BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

124 related articles for article (PubMed ID: 12699762)

  • 1. Design, synthesis, and activity of novel cis- and trans-3,6-disubstituted pyran biomimetics of 3,6-disubstituted piperidine as potential ligands for the dopamine transporter.
    Zhang S; Reith ME; Dutta AK
    Bioorg Med Chem Lett; 2003 May; 13(9):1591-5. PubMed ID: 12699762
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters.
    Kolhatkar R; Cook CD; Ghorai SK; Deschamps J; Beardsley PM; Reith ME; Dutta AK
    J Med Chem; 2004 Oct; 47(21):5101-13. PubMed ID: 15456254
    [TBL] [Abstract][Full Text] [Related]  

  • 3. High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo.
    Ghorai SK; Cook C; Davis M; Venkataraman SK; George C; Beardsley PM; Reith ME; Dutta AK
    J Med Chem; 2003 Mar; 46(7):1220-8. PubMed ID: 12646032
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Chemistry and pharmacology of the piperidine-based analogues of cocaine. Identification of potent DAT inhibitors lacking the tropane skeleton.
    Kozikowski AP; Araldi GL; Boja J; Meil WM; Johnson KM; Flippen-Anderson JL; George C; Saiah E
    J Med Chem; 1998 May; 41(11):1962-9. PubMed ID: 9599245
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors.
    Tamiz AP; Zhang J; Flippen-Anderson JL; Zhang M; Johnson KM; Deschaux O; Tella S; Kozikowski AP
    J Med Chem; 2000 Mar; 43(6):1215-22. PubMed ID: 10737754
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter.
    Dutta AK; Xu C; Reith ME
    J Med Chem; 1998 Aug; 41(17):3293-7. PubMed ID: 9703474
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine.
    Kolhatkar RB; Ghorai SK; George C; Reith ME; Dutta AK
    J Med Chem; 2003 May; 46(11):2205-15. PubMed ID: 12747792
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters.
    Zhang S; Fernandez F; Hazeldine S; Deschamps J; Zhen J; Reith ME; Dutta AK
    J Med Chem; 2006 Jul; 49(14):4239-47. PubMed ID: 16821783
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters.
    Zhang S; Zhen J; Reith ME; Dutta AK
    Bioorg Med Chem; 2004 Dec; 12(23):6301-15. PubMed ID: 15519172
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters.
    Dutta AK; Fei XS; Beardsley PM; Newman JL; Reith ME
    J Med Chem; 2001 Mar; 44(6):937-48. PubMed ID: 11300876
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter.
    Dutta AK; Davis MC; Reith ME
    Bioorg Med Chem Lett; 2001 Sep; 11(17):2337-40. PubMed ID: 11527726
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner.
    Zhang S; Zhen J; Reith ME; Dutta AK
    J Med Chem; 2005 Jul; 48(15):4962-71. PubMed ID: 16033275
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Syntheses of 3-carbomethoxy-4-(aryl)piperidines and in vitro and in vivo pharmacological evaluation: identification of inhibitors of the human dopamine transporter.
    Feng X; Fandrick K; Johnson R; Janowsky A; Cashman JR
    Bioorg Med Chem; 2003 Mar; 11(5):775-80. PubMed ID: 12538008
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.
    Greiner E; Prisinzano T; Johnson EM; Dersch CM; Marcus J; Partilla JS; Rothman RB; Jacobson AE; Rice KC
    J Med Chem; 2003 Apr; 46(8):1465-9. PubMed ID: 12672246
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies.
    Wang S; Sakamuri S; Enyedy IJ; Kozikowski AP; Deschaux O; Bandyopadhyay BC; Tella SR; Zaman WA; Johnson KM
    J Med Chem; 2000 Feb; 43(3):351-60. PubMed ID: 10669562
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues.
    Dutta AK; Coffey LL; Reith ME
    J Med Chem; 1998 Feb; 41(5):699-705. PubMed ID: 9513598
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate.
    Meltzer PC; Wang P; Blundell P; Madras BK
    J Med Chem; 2003 Apr; 46(8):1538-45. PubMed ID: 12672255
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and characterization of a novel, 4-[2-(diphenylmethoxy)ethyl]-1-benzyl piperidine-based, dopamine transporter photoaffinity label.
    Dutta AK; Fei XS; Vaughan RA; Gaffaney JD; Wang N; Lever JR; Reith ME
    Life Sci; 2001 Mar; 68(16):1839-49. PubMed ID: 11292062
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules.
    Dutta AK; Davis MC; Fei XS; Beardsley PM; Cook CD; Reith ME
    J Med Chem; 2002 Jan; 45(3):654-62. PubMed ID: 11806716
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter.
    Simoni D; Rossi M; Bertolasi V; Roberti M; Pizzirani D; Rondanin R; Baruchello R; Invidiata FP; Tolomeo M; Grimaudo S; Merighi S; Varani K; Gessi S; Borea PA; Marino S; Cavallini S; Bianchi C; Siniscalchi A
    J Med Chem; 2005 May; 48(9):3337-43. PubMed ID: 15857139
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.