272 related articles for article (PubMed ID: 12684521)
1. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.
Lai MT; Chen E; Crouthamel MC; DiMuzio-Mower J; Xu M; Huang Q; Price E; Register RB; Shi XP; Donoviel DB; Bernstein A; Hazuda D; Gardell SJ; Li YM
J Biol Chem; 2003 Jun; 278(25):22475-81. PubMed ID: 12684521
[TBL] [Abstract][Full Text] [Related]
2. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
[TBL] [Abstract][Full Text] [Related]
3. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
[TBL] [Abstract][Full Text] [Related]
4. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
[TBL] [Abstract][Full Text] [Related]
5. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.
Yonemura Y; Futai E; Yagishita S; Suo S; Tomita T; Iwatsubo T; Ishiura S
J Biol Chem; 2011 Dec; 286(52):44569-75. PubMed ID: 22074918
[TBL] [Abstract][Full Text] [Related]
6. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
Lai MT; Crouthamel MC; DiMuzio J; Pietrak BL; Donoviel DB; Bernstein A; Gardell SJ; Li YM; Hazuda D
J Neurochem; 2006 Jan; 96(1):118-25. PubMed ID: 16300640
[TBL] [Abstract][Full Text] [Related]
7. Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.
Evin G; Sharples RA; Weidemann A; Reinhard FB; Carbone V; Culvenor JG; Holsinger RM; Sernee MF; Beyreuther K; Masters CL
Biochemistry; 2001 Jul; 40(28):8359-68. PubMed ID: 11444983
[TBL] [Abstract][Full Text] [Related]
8. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
[TBL] [Abstract][Full Text] [Related]
9. Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
Stanga S; Vrancx C; Tasiaux B; Marinangeli C; Karlström H; Kienlen-Campard P
J Cell Mol Med; 2018 Feb; 22(2):823-833. PubMed ID: 28994238
[TBL] [Abstract][Full Text] [Related]
10. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
Kimberly WT; Xia W; Rahmati T; Wolfe MS; Selkoe DJ
J Biol Chem; 2000 Feb; 275(5):3173-8. PubMed ID: 10652302
[TBL] [Abstract][Full Text] [Related]
11. Quantitative comparison of presenilin protein expression reveals greater activity of PS2-γ-secretase.
Eccles MK; Main N; Carlessi R; Armstrong AM; Sabale M; Roberts-Mok B; Tirnitz-Parker JEE; Agostino M; Groth D; Fraser PE; Verdile G
FASEB J; 2024 Jan; 38(1):e23396. PubMed ID: 38156414
[TBL] [Abstract][Full Text] [Related]
12. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.
Zhang L; Lee J; Song L; Sun X; Shen J; Terracina G; Parker EM
Biochemistry; 2005 Mar; 44(11):4450-7. PubMed ID: 15766275
[TBL] [Abstract][Full Text] [Related]
13. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
[TBL] [Abstract][Full Text] [Related]
14. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
Steiner H; Capell A; Leimer U; Haass C
Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
[TBL] [Abstract][Full Text] [Related]
15. Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.
Lessard CB; Rodriguez E; Ladd TB; Minter LM; Osborne BA; Miele L; Golde TE; Ran Y
J Biol Chem; 2019 Jul; 294(29):11276-11285. PubMed ID: 31167792
[TBL] [Abstract][Full Text] [Related]
16. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
17. gamma-Secretase: characterization and implication for Alzheimer disease therapy.
Xu M; Lai MT; Huang Q; DiMuzio-Mower J; Castro JL; Harrison T; Nadin A; Neduvelil JG; Shearman MS; Shafer JA; Gardell SJ; Li YM
Neurobiol Aging; 2002; 23(6):1023-30. PubMed ID: 12470798
[TBL] [Abstract][Full Text] [Related]
18. Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.
Watanabe H; Imaizumi K; Cai T; Zhou Z; Tomita T; Okano H
eNeuro; 2021; 8(2):. PubMed ID: 33608391
[TBL] [Abstract][Full Text] [Related]
19. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
[TBL] [Abstract][Full Text] [Related]
20. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.
Li YM; Lai MT; Xu M; Huang Q; DiMuzio-Mower J; Sardana MK; Shi XP; Yin KC; Shafer JA; Gardell SJ
Proc Natl Acad Sci U S A; 2000 May; 97(11):6138-43. PubMed ID: 10801983
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
