BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

293 related articles for article (PubMed ID: 12657718)

  • 1. The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.
    Welsh SJ; Williams RR; Birmingham A; Newman DJ; Kirkpatrick DL; Powis G
    Mol Cancer Ther; 2003 Mar; 2(3):235-43. PubMed ID: 12657718
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis.
    Welsh SJ; Bellamy WT; Briehl MM; Powis G
    Cancer Res; 2002 Sep; 62(17):5089-95. PubMed ID: 12208766
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation.
    Jones DT; Pugh CW; Wigfield S; Stevens MF; Harris AL
    Clin Cancer Res; 2006 Sep; 12(18):5384-94. PubMed ID: 17000671
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Antitumor agent PX-12 inhibits HIF-1α protein levels through an Nrf2/PMF-1-mediated increase in spermidine/spermine acetyl transferase.
    Kim YH; Coon A; Baker AF; Powis G
    Cancer Chemother Pharmacol; 2011 Aug; 68(2):405-13. PubMed ID: 21069338
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging.
    Jordan BF; Runquist M; Raghunand N; Gillies RJ; Tate WR; Powis G; Baker AF
    Clin Cancer Res; 2005 Jan; 11(2 Pt 1):529-36. PubMed ID: 15701837
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.
    Welsh S; Williams R; Kirkpatrick L; Paine-Murrieta G; Powis G
    Mol Cancer Ther; 2004 Mar; 3(3):233-44. PubMed ID: 15026543
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Antisense-thioredoxin inhibits angiogenesis via pVHL-mediated hypoxia-inducible factor-1alpha degradation.
    Kim WJ; Cho H; Lee SW; Kim YJ; Kim KW
    Int J Oncol; 2005 Apr; 26(4):1049-52. PubMed ID: 15754001
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hypoxia inducible factor-1α inhibition produced anti-allodynia effect and suppressed inflammatory cytokine production in early stage of mouse complex regional pain syndrome model.
    Hsiao HT; Lin YC; Wang JC; Tsai YC; Liu YC
    Clin Exp Pharmacol Physiol; 2016 Mar; 43(3):355-9. PubMed ID: 26711019
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
    Blancher C; Moore JW; Robertson N; Harris AL
    Cancer Res; 2001 Oct; 61(19):7349-55. PubMed ID: 11585776
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma.
    Baker AF; Dragovich T; Tate WR; Ramanathan RK; Roe D; Hsu CH; Kirkpatrick DL; Powis G
    J Lab Clin Med; 2006 Feb; 147(2):83-90. PubMed ID: 16459166
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding.
    Jones DT; Harris AL
    Mol Cancer Ther; 2006 Sep; 5(9):2193-202. PubMed ID: 16985052
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts.
    Kurebayashi J; Otsuki T; Kurosumi M; Soga S; Akinaga S; Sonoo H
    Jpn J Cancer Res; 2001 Dec; 92(12):1342-51. PubMed ID: 11749701
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway.
    Carroll VA; Ashcroft M
    Cancer Res; 2006 Jun; 66(12):6264-70. PubMed ID: 16778202
    [TBL] [Abstract][Full Text] [Related]  

  • 14. trans-3,4,5'-Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells.
    Cao Z; Fang J; Xia C; Shi X; Jiang BH
    Clin Cancer Res; 2004 Aug; 10(15):5253-63. PubMed ID: 15297429
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation.
    Stoeltzing O; McCarty MF; Wey JS; Fan F; Liu W; Belcheva A; Bucana CD; Semenza GL; Ellis LM
    J Natl Cancer Inst; 2004 Jun; 96(12):946-56. PubMed ID: 15199114
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Accumulation of HIF-1alpha under the influence of nitric oxide.
    Sandau KB; Fandrey J; Brüne B
    Blood; 2001 Feb; 97(4):1009-15. PubMed ID: 11159530
    [TBL] [Abstract][Full Text] [Related]  

  • 17. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression.
    Laughner E; Taghavi P; Chiles K; Mahon PC; Semenza GL
    Mol Cell Biol; 2001 Jun; 21(12):3995-4004. PubMed ID: 11359907
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hypoxia-induced expression of HIF-1alpha and its target genes in umbilical venous endothelial cells of Tibetans and immigrant Han.
    Gao W; Gao Y; Zhang G; Song L; Sun B; Shi J
    Comp Biochem Physiol C Toxicol Pharmacol; 2005 May; 141(1):93-100. PubMed ID: 15970466
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors.
    Yamakawa M; Liu LX; Date T; Belanger AJ; Vincent KA; Akita GY; Kuriyama T; Cheng SH; Gregory RJ; Jiang C
    Circ Res; 2003 Oct; 93(7):664-73. PubMed ID: 12958144
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Hypoxic induction of HIF-1alpha and VEGF expression in head and neck squamous cell carcinoma lines is mediated by stress activated protein kinases.
    Shemirani B; Crowe DL
    Oral Oncol; 2002 Apr; 38(3):251-7. PubMed ID: 11978547
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.