141 related articles for article (PubMed ID: 12663521)
1. Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2.
Kimura S; Kawabe M; Yu A; Morishima H; Fernandez-Salguero P; Hammons GJ; Ward JM; Kadlubar FF; Gonzalez FJ
Carcinogenesis; 2003 Mar; 24(3):583-7. PubMed ID: 12663521
[TBL] [Abstract][Full Text] [Related]
2. A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach.
Chen C; Ma X; Malfatti MA; Krausz KW; Kimura S; Felton JS; Idle JR; Gonzalez FJ
Chem Res Toxicol; 2007 Mar; 20(3):531-42. PubMed ID: 17279779
[TBL] [Abstract][Full Text] [Related]
3. Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.
Cheung C; Ma X; Krausz KW; Kimura S; Feigenbaum L; Dalton TP; Nebert DW; Idle JR; Gonzalez FJ
Chem Res Toxicol; 2005 Sep; 18(9):1471-8. PubMed ID: 16167840
[TBL] [Abstract][Full Text] [Related]
4. Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human cytochrome P4501A1, P4501A2 and P4501B1.
Crofts FG; Sutter TR; Strickland PT
Carcinogenesis; 1998 Nov; 19(11):1969-73. PubMed ID: 9855011
[TBL] [Abstract][Full Text] [Related]
5. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is a potent mutagen in the mouse small intestine.
Brooks RA; Gooderham NJ; Zhao K; Edwards RJ; Howard LA; Boobis AR; Winton DJ
Cancer Res; 1994 Apr; 54(7):1665-71. PubMed ID: 8137279
[TBL] [Abstract][Full Text] [Related]
6. Activation and effects of the food-derived heterocyclic amines in extrahepatic tissues.
Overvik E; Hellmold H; Branting C; Gustafsson JA
Princess Takamatsu Symp; 1995; 23():123-33. PubMed ID: 8844803
[TBL] [Abstract][Full Text] [Related]
7. Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- mice.
Klein JC; Beems RB; Zwart PE; Hamzink M; Zomer G; van Steeg H; van Kreijl CF
Carcinogenesis; 2001 Apr; 22(4):619-26. PubMed ID: 11285198
[TBL] [Abstract][Full Text] [Related]
8. The impact of glucuronidation on the bioactivation and DNA adduction of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in vivo.
Malfatti MA; Ubick EA; Felton JS
Carcinogenesis; 2005 Nov; 26(11):2019-28. PubMed ID: 15944213
[TBL] [Abstract][Full Text] [Related]
9. Effect of CYP1A2 deficiency on heterocyclic amine DNA adduct levels in mice.
Snyderwine EG; Yu M; Schut HA; Knight-Jones L; Kimura S
Food Chem Toxicol; 2002 Oct; 40(10):1529-33. PubMed ID: 12387319
[TBL] [Abstract][Full Text] [Related]
10. Neonatal exposure to the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine via breast milk or directly induces intestinal tumors in multiple intestinal neoplasia mice.
Paulsen JE; Steffensen IL; Andreassen A; Vikse R; Alexander J
Carcinogenesis; 1999 Jul; 20(7):1277-82. PubMed ID: 10383901
[TBL] [Abstract][Full Text] [Related]
11. Dose validation of PhIP hair level as a biomarker of heterocyclic aromatic amines exposure: a feeding study.
Le Marchand L; Yonemori K; White KK; Franke AA; Wilkens LR; Turesky RJ
Carcinogenesis; 2016 Jul; 37(7):685-691. PubMed ID: 27207666
[TBL] [Abstract][Full Text] [Related]
12. 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced DNA adducts and genotoxicity in chinese hamster ovary (CHO) cells expressing human CYP1A2 and rapid or slow acetylator N-acetyltransferase 2.
Metry KJ; Zhao S; Neale JR; Doll MA; States JC; McGregor WG; Pierce WM; Hein DW
Mol Carcinog; 2007 Jul; 46(7):553-63. PubMed ID: 17295238
[TBL] [Abstract][Full Text] [Related]
13. Cytochrome P450 expression and metabolic activation of cooked food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in MCF10A breast epithelial cells.
Thomas RD; Green MR; Wilson C; Weckle AL; Duanmu Z; Kocarek TA; Runge-Morris M
Chem Biol Interact; 2006 Apr; 160(3):204-16. PubMed ID: 16527260
[TBL] [Abstract][Full Text] [Related]
14. The identification of [2-(14)C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans.
Malfatti MA; Kulp KS; Knize MG; Davis C; Massengill JP; Williams S; Nowell S; MacLeod S; Dingley KH; Turteltaub KW; Lang NP; Felton JS
Carcinogenesis; 1999 Apr; 20(4):705-13. PubMed ID: 10223203
[TBL] [Abstract][Full Text] [Related]
15. The dietary carcinogen PhIP activates p53-dependent DNA damage response in the colon of CYP1A-humanized mice.
Yang X; Peng H; Luo Z; Luo A; Cai M; Xu L; Wang H
Biofactors; 2021 Jul; 47(4):612-626. PubMed ID: 33811687
[TBL] [Abstract][Full Text] [Related]
16. CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice.
Kimura S; Kawabe M; Ward JM; Morishima H; Kadlubar FF; Hammons GJ; Fernandez-Salguero P; Gonzalez FJ
Carcinogenesis; 1999 Sep; 20(9):1825-30. PubMed ID: 10469630
[TBL] [Abstract][Full Text] [Related]
17. Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Ma X; Idle JR; Malfatti MA; Krausz KW; Nebert DW; Chen CS; Felton JS; Waxman DJ; Gonzalez FJ
Carcinogenesis; 2007 Mar; 28(3):732-7. PubMed ID: 17052995
[TBL] [Abstract][Full Text] [Related]
18. The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines.
Yueh MF; Nguyen N; Famourzadeh M; Strassburg CP; Oda Y; Guengerich FP; Tukey RH
Carcinogenesis; 2001 Jun; 22(6):943-50. PubMed ID: 11375903
[TBL] [Abstract][Full Text] [Related]
19. Excretion of the N(2)-glucuronide conjugate of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in urine and its relationship to CYP1A2 and NAT2 activity levels in humans.
Stillwell WG; Sinha R; Tannenbaum SR
Carcinogenesis; 2002 May; 23(5):831-8. PubMed ID: 12016157
[TBL] [Abstract][Full Text] [Related]
20. Urinary excretion of unmetabolized and phase II conjugates of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans: relationship to cytochrome P4501A2 and N-acetyltransferase activity.
Stillwell WG; Kidd LC; Wishnok JS; Tannenbaum SR; Sinha R
Cancer Res; 1997 Aug; 57(16):3457-64. PubMed ID: 9270013
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]