9):2851-4. PubMed ID: 20371179
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors.
    Khim SK; Bauman J; Evans J; Freeman B; King B; Kirkland T; Kochanny M; Lentz D; Liang A; Mendoza L; Phillips G; Tseng JL; Wei RG; Ye H; Yu L; Parkinson J; Guilford WJ
    Bioorg Med Chem Lett; 2008 Jul; 18(14):3895-8. PubMed ID: 18590959
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase II: in vivo studies.
    Kachur JF; Askonas LJ; Villani-Price D; Ghoreishi-Haack N; Won-Kim S; Liang CD; Russell MA; Smith WG
    J Pharmacol Exp Ther; 2002 Feb; 300(2):583-7. PubMed ID: 11805220
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Thermodynamic properties of leukotriene A
    Wittmann SK; Kalinowsky L; Kramer JS; Bloecher R; Knapp S; Steinhilber D; Pogoryelov D; Proschak E; Heering J
    Bioorg Med Chem; 2016 Nov; 24(21):5243-5248. PubMed ID: 27651294
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development of selective tight-binding inhibitors of leukotriene A4 hydrolase.
    Yuan W; Munoz B; Wong CH; Haeggström JZ; Wetterholm A; Samuelsson B
    J Med Chem; 1993 Jan; 36(2):211-20. PubMed ID: 8423594
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase.
    Jones PD; Tsai HJ; Do ZN; Morisseau C; Hammock BD
    Bioorg Med Chem Lett; 2006 Oct; 16(19):5212-6. PubMed ID: 16870439
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase I: in vitro studies.
    Askonas LJ; Kachur JF; Villani-Price D; Liang CD; Russell MA; Smith WG
    J Pharmacol Exp Ther; 2002 Feb; 300(2):577-82. PubMed ID: 11805219
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
    Grice CA; Tays KL; Savall BM; Wei J; Butler CR; Axe FU; Bembenek SD; Fourie AM; Dunford PJ; Lundeen K; Coles F; Xue X; Riley JP; Williams KN; Karlsson L; Edwards JP
    J Med Chem; 2008 Jul; 51(14):4150-69. PubMed ID: 18588282
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase.
    Hogg JH; Ollmann IR; Haeggström JZ; Wetterholm A; Samuelsson B; Wong CH
    Bioorg Med Chem; 1995 Oct; 3(10):1405-15. PubMed ID: 8564408
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.
    Sandanayaka V; Mamat B; Mishra RK; Winger J; Krohn M; Zhou LM; Keyvan M; Enache L; Sullins D; Onua E; Zhang J; Halldorsdottir G; Sigthorsdottir H; Thorlaksdottir A; Sigthorsson G; Thorsteinnsdottir M; Davies DR; Stewart LJ; Zembower DE; Andresson T; Kiselyov AS; Singh J; Gurney ME
    J Med Chem; 2010 Jan; 53(2):573-85. PubMed ID: 19950900
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase.
    Dhar TG; Liu C; Pitts WJ; Guo J; Watterson SH; Gu H; Fleener CA; Rouleau K; Sherbina NZ; Barrish JC; Hollenbaugh D; Iwanowicz EJ
    Bioorg Med Chem Lett; 2002 Nov; 12(21):3125-8. PubMed ID: 12372516
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Potent urea and carbamate inhibitors of soluble epoxide hydrolases.
    Morisseau C; Goodrow MH; Dowdy D; Zheng J; Greene JF; Sanborn JR; Hammock BD
    Proc Natl Acad Sci U S A; 1999 Aug; 96(16):8849-54. PubMed ID: 10430859
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Azabenzthiazole inhibitors of leukotriene A₄ hydrolase.
    Tanis VM; Bacani GM; Blevitt JM; Chrovian CC; Crawford S; De Leon A; Fourie AM; Gomez L; Grice CA; Herman K; Kearney AM; Landry-Bayle AM; Lee-Dutra A; Nelson J; Riley JP; Santillán A; Wiener JJ; Xue X; Young AL
    Bioorg Med Chem Lett; 2012 Dec; 22(24):7504-11. PubMed ID: 23127888
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton.
    Rao NL; Dunford PJ; Xue X; Jiang X; Lundeen KA; Coles F; Riley JP; Williams KN; Grice CA; Edwards JP; Karlsson L; Fourie AM
    J Pharmacol Exp Ther; 2007 Jun; 321(3):1154-60. PubMed ID: 17371808
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase.
    Ye B; Bauman J; Chen M; Davey D; Khim SK; King B; Kirkland T; Kochanny M; Liang A; Lentz D; May K; Mendoza L; Phillips G; Selchau V; Schlyer S; Tseng JL; Wei RG; Ye H; Parkinson J; Guilford WJ
    Bioorg Med Chem Lett; 2008 Jul; 18(14):3891-4. PubMed ID: 18586492
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis, docking, cytotoxicity, and LTA
    El-Naggar MH; Mira A; Abdel Bar FM; Shimizu K; Amer MM; Badria FA
    Bioorg Med Chem; 2017 Feb; 25(3):1277-1285. PubMed ID: 28065501
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.