BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1091 related articles for article (PubMed ID: 12649187)

  • 1. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.
    Blaskovich MA; Sun J; Cantor A; Turkson J; Jove R; Sebti SM
    Cancer Res; 2003 Mar; 63(6):1270-9. PubMed ID: 12649187
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.
    Sun J; Blaskovich MA; Jove R; Livingston SK; Coppola D; Sebti SM
    Oncogene; 2005 May; 24(20):3236-45. PubMed ID: 15735720
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.
    Yang L; Dan HC; Sun M; Liu Q; Sun XM; Feldman RI; Hamilton AD; Polokoff M; Nicosia SV; Herlyn M; Sebti SM; Cheng JQ
    Cancer Res; 2004 Jul; 64(13):4394-9. PubMed ID: 15231645
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells.
    Proietti C; Salatino M; Rosemblit C; Carnevale R; Pecci A; Kornblihtt AR; Molinolo AA; Frahm I; Charreau EH; Schillaci R; Elizalde PV
    Mol Cell Biol; 2005 Jun; 25(12):4826-40. PubMed ID: 15923602
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Role of the Janus kinase (JAK)/signal transducters and activators of transcription (STAT) cascade in advanced glycation end-product-induced cellular mitogenesis in NRK-49F cells.
    Huang JS; Guh JY; Hung WC; Yang ML; Lai YH; Chen HC; Chuang LY
    Biochem J; 1999 Aug; 342 ( Pt 1)(Pt 1):231-8. PubMed ID: 10432321
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells.
    Burke WM; Jin X; Lin HJ; Huang M; Liu R; Reynolds RK; Lin J
    Oncogene; 2001 Nov; 20(55):7925-34. PubMed ID: 11753675
    [TBL] [Abstract][Full Text] [Related]  

  • 7. JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells.
    Shi X; Franko B; Frantz C; Amin HM; Lai R
    Br J Haematol; 2006 Oct; 135(1):26-32. PubMed ID: 16939498
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK-STAT activation.
    Iwamoto T; Senga T; Naito Y; Matsuda S; Miyake Y; Yoshimura A; Hamaguchi M
    Oncogene; 2000 Sep; 19(41):4795-801. PubMed ID: 11032030
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cross-talk between interleukin 1beta (IL-1beta) and IL-6 signalling pathways: IL-1beta selectively inhibits IL-6-activated signal transducer and activator of transcription factor 1 (STAT1) by a proteasome-dependent mechanism.
    Shen X; Tian Z; Holtzman MJ; Gao B
    Biochem J; 2000 Dec; 352 Pt 3(Pt 3):913-9. PubMed ID: 11104703
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells.
    Garcia R; Bowman TL; Niu G; Yu H; Minton S; Muro-Cacho CA; Cox CE; Falcone R; Fairclough R; Parsons S; Laudano A; Gazit A; Levitzki A; Kraker A; Jove R
    Oncogene; 2001 May; 20(20):2499-513. PubMed ID: 11420660
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, EKB-569, in tumor cells and normal human keratinocytes.
    Nunes M; Shi C; Greenberger LM
    Mol Cancer Ther; 2004 Jan; 3(1):21-7. PubMed ID: 14749472
    [TBL] [Abstract][Full Text] [Related]  

  • 12. SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation.
    Duan Z; Bradner JE; Greenberg E; Levine R; Foster R; Mahoney J; Seiden MV
    Clin Cancer Res; 2006 Nov; 12(22):6844-52. PubMed ID: 17121906
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways.
    Xu Q; Briggs J; Park S; Niu G; Kortylewski M; Zhang S; Gritsko T; Turkson J; Kay H; Semenza GL; Cheng JQ; Jove R; Yu H
    Oncogene; 2005 Aug; 24(36):5552-60. PubMed ID: 16007214
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway.
    Dong Y; Lu B; Zhang X; Zhang J; Lai L; Li D; Wu Y; Song Y; Luo J; Pang X; Yi Z; Liu M
    Carcinogenesis; 2010 Dec; 31(12):2097-104. PubMed ID: 20732905
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway.
    Nefedova Y; Nagaraj S; Rosenbauer A; Muro-Cacho C; Sebti SM; Gabrilovich DI
    Cancer Res; 2005 Oct; 65(20):9525-35. PubMed ID: 16230418
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity.
    Zhang Y; Turkson J; Carter-Su C; Smithgall T; Levitzki A; Kraker A; Krolewski JJ; Medveczky P; Jove R
    J Biol Chem; 2000 Aug; 275(32):24935-44. PubMed ID: 10823829
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Constitutive activation of Jak-2 and Tyk-2 in a v-Src-transformed human gallbladder adenocarcinoma cell line.
    Murakami Y; Nakano S; Niho Y; Hamasaki N; Izuhara K
    J Cell Physiol; 1998 May; 175(2):220-8. PubMed ID: 9525481
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B leukemic cells.
    Ishdorj G; Johnston JB; Gibson SB
    BMC Cancer; 2011 Jun; 11():268. PubMed ID: 21702955
    [TBL] [Abstract][Full Text] [Related]  

  • 19. JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells.
    De Vos J; Jourdan M; Tarte K; Jasmin C; Klein B
    Br J Haematol; 2000 Jun; 109(4):823-8. PubMed ID: 10929036
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Resistance to small molecule inhibitors of epidermal growth factor receptor in malignant gliomas.
    Li B; Chang CM; Yuan M; McKenna WG; Shu HK
    Cancer Res; 2003 Nov; 63(21):7443-50. PubMed ID: 14612544
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 55.