257 related articles for article (PubMed ID: 12665519)
1. Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.
Shi XP; Tugusheva K; Bruce JE; Lucka A; Wu GX; Chen-Dodson E; Price E; Li Y; Xu M; Huang Q; Sardana MK; Hazuda DJ
J Biol Chem; 2003 Jun; 278(23):21286-94. PubMed ID: 12665519
[TBL] [Abstract][Full Text] [Related]
2. RNA aptamers selectively modulate protein recruitment to the cytoplasmic domain of beta-secretase BACE1 in vitro.
Rentmeister A; Bill A; Wahle T; Walter J; Famulok M
RNA; 2006 Sep; 12(9):1650-60. PubMed ID: 16888322
[TBL] [Abstract][Full Text] [Related]
3. Beta-secretase: structure, function, and evolution.
Venugopal C; Demos CM; Rao KS; Pappolla MA; Sambamurti K
CNS Neurol Disord Drug Targets; 2008 Jun; 7(3):278-94. PubMed ID: 18673212
[TBL] [Abstract][Full Text] [Related]
4. Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.
Kitazume S; Tachida Y; Oka R; Shirotani K; Saido TC; Hashimoto Y
Proc Natl Acad Sci U S A; 2001 Nov; 98(24):13554-9. PubMed ID: 11698669
[TBL] [Abstract][Full Text] [Related]
5. Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.
Kukar TL; Ladd TB; Robertson P; Pintchovski SA; Moore B; Bann MA; Ren Z; Jansen-West K; Malphrus K; Eggert S; Maruyama H; Cottrell BA; Das P; Basi GS; Koo EH; Golde TE
J Biol Chem; 2011 Nov; 286(46):39804-12. PubMed ID: 21868378
[TBL] [Abstract][Full Text] [Related]
6. The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.
Vassar R; Kovacs DM; Yan R; Wong PC
J Neurosci; 2009 Oct; 29(41):12787-94. PubMed ID: 19828790
[TBL] [Abstract][Full Text] [Related]
7. Enhanced cleavage of APP by co-expressed Bace1 alters the distribution of APP and its fragments in neuronal and non-neuronal cells.
Aow J; Huang TR; Thinakaran G; Koo EH
Mol Neurobiol; 2022 May; 59(5):3073-3090. PubMed ID: 35266114
[TBL] [Abstract][Full Text] [Related]
8. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.
Vassar R; Kuhn PH; Haass C; Kennedy ME; Rajendran L; Wong PC; Lichtenthaler SF
J Neurochem; 2014 Jul; 130(1):4-28. PubMed ID: 24646365
[TBL] [Abstract][Full Text] [Related]
9. Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease.
Hook V; Hook G; Kindy M
Biol Chem; 2010 Aug; 391(8):861-72. PubMed ID: 20536395
[TBL] [Abstract][Full Text] [Related]
10. Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations.
Chami L; Buggia-Prévot V; Duplan E; Del Prete D; Chami M; Peyron JF; Checler F
J Biol Chem; 2012 Jul; 287(29):24573-84. PubMed ID: 22654105
[TBL] [Abstract][Full Text] [Related]
11. Characterizing the transmembrane domains of ADAM10 and BACE1 and the impact of membrane composition.
Abraham CB; Xu L; Pantelopulos GA; Straub JE
Biophys J; 2023 Oct; 122(19):3999-4010. PubMed ID: 37658602
[TBL] [Abstract][Full Text] [Related]
12. Amino acid sequence and structural comparison of BACE1 and BACE2 using evolutionary trace method.
Mirsafian H; Mat Ripen A; Merican AF; Bin Mohamad S
ScientificWorldJournal; 2014; 2014():482463. PubMed ID: 25254246
[TBL] [Abstract][Full Text] [Related]
13. Partial reduction of amyloid β production by β-secretase inhibitors does not decrease synaptic transmission.
Satir TM; Agholme L; Karlsson A; Karlsson M; Karila P; Illes S; Bergström P; Zetterberg H
Alzheimers Res Ther; 2020 May; 12(1):63. PubMed ID: 32456694
[TBL] [Abstract][Full Text] [Related]
14. An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.
Sala Frigerio C; Kukar TL; Fauq A; Engel PC; Golde TE; Walsh DM
Biochemistry; 2009 Nov; 48(46):10894-904. PubMed ID: 19821615
[TBL] [Abstract][Full Text] [Related]
15. Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production.
Shimizu H; Tosaki A; Kaneko K; Hisano T; Sakurai T; Nukina N
Mol Cell Biol; 2008 Jun; 28(11):3663-71. PubMed ID: 18378702
[TBL] [Abstract][Full Text] [Related]
16. Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.
Yan R; Fan Q; Zhou J; Vassar R
Neurosci Biobehav Rev; 2016 Jun; 65():326-40. PubMed ID: 27044452
[TBL] [Abstract][Full Text] [Related]
17. Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease.
Jeppsson F; Eketjäll S; Janson J; Karlström S; Gustavsson S; Olsson LL; Radesäter AC; Ploeger B; Cebers G; Kolmodin K; Swahn BM; von Berg S; Bueters T; Fälting J
J Biol Chem; 2012 Nov; 287(49):41245-57. PubMed ID: 23048024
[TBL] [Abstract][Full Text] [Related]
18. Substrate specificity of gamma-secretase and other intramembrane proteases.
Beel AJ; Sanders CR
Cell Mol Life Sci; 2008 May; 65(9):1311-34. PubMed ID: 18239854
[TBL] [Abstract][Full Text] [Related]
19. The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid.
Verdile G; Gandy SE; Martins RN
Neurochem Res; 2007; 32(4-5):609-23. PubMed ID: 16944319
[TBL] [Abstract][Full Text] [Related]
20. Identification of small molecules and related targets that modulate tau pathology in a seeded primary neuron model.
Gibbons GS; Gould H; Lee VM; Crowe A; Brunden KR
J Biol Chem; 2023 Jul; 299(7):104876. PubMed ID: 37269953
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
