These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

185 related articles for article (PubMed ID: 12723942)

  • 1. Design and synthesis of statine-based cell-permeable peptidomimetic inhibitors of human beta-secretase.
    Hom RK; Fang LY; Mamo S; Tung JS; Guinn AC; Walker DE; Davis DL; Gailunas AF; Thorsett ED; Sinha S; Knops JE; Jewett NE; Anderson JP; John V
    J Med Chem; 2003 May; 46(10):1799-802. PubMed ID: 12723942
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors.
    Hu B; Fan KY; Bridges K; Chopra R; Lovering F; Cole D; Zhou P; Ellingboe J; Jin G; Cowling R; Bard J
    Bioorg Med Chem Lett; 2004 Jul; 14(13):3457-60. PubMed ID: 15177452
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I; Hawkins J; Harrison D; Hille C; Wayne G; Cutler L; Buck T; Walter D; Demont E; Howes C; Naylor A; Jeffrey P; Gonzalez MI; Dingwall C; Michel A; Redshaw S; Davis JB
    J Neurochem; 2007 Feb; 100(3):802-9. PubMed ID: 17156133
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase.
    Hom RK; Gailunas AF; Mamo S; Fang LY; Tung JS; Walker DE; Davis D; Thorsett ED; Jewett NE; Moon JB; John V
    J Med Chem; 2004 Jan; 47(1):158-64. PubMed ID: 14695829
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site.
    Abbenante G; Kovacs DM; Leung DL; Craik DJ; Tanzi RE; Fairlie DP
    Biochem Biophys Res Commun; 2000 Feb; 268(1):133-5. PubMed ID: 10652226
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).
    Stachel SJ; Coburn CA; Steele TG; Jones KG; Loutzenhiser EF; Gregro AR; Rajapakse HA; Lai MT; Crouthamel MC; Xu M; Tugusheva K; Lineberger JE; Pietrak BL; Espeseth AS; Shi XP; Chen-Dodson E; Holloway MK; Munshi S; Simon AJ; Kuo L; Vacca JP
    J Med Chem; 2004 Dec; 47(26):6447-50. PubMed ID: 15588077
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues.
    Bäck M; Nyhlén J; Kvarnström I; Appelgren S; Borkakoti N; Jansson K; Lindberg J; Nyström S; Hallberg A; Rosenquist S; Samuelsson B
    Bioorg Med Chem; 2008 Nov; 16(21):9471-86. PubMed ID: 18842420
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core.
    Wångsell F; Gustafsson K; Kvarnström I; Borkakoti N; Edlund M; Jansson K; Lindberg J; Hallberg A; Rosenquist A; Samuelsson B
    Eur J Med Chem; 2010 Mar; 45(3):870-82. PubMed ID: 20036448
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase.
    Maillard MC; Hom RK; Benson TE; Moon JB; Mamo S; Bienkowski M; Tomasselli AG; Woods DD; Prince DB; Paddock DJ; Emmons TL; Tucker JA; Dappen MS; Brogley L; Thorsett ED; Jewett N; Sinha S; John V
    J Med Chem; 2007 Feb; 50(4):776-81. PubMed ID: 17300163
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
    Asai M; Hattori C; Iwata N; Saido TC; Sasagawa N; Szabó B; Hashimoto Y; Maruyama K; Tanuma S; Kiso Y; Ishiura S
    J Neurochem; 2006 Jan; 96(2):533-40. PubMed ID: 16336629
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design and synthesis of statine-containing BACE inhibitors.
    Hu J; Cwi CL; Smiley DL; Timm D; Erickson JA; McGee JE; Yang HC; Mendel D; May PC; Shapiro M; McCarthy JR
    Bioorg Med Chem Lett; 2003 Dec; 13(24):4335-9. PubMed ID: 14643321
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Macrocyclic peptidomimetic inhibitors of beta-secretase (BACE): first X-ray structure of a macrocyclic peptidomimetic-BACE complex.
    Rojo I; Martín JA; Broughton H; Timm D; Erickson J; Yang HC; McCarthy JR
    Bioorg Med Chem Lett; 2006 Jan; 16(1):191-5. PubMed ID: 16249081
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
    Baxter EW; Conway KA; Kennis L; Bischoff F; Mercken MH; Winter HL; Reynolds CH; Tounge BA; Luo C; Scott MK; Huang Y; Braeken M; Pieters SM; Berthelot DJ; Masure S; Bruinzeel WD; Jordan AD; Parker MH; Boyd RE; Qu J; Alexander RS; Brenneman DE; Reitz AB
    J Med Chem; 2007 Sep; 50(18):4261-4. PubMed ID: 17685503
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors.
    Hanessian S; Shao Z; Betschart C; Rondeau JM; Neumann U; Tintelnot-Blomley M
    Bioorg Med Chem Lett; 2010 Mar; 20(6):1924-7. PubMed ID: 20172717
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Calculation of the binding affinity of beta-secretase inhibitors using the linear interaction energy method.
    Tounge BA; Reynolds CH
    J Med Chem; 2003 May; 46(11):2074-82. PubMed ID: 12747779
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design of substrate-based inhibitors of human beta-secretase.
    Tung JS; Davis DL; Anderson JP; Walker DE; Mamo S; Jewett N; Hom RK; Sinha S; Thorsett ED; John V
    J Med Chem; 2002 Jan; 45(2):259-62. PubMed ID: 11784130
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.
    Machauer R; Veenstra S; Rondeau JM; Tintelnot-Blomley M; Betschart C; Neumann U; Paganetti P
    Bioorg Med Chem Lett; 2009 Mar; 19(5):1361-5. PubMed ID: 19195886
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.
    Stauffer SR; Stanton MG; Gregro AR; Steinbeiser MA; Shaffer JR; Nantermet PG; Barrow JC; Rittle KE; Collusi D; Espeseth AS; Lai MT; Pietrak BL; Holloway MK; McGaughey GB; Munshi SK; Hochman JH; Simon AJ; Selnick HG; Graham SL; Vacca JP
    Bioorg Med Chem Lett; 2007 Mar; 17(6):1788-92. PubMed ID: 17257835
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.
    Machauer R; Laumen K; Veenstra S; Rondeau JM; Tintelnot-Blomley M; Betschart C; Jaton AL; Desrayaud S; Staufenbiel M; Rabe S; Paganetti P; Neumann U
    Bioorg Med Chem Lett; 2009 Mar; 19(5):1366-70. PubMed ID: 19195887
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Stereochemical analysis of (hydroxyethyl)urea peptidomimetic inhibitors of gamma-secretase.
    Bakshi P; Wolfe MS
    J Med Chem; 2004 Dec; 47(26):6485-9. PubMed ID: 15588083
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.