BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

103 related articles for article (PubMed ID: 12657277)

  • 1. Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents.
    Magnin DR; Biller SA; Wetterau J; Robl JA; Dickson JK; Taunk P; Harrity TW; Lawrence RM; Sun CQ; Wang T; Logan J; Fryszman O; Connolly F; Jolibois K; Kunselman L
    Bioorg Med Chem Lett; 2003 Apr; 13(7):1337-40. PubMed ID: 12657277
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.
    Robl JA; Sulsky R; Sun CQ; Simpkins LM; Wang T; Dickson JK; Chen Y; Magnin DR; Taunk P; Slusarchyk WA; Biller SA; Lan SJ; Connolly F; Kunselman LK; Sabrah T; Jamil H; Gordon D; Harrity TW; Wetterau JR
    J Med Chem; 2001 Mar; 44(6):851-6. PubMed ID: 11300866
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.
    Wetterau JR; Gregg RE; Harrity TW; Arbeeny C; Cap M; Connolly F; Chu CH; George RJ; Gordon DA; Jamil H; Jolibois KG; Kunselman LK; Lan SJ; Maccagnan TJ; Ricci B; Yan M; Young D; Chen Y; Fryszman OM; Logan JV; Musial CL; Poss MA; Robl JA; Simpkins LM; Slusarchyk WA; Sulsky R; Taunk P; Magnin DR; Tino JA; Lawrence RM; Dickson JK; Biller SA
    Science; 1998 Oct; 282(5389):751-4. PubMed ID: 9784135
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition of microsomal triglyceride transfer protein improves insulin sensitivity and reduces atherogenic risk in Zucker fatty rats.
    Dhote V; Joharapurkar A; Kshirsagar S; Dhanesha N; Patel V; Patel A; Raval S; Jain M
    Clin Exp Pharmacol Physiol; 2011 May; 38(5):338-44. PubMed ID: 21401695
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives.
    O'Brien PM; Sliskovic DR; Picard JA; Lee HT; Purchase CF; Roth BD; White AD; Anderson M; Mueller SB; Bocan T; Bousley R; Hamelehle KL; Homan R; Lee P; Krause BR; Reindel JF; Stanfield RL; Turluck D
    J Med Chem; 1996 Jun; 39(12):2354-66. PubMed ID: 8691430
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and biological evaluation of quinuclidine derivatives incorporating phenothiazine moieties as squalene synthase inhibitors.
    Ishihara T; Kakuta H; Moritani H; Ugawa T; Yanagisawa I
    Chem Pharm Bull (Tokyo); 2004 Oct; 52(10):1204-9. PubMed ID: 15467236
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Diaminoindanes as microsomal triglyceride transfer protein inhibitors.
    Ksander GM; deJesus R; Yuan A; Fink C; Moskal M; Carlson E; Kukkola P; Bilci N; Wallace E; Neubert A; Feldman D; Mogelesky T; Poirier K; Jeune M; Steele R; Wasvery J; Stephan Z; Cahill E; Webb R; Navarrete A; Lee W; Gibson J; Alexander N; Sharif H; Hospattankar A
    J Med Chem; 2001 Dec; 44(26):4677-87. PubMed ID: 11741485
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Microsomal triglyceride transfer protein (MTP) inhibitors: discovery of clinically active inhibitors using high-throughput screening and parallel synthesis paradigms.
    Chang G; Ruggeri RB; Harwood HJ
    Curr Opin Drug Discov Devel; 2002 Jul; 5(4):562-70. PubMed ID: 12197314
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis of iodinated biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.
    Burnett DA; Caplen MA; Domalski MS; Browne ME; Davis HR; Clader JW
    Bioorg Med Chem Lett; 2002 Feb; 12(3):311-4. PubMed ID: 11814785
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pharmacological characterization of diethyl-2-({3-dimethylcarbamoyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an intestine-specific inhibitor of microsomal triglyceride transfer protein.
    Mera Y; Odani N; Kawai T; Hata T; Suzuki M; Hagiwara A; Katsushima T; Kakutani M
    J Pharmacol Exp Ther; 2011 Feb; 336(2):321-7. PubMed ID: 20974698
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Lomitapide, a microsomal triglyceride transfer protein inhibitor for the treatment of hypercholesterolemia.
    Rizzo M
    IDrugs; 2010 Feb; 13(2):103-11. PubMed ID: 20127562
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.
    Walker KA; Kertesz DJ; Rotstein DM; Swinney DC; Berry PW; So OY; Webb AS; Watson DM; Mak AY; Burton PM
    J Med Chem; 1993 Jul; 36(15):2235-7. PubMed ID: 8340925
    [No Abstract]   [Full Text] [Related]  

  • 13. Substituted 2-azaspiro[5.3]nonan-1-ones as potent cholesterol absorption inhibitors: defining a binding conformation for SCH 48461.
    Dugar S; Clader JW; Chan TM; Davis H
    J Med Chem; 1995 Dec; 38(25):4875-7. PubMed ID: 8523398
    [No Abstract]   [Full Text] [Related]  

  • 14. A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: biochemical, pharmacodynamic, pharmacokinetic, and safety profile.
    Kim E; Campbell S; Schueller O; Wong E; Cole B; Kuo J; Ellis J; Ferkany J; Sweetnam P
    J Pharmacol Exp Ther; 2011 Jun; 337(3):775-85. PubMed ID: 21406547
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery, synthesis and evaluation of novel cholesterol absorption inhibitors.
    Zhu X; Ji J; Huang D; Zhu Y; Tang C; Yang X; Qian H; Huang W
    Chem Biol Drug Des; 2012 Sep; 80(3):426-33. PubMed ID: 22642541
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.
    Sulsky R; Robl JA; Biller SA; Harrity TW; Wetterau J; Connolly F; Jolibois K; Kunselman L
    Bioorg Med Chem Lett; 2004 Oct; 14(20):5067-70. PubMed ID: 15380200
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Microsomal transfer protein inhibitors, new approach for treatment of familial hypercholesterolemia, review of the literature, original findings, and clinical significance.
    Kolovou G; Vasiliadis I; Gontoras N; Kolovou V; Hatzigeorgiou G
    Cardiovasc Ther; 2015 Apr; 33(2):71-8. PubMed ID: 25604780
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Lipid-lowering activity of atorvastatin and lovastatin in rodent species: triglyceride-lowering in rats correlates with efficacy in LDL animal models.
    Krause BR; Newton RS
    Atherosclerosis; 1995 Oct; 117(2):237-44. PubMed ID: 8801869
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular cloning, expression, and hormonal regulation of the chicken microsomal triglyceride transfer protein.
    Ivessa NE; Rehberg E; Kienzle B; Seif F; Hermann R; Hermann M; Schneider WJ; Gordon DA
    Gene; 2013 Jul; 523(1):1-9. PubMed ID: 23542778
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide.
    Robinson RP; Bartlett JA; Bertinato P; Bessire AJ; Cosgrove J; Foley PM; Manion TB; Minich ML; Ramos B; Reese MR; Schmahai TJ; Swick AG; Tess DA; Vaz A; Wolford A
    Bioorg Med Chem Lett; 2011 Jul; 21(14):4150-4. PubMed ID: 21684740
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.