147 related articles for article (PubMed ID: 12695348)
1. Influence of lipophilicity on the interactions of N-alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and their positively charged N-alkyl-4-phenylpyridinium metabolites with cytochrome P450 2D6.
Kalgutkar AS; Zhou S; Fahmi OA; Taylor TJ
Drug Metab Dispos; 2003 May; 31(5):596-605. PubMed ID: 12695348
[TBL] [Abstract][Full Text] [Related]
2. Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites.
Avent KM; DeVoss JJ; Gillam EM
Chem Res Toxicol; 2006 Jul; 19(7):914-20. PubMed ID: 16841959
[TBL] [Abstract][Full Text] [Related]
3. Long-term treatment with the tetrahydropyridine analog (HPTP) of haloperidol influences dopamine ligand binding in baboon brain. An [123I]iodobenzamide (IBZM) SPECT study.
Van der Schyf CJ; Dormehl IC; Oliver DW; Hugo N; Keeve R; Müller-Gärtner HW; Pond SM; Castagnoli N
Brain Res Mol Brain Res; 1996 Dec; 43(1-2):251-8. PubMed ID: 9037540
[TBL] [Abstract][Full Text] [Related]
4. Enzyme-catalyzed bioactivation of cyclic tertiary amines to form potential neurotoxins.
Castagnoli N; Castagnoli KP; Van der Schyf CJ; Usuki E; Igarashi K; Steyn SJ; Riker RR
Pol J Pharmacol; 1999; 51(1):31-8. PubMed ID: 10389142
[TBL] [Abstract][Full Text] [Related]
5. Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.
Herraiz T; Guillén H; Arán VJ; Idle JR; Gonzalez FJ
Toxicol Appl Pharmacol; 2006 Nov; 216(3):387-98. PubMed ID: 16870220
[TBL] [Abstract][Full Text] [Related]
6. Identification of an N-methyl-4-phenylpyridinium-like metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation event.
Kalgutkar AS; Nguyen HT
Drug Metab Dispos; 2004 Sep; 32(9):943-52. PubMed ID: 15319335
[TBL] [Abstract][Full Text] [Related]
7. Metabolic studies on haloperidol and its tetrahydropyridine analog in C57BL/6 mice.
Van der Schyf CJ; Castagnoli K; Usuki E; Fouda HG; Rimoldi JM; Castagnoli N
Chem Res Toxicol; 1994; 7(3):281-5. PubMed ID: 8075357
[TBL] [Abstract][Full Text] [Related]
8. Studies on the conversion of haloperidol and its tetrahydropyridine dehydration product to potentially neurotoxic pyridinium metabolites by human liver microsomes.
Usuki E; Pearce R; Parkinson A; Castagnol N
Chem Res Toxicol; 1996 Jun; 9(4):800-6. PubMed ID: 8831826
[TBL] [Abstract][Full Text] [Related]
9. Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).
Uehara S; Uno Y; Inoue T; Murayama N; Shimizu M; Sasaki E; Yamazaki H
Drug Metab Dispos; 2015 May; 43(5):735-42. PubMed ID: 25735838
[TBL] [Abstract][Full Text] [Related]
10. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a substrate of cytochrome P450 2D6: allosteric effects of NADPH-cytochrome P450 reductase.
Modi S; Gilham DE; Sutcliffe MJ; Lian LY; Primrose WU; Wolf CR; Roberts GC
Biochemistry; 1997 Apr; 36(15):4461-70. PubMed ID: 9109653
[TBL] [Abstract][Full Text] [Related]
11. Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.
Guengerich FP; Miller GP; Hanna IH; Martin MV; Léger S; Black C; Chauret N; Silva JM; Trimble LA; Yergey JA; Nicoll-Griffith DA
Biochemistry; 2002 Sep; 41(36):11025-34. PubMed ID: 12206675
[TBL] [Abstract][Full Text] [Related]
12. N-methyltetrahydro-beta-carboline analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin are oxidized to neurotoxic beta-carbolinium cations by heme peroxidases.
Herraiz T; Guillén H; Galisteo J
Biochem Biophys Res Commun; 2007 Apr; 356(1):118-23. PubMed ID: 17346675
[TBL] [Abstract][Full Text] [Related]
13. Structure-activity study of the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. II. Evaluation of the biological activity of the pyridinium metabolites formed from the monoamine oxidase-catalyzed oxidation of MPTP analogs.
Youngster SK; Nicklas WJ; Heikkila RE
J Pharmacol Exp Ther; 1989 Jun; 249(3):829-35. PubMed ID: 2786565
[TBL] [Abstract][Full Text] [Related]
14. Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.
Bajpai P; Sangar MC; Singh S; Tang W; Bansal S; Chowdhury G; Cheng Q; Fang JK; Martin MV; Guengerich FP; Avadhani NG
J Biol Chem; 2013 Feb; 288(6):4436-51. PubMed ID: 23258538
[TBL] [Abstract][Full Text] [Related]
15. Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells.
Mann A; Tyndale RF
Eur J Neurosci; 2010 Apr; 31(7):1185-93. PubMed ID: 20345925
[TBL] [Abstract][Full Text] [Related]
16. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.
Coleman T; Ellis SW; Martin IJ; Lennard MS; Tucker GT
J Pharmacol Exp Ther; 1996 May; 277(2):685-90. PubMed ID: 8627546
[TBL] [Abstract][Full Text] [Related]
17. Influence of N-substitution of 7-methoxy-4-(aminomethyl)-coumarin on cytochrome P450 metabolism and selectivity.
Venhorst J; Onderwater RC; Meerman JH; Commandeur JN; Vermeulen NP
Drug Metab Dispos; 2000 Dec; 28(12):1524-32. PubMed ID: 11095593
[TBL] [Abstract][Full Text] [Related]
18. Dopamine receptor binding of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)- 4-oxobutyl]-1,2,3,6-tetrahydropyridine (HPTP), an intermediate metabolite of haloperidol.
Brand L; Oliver DW; van der Schyf CJ; Pond SM; Castagnoli N
Life Sci; 1996; 59(10):815-20. PubMed ID: 8761315
[TBL] [Abstract][Full Text] [Related]
19. MPP(+)-like neurotoxicity of a pyridinium metabolite derived from haloperidol: in vivo microdialysis and in vitro mitochondrial studies.
Rollema H; Skolnik M; D'Engelbronner J; Igarashi K; Usuki E; Castagnoli N
J Pharmacol Exp Ther; 1994 Jan; 268(1):380-7. PubMed ID: 8301579
[TBL] [Abstract][Full Text] [Related]
20. On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: the effect of perinigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, its metabolite and their analogs in the rat.
Harik SI; Schmidley JW; Iacofano LA; Blue P; Arora PK; Sayre LM
J Pharmacol Exp Ther; 1987 May; 241(2):669-76. PubMed ID: 2437293
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]