124 related articles for article (PubMed ID: 12678736)
1. Recent advances in the chemistry and biology of folypoly-gamma-glutamate synthetase substrates and inhibitors.
Gangjee A; Dubash NP; Zeng Y; McGuire JJ
Curr Med Chem Anticancer Agents; 2002 May; 2(3):331-55. PubMed ID: 12678736
[TBL] [Abstract][Full Text] [Related]
2. Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
Liani E; Rothem L; Bunni MA; Smith CA; Jansen G; Assaraf YG
Int J Cancer; 2003 Feb; 103(5):587-99. PubMed ID: 12494465
[TBL] [Abstract][Full Text] [Related]
3. Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I.
Gangjee A; Jain HD; Kurup S
Anticancer Agents Med Chem; 2007 Sep; 7(5):524-42. PubMed ID: 17896913
[TBL] [Abstract][Full Text] [Related]
4. Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer.
Raz S; Stark M; Assaraf YG
Drug Resist Updat; 2016 Sep; 28():43-64. PubMed ID: 27620954
[TBL] [Abstract][Full Text] [Related]
5. Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: Part II.
Gangjee A; Jain HD; Kurup S
Anticancer Agents Med Chem; 2008 Feb; 8(2):205-31. PubMed ID: 18288923
[TBL] [Abstract][Full Text] [Related]
6. Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate.
Sohn KJ; Smirnakis F; Moskovitz DN; Novakovic P; Yates Z; Lucock M; Croxford R; Kim YI
Gut; 2004 Dec; 53(12):1825-31. PubMed ID: 15542523
[TBL] [Abstract][Full Text] [Related]
7. Exploitation of folate and antifolate polyglutamylation to achieve selective anticancer chemotherapy.
McGuire JJ; Tsukamoto T; Hart BP; Coward JK; Kalman TI; Galivan J
Invest New Drugs; 1996; 14(3):317-23. PubMed ID: 8958187
[TBL] [Abstract][Full Text] [Related]
8. 5-Arylthio-substituted 2-amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine antifolates as thymidylate synthase inhibitors and antitumor agents.
Gangjee A; Devraj R; McGuire JJ; Kisliuk RL
J Med Chem; 1995 Oct; 38(22):4495-502. PubMed ID: 7473577
[TBL] [Abstract][Full Text] [Related]
9. A strategy for the design of membrane-permeable folypoly-gamma-glutamate synthetase inhibitors: "bay-region"-substituted 2-desamino-2-methyl-5,8-dideazafolate analogs.
Sanghani PC; Jackman A; Evans VR; Thornton T; Hughes L; Calvert AH; Moran RG
Mol Pharmacol; 1994 Feb; 45(2):341-51. PubMed ID: 8114682
[TBL] [Abstract][Full Text] [Related]
10. Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cells.
Cho RC; Cole PD; Sohn KJ; Gaisano G; Croxford R; Kamen BA; Kim YI
Mol Cancer Ther; 2007 Nov; 6(11):2909-20. PubMed ID: 18025275
[TBL] [Abstract][Full Text] [Related]
11. Mechanism-based inhibition of human folylpolyglutamate synthetase: design, synthesis, and biochemical characterization of a phosphapeptide mimic of the tetrahedral intermediate.
Tsukamoto T; Haile WH; McGuire JJ; Coward JK
Arch Biochem Biophys; 1998 Jul; 355(1):109-18. PubMed ID: 9647673
[TBL] [Abstract][Full Text] [Related]
12. Roles of folylpoly-gamma-glutamate synthetase in therapeutics with tetrahydrofolate antimetabolites: an overview.
Moran RG
Semin Oncol; 1999 Apr; 26(2 Suppl 6):24-32. PubMed ID: 10598551
[TBL] [Abstract][Full Text] [Related]
13. Enzymes involved in folate metabolism and its implication for cancer treatment.
Kim SE
Nutr Res Pract; 2020 Apr; 14(2):95-101. PubMed ID: 32256983
[TBL] [Abstract][Full Text] [Related]
14. Regulation of folate and one-carbon metabolism in mammalian cells. II. Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpoly-gamma-glutamate specificity of metabolic cycles of one-carbon metabolism.
Lowe KE; Osborne CB; Lin BF; Kim JS; Hsu JC; Shane B
J Biol Chem; 1993 Oct; 268(29):21665-73. PubMed ID: 8408019
[TBL] [Abstract][Full Text] [Related]
15. Effects of antisense-based folypoly-gamma-glutamate synthetase down-regulation on reduced folates and cellular proliferation in CCRF-CEM cells.
Liu Y; Raghunathan K; Hill C; He Y; Bunni MA; Barredo J; Priest DG
Biochem Pharmacol; 1998 Jun; 55(12):2031-7. PubMed ID: 9714324
[TBL] [Abstract][Full Text] [Related]
16. Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.
Stark M; Wichman C; Avivi I; Assaraf YG
Blood; 2009 Apr; 113(18):4362-9. PubMed ID: 19131550
[TBL] [Abstract][Full Text] [Related]
17. Inhibition of human liver folylpolyglutamate synthetase by non-gamma-glutamylatable antifolate analogs.
Clarke L; Rosowsky A; Waxman DJ
Mol Pharmacol; 1987 Jan; 31(1):122-7. PubMed ID: 3807889
[TBL] [Abstract][Full Text] [Related]
18. Folylpoly-gamma-glutamate synthetase gene mRNA splice variants and protein expression in primary human leukemia cells, cell lines, and normal human tissues.
Leclerc GJ; Barredo JC
Clin Cancer Res; 2001 Apr; 7(4):942-51. PubMed ID: 11309345
[TBL] [Abstract][Full Text] [Related]
19. Folylpoly-gamma-glutamate synthetase: generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity.
Qi H; Atkinson I; Xiao S; Choi YJ; Tobimatsu T; Shane B
Adv Enzyme Regul; 1999; 39():263-73. PubMed ID: 10470377
[TBL] [Abstract][Full Text] [Related]
20. Regulation of folate and one-carbon metabolism in mammalian cells. I. Folate metabolism in Chinese hamster ovary cells expressing Escherichia coli or human folylpoly-gamma-glutamate synthetase activity.
Osborne CB; Lowe KE; Shane B
J Biol Chem; 1993 Oct; 268(29):21657-64. PubMed ID: 8408018
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]