These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

232 related articles for article (PubMed ID: 12663444)

  • 1. Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells.
    Persons DA; Allay ER; Sawai N; Hargrove PW; Brent TP; Hanawa H; Nienhuis AW; Sorrentino BP
    Blood; 2003 Jul; 102(2):506-13. PubMed ID: 12663444
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene.
    Zhao H; Pestina TI; Nasimuzzaman M; Mehta P; Hargrove PW; Persons DA
    Blood; 2009 Jun; 113(23):5747-56. PubMed ID: 19365082
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells.
    Ragg S; Xu-Welliver M; Bailey J; D'Souza M; Cooper R; Chandra S; Seshadri R; Pegg AE; Williams DA
    Cancer Res; 2000 Sep; 60(18):5187-95. PubMed ID: 11016647
    [TBL] [Abstract][Full Text] [Related]  

  • 4. In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.
    Larochelle A; Choi U; Shou Y; Naumann N; Loktionova NA; Clevenger JR; Krouse A; Metzger M; Donahue RE; Kang E; Stewart C; Persons D; Malech HL; Dunbar CE; Sorrentino BP
    J Clin Invest; 2009 Jul; 119(7):1952-63. PubMed ID: 19509470
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Davis BM; Reese JS; Koç ON; Lee K; Schupp JE; Gerson SL
    Cancer Res; 1997 Nov; 57(22):5093-9. PubMed ID: 9371508
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker.
    Choi U; DeRavin SS; Yamashita K; Whiting-Theobald N; Linton GF; Loktionova NA; Pegg AE; Malech HL
    Exp Hematol; 2004 Aug; 32(8):709-19. PubMed ID: 15308322
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector.
    Sawai N; Zhou S; Vanin EF; Houghton P; Brent TP; Sorrentino BP
    Mol Ther; 2001 Jan; 3(1):78-87. PubMed ID: 11162314
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In vivo selection of transduced hematopoietic stem cells and little evidence of their conversion into hepatocytes in vivo.
    Yamaguchi K; Itoh K; Masuda T; Umemura A; Baum C; Itoh Y; Okanoue T; Fujita J
    J Hepatol; 2006 Nov; 45(5):681-7. PubMed ID: 16837099
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Lentiviral Transfer of γ-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine β-Thalassemia.
    Zhao HF; Abraham A; Kim YS; Wang YD; Pestina T; Zhan J; Humphries K; Nienhuis AW; Persons DA
    Mol Ther; 2017 Mar; 25(3):593-605. PubMed ID: 28190779
    [TBL] [Abstract][Full Text] [Related]  

  • 10. In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning.
    Zielske SP; Reese JS; Lingas KT; Donze JR; Gerson SL
    J Clin Invest; 2003 Nov; 112(10):1561-70. PubMed ID: 14617757
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients.
    Davis BM; Reese JS; Lingas K; Gerson SL
    J Hematother Stem Cell Res; 2003 Aug; 12(4):375-87. PubMed ID: 12965075
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide.
    Reese JS; Davis BM; Liu L; Gerson SL
    Clin Cancer Res; 1999 Jan; 5(1):163-9. PubMed ID: 9918215
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells.
    Fontes AM; Davis BM; Encell LP; Lingas K; Covas DT; Zago MA; Loeb LA; Pegg AE; Gerson SL
    Mol Cancer Ther; 2006 Jan; 5(1):121-8. PubMed ID: 16432170
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment.
    Maze R; Kurpad C; Pegg AE; Erickson LC; Williams DA
    J Pharmacol Exp Ther; 1999 Sep; 290(3):1467-74. PubMed ID: 10454526
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication.
    Davis BM; Humeau L; Dropulic B
    Mol Ther; 2004 Feb; 9(2):160-72. PubMed ID: 14759800
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterisation of a P140K mutant O6-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow.
    Kramer BA; Lemckert FA; Alexander IE; Gunning PW; McCowage GB
    J Gene Med; 2006 Sep; 8(9):1071-85. PubMed ID: 16927363
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection.
    Richard E; Robert E; Cario-André M; Ged C; Géronimi F; Gerson SL; de Verneuil H; Moreau-Gaudry F
    Gene Ther; 2004 Nov; 11(22):1638-47. PubMed ID: 15284838
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones.
    Jansen M; Bardenheuer W; Sorg UR; Seeber S; Flasshove M; Moritz T
    Eur J Haematol; 2001 Jul; 67(1):2-13. PubMed ID: 11553261
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O(6)-methylguanine-DNA methyltransferase(P140K).
    Maier P; Spier I; Laufs S; Veldwijk MR; Fruehauf S; Wenz F; Zeller WJ
    Gene Ther; 2010 Mar; 17(3):389-99. PubMed ID: 19865182
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro.
    Zielske SP; Gerson SL
    Mol Ther; 2002 Apr; 5(4):381-7. PubMed ID: 11945064
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.