276 related articles for article (PubMed ID: 12702506)
1. Survival of acute myeloid leukemia cells requires PI3 kinase activation.
Xu Q; Simpson SE; Scialla TJ; Bagg A; Carroll M
Blood; 2003 Aug; 102(3):972-80. PubMed ID: 12702506
[TBL] [Abstract][Full Text] [Related]
2. PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways.
Grandage VL; Gale RE; Linch DC; Khwaja A
Leukemia; 2005 Apr; 19(4):586-94. PubMed ID: 15703783
[TBL] [Abstract][Full Text] [Related]
3. Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR.
Dutton A; Reynolds GM; Dawson CW; Young LS; Murray PG
J Pathol; 2005 Mar; 205(4):498-506. PubMed ID: 15714459
[TBL] [Abstract][Full Text] [Related]
4. Constitutive NF-kappaB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway.
Birkenkamp KU; Geugien M; Schepers H; Westra J; Lemmink HH; Vellenga E
Leukemia; 2004 Jan; 18(1):103-12. PubMed ID: 14574326
[TBL] [Abstract][Full Text] [Related]
5. Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.
O'Gorman DM; McKenna SL; McGahon AJ; Knox KA; Cotter TG
Leukemia; 2000 Apr; 14(4):602-11. PubMed ID: 10764145
[TBL] [Abstract][Full Text] [Related]
6. 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways.
Guasch G; Ollendorff V; Borg JP; Birnbaum D; Pébusque MJ
Mol Cell Biol; 2001 Dec; 21(23):8129-42. PubMed ID: 11689702
[TBL] [Abstract][Full Text] [Related]
7. Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway.
Doepfner KT; Spertini O; Arcaro A
Leukemia; 2007 Sep; 21(9):1921-30. PubMed ID: 17581609
[TBL] [Abstract][Full Text] [Related]
8. Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia.
Sujobert P; Bardet V; Cornillet-Lefebvre P; Hayflick JS; Prie N; Verdier F; Vanhaesebroeck B; Muller O; Pesce F; Ifrah N; Hunault-Berger M; Berthou C; Villemagne B; Jourdan E; Audhuy B; Solary E; Witz B; Harousseau JL; Himberlin C; Lamy T; Lioure B; Cahn JY; Dreyfus F; Mayeux P; Lacombe C; Bouscary D
Blood; 2005 Aug; 106(3):1063-6. PubMed ID: 15840695
[TBL] [Abstract][Full Text] [Related]
9. Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.
Blalock WL; Navolanic PM; Steelman LS; Shelton JG; Moye PW; Lee JT; Franklin RA; Mirza A; McMahon M; White MK; McCubrey JA
Leukemia; 2003 Jun; 17(6):1058-67. PubMed ID: 12764369
[TBL] [Abstract][Full Text] [Related]
10. Inhibition of phosphatidylinositol 3'-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells.
Uddin S; Hussain AR; Al-Hussein KA; Manogaran PS; Wickrema A; Gutierrez MI; Bhatia KG
Clin Cancer Res; 2005 Apr; 11(8):3102-8. PubMed ID: 15837766
[TBL] [Abstract][Full Text] [Related]
11. Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.
Tamburini J; Chapuis N; Bardet V; Park S; Sujobert P; Willems L; Ifrah N; Dreyfus F; Mayeux P; Lacombe C; Bouscary D
Blood; 2008 Jan; 111(1):379-82. PubMed ID: 17878402
[TBL] [Abstract][Full Text] [Related]
12. Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development.
Burchert A; Wang Y; Cai D; von Bubnoff N; Paschka P; Müller-Brüsselbach S; Ottmann OG; Duyster J; Hochhaus A; Neubauer A
Leukemia; 2005 Oct; 19(10):1774-82. PubMed ID: 16136169
[TBL] [Abstract][Full Text] [Related]
13. Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells.
Weisberg E; Banerji L; Wright RD; Barrett R; Ray A; Moreno D; Catley L; Jiang J; Hall-Meyers E; Sauveur-Michel M; Stone R; Galinsky I; Fox E; Kung AL; Griffin JD
Blood; 2008 Apr; 111(7):3723-34. PubMed ID: 18184863
[TBL] [Abstract][Full Text] [Related]
14. The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad.
Shimamura H; Terada Y; Okado T; Tanaka H; Inoshita S; Sasaki S
J Am Soc Nephrol; 2003 Jun; 14(6):1427-34. PubMed ID: 12761242
[TBL] [Abstract][Full Text] [Related]
15. Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
Dai Y; Rahmani M; Pei XY; Khanna P; Han SI; Mitchell C; Dent P; Grant S
Blood; 2005 Feb; 105(4):1706-16. PubMed ID: 15494423
[TBL] [Abstract][Full Text] [Related]
16. PI3-kinase regulates survival of chronic lymphocytic leukemia B-cells by preventing caspase 8 activation.
Plate JM
Leuk Lymphoma; 2004 Aug; 45(8):1519-29. PubMed ID: 15370202
[TBL] [Abstract][Full Text] [Related]
17. Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production.
Salh B; Wagey R; Marotta A; Tao JS; Pelech S
J Immunol; 1998 Dec; 161(12):6947-54. PubMed ID: 9862729
[TBL] [Abstract][Full Text] [Related]
18. Emodin and Its Combination with Cytarabine Induce Apoptosis in Resistant Acute Myeloid Leukemia Cells in Vitro and in Vivo.
Chen Y; Gan D; Huang Q; Luo X; Lin D; Hu J
Cell Physiol Biochem; 2018; 48(5):2061-2073. PubMed ID: 30099447
[TBL] [Abstract][Full Text] [Related]
19. Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.
Zhao S; Konopleva M; Cabreira-Hansen M; Xie Z; Hu W; Milella M; Estrov Z; Mills GB; Andreeff M
Leukemia; 2004 Feb; 18(2):267-75. PubMed ID: 14628071
[TBL] [Abstract][Full Text] [Related]
20. Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts.
Tazzari PL; Cappellini A; Ricci F; Evangelisti C; Papa V; Grafone T; Martinelli G; Conte R; Cocco L; McCubrey JA; Martelli AM
Leukemia; 2007 Mar; 21(3):427-38. PubMed ID: 17215852
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
