115 related articles for article (PubMed ID: 12723950)
21. Hybrid ortho/allosteric ligands for the adenosine A(1) receptor.
Narlawar R; Lane JR; Doddareddy M; Lin J; Brussee J; Ijzerman AP
J Med Chem; 2010 Apr; 53(8):3028-37. PubMed ID: 20345101
[TBL] [Abstract][Full Text] [Related]
22. Synthesis and biological evaluation of novel allosteric enhancers of the A1 adenosine receptor based on 2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene.
Romagnoli R; Baraldi PG; IJzerman AP; Massink A; Cruz-Lopez O; Lopez-Cara LC; Saponaro G; Preti D; Aghazadeh Tabrizi M; Baraldi S; Moorman AR; Vincenzi F; Borea PA; Varani K
J Med Chem; 2014 Sep; 57(18):7673-86. PubMed ID: 25181013
[TBL] [Abstract][Full Text] [Related]
23. Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors.
van den Nieuwendijk AM; Pietra D; Heitman L; Göblyös A; IJzerman AP
J Med Chem; 2004 Jan; 47(3):663-72. PubMed ID: 14736246
[TBL] [Abstract][Full Text] [Related]
24. Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A₁ adenosine receptor.
Romagnoli R; Baraldi PG; Carrion MD; Cara CL; Cruz-Lopez O; Salvador MK; Preti D; Tabrizi MA; Shryock JC; Moorman AR; Vincenzi F; Varani K; Borea PA
Bioorg Med Chem; 2012 Jan; 20(2):996-1007. PubMed ID: 22182575
[TBL] [Abstract][Full Text] [Related]
25. N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.
Urwyler S; Pozza MF; Lingenhoehl K; Mosbacher J; Lampert C; Froestl W; Koller M; Kaupmann K
J Pharmacol Exp Ther; 2003 Oct; 307(1):322-30. PubMed ID: 12954816
[TBL] [Abstract][Full Text] [Related]
26. Synthesis and biological evaluation of a new series of 2,3,5-substituted [1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action.
Göblyös A; de Vries H; Brussee J; Ijzerman AP
J Med Chem; 2005 Feb; 48(4):1145-51. PubMed ID: 15715480
[TBL] [Abstract][Full Text] [Related]
27. Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study.
Romagnoli R; Baraldi PG; Lopez-Cara C; Cruz-Lopez O; Moorman AR; Massink A; IJzerman AP; Vincenzi F; Borea PA; Varani K
Eur J Med Chem; 2015 Aug; 101():185-204. PubMed ID: 26141910
[TBL] [Abstract][Full Text] [Related]
28. [3H]Org 43553, the first low-molecular-weight agonistic and allosteric radioligand for the human luteinizing hormone receptor.
Heitman LH; Oosterom J; Bonger KM; Timmers CM; Wiegerinck PH; Ijzerman AP
Mol Pharmacol; 2008 Feb; 73(2):518-24. PubMed ID: 17989351
[TBL] [Abstract][Full Text] [Related]
29. Allosteric modulation of the adenosine A(1) receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding.
van der Klein PA; Kourounakis AP; IJzerman AP
J Med Chem; 1999 Sep; 42(18):3629-35. PubMed ID: 10479294
[TBL] [Abstract][Full Text] [Related]
30. Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor.
Romagnoli R; Baraldi PG; Carrion MD; Cara CL; Cruz-Lopez O; Salvador MK; Preti D; Tabrizi MA; Moorman AR; Vincenzi F; Borea PA; Varani K
J Med Chem; 2012 Sep; 55(17):7719-35. PubMed ID: 22889387
[TBL] [Abstract][Full Text] [Related]
31. Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A(1) receptor.
Romagnoli R; Baraldi PG; Moorman AR; Iaconinoto MA; Carrion MD; Cara CL; Tabrizi MA; Preti D; Fruttarolo F; Baker SP; Varani K; Borea PA
Bioorg Med Chem Lett; 2006 Nov; 16(21):5530-3. PubMed ID: 16931014
[TBL] [Abstract][Full Text] [Related]
32. A1 adenosine receptor antagonists, agonists, and allosteric enhancers.
Kiesman WF; Elzein E; Zablocki J
Handb Exp Pharmacol; 2009; (193):25-58. PubMed ID: 19639278
[TBL] [Abstract][Full Text] [Related]
33. Synthesis and pharmacology of pyrido[2,3-d]pyrimidinediones bearing polar substituents as adenosine receptor antagonists.
Bulicz J; Bertarelli DC; Baumert D; Fülle F; Müller CE; Heber D
Bioorg Med Chem; 2006 Apr; 14(8):2837-49. PubMed ID: 16377196
[TBL] [Abstract][Full Text] [Related]
34. Synthesis and biological evaluation of 2-aminothiazoles and their amide derivatives on human adenosine receptors. Lack of effect of 2-aminothiazoles as allosteric enhancers.
Göblyös A; Santiago SN; Pietra D; Mulder-Krieger T; von Frijtag Drabbe Künzel J; Brussee J; Ijzerman AP
Bioorg Med Chem; 2005 Mar; 13(6):2079-87. PubMed ID: 15727861
[TBL] [Abstract][Full Text] [Related]
35. The allosteric enhancer, PD 81,723, stabilizes human A1 adenosine receptor coupling to G proteins.
Bhattacharya S; Linden J
Biochim Biophys Acta; 1995 Feb; 1265(1):15-21. PubMed ID: 7857979
[TBL] [Abstract][Full Text] [Related]
36. Pharmacological characterisation and inhibitory effects of (2R,3R,4S,5R)-2-(6-amino-2-{[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]amino}-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-furandiol, a novel ligand that demonstrates both adenosine A(2A) receptor agonist and adenosine A(3) receptor antagonist activity.
Bevan N; Butchers PR; Cousins R; Coates J; Edgar EV; Morrison V; Sheehan MJ; Reeves J; Wilson DJ
Eur J Pharmacol; 2007 Jun; 564(1-3):219-25. PubMed ID: 17382926
[TBL] [Abstract][Full Text] [Related]
37. Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.
Baraldi PG; Tabrizi MA; Preti D; Bovero A; Romagnoli R; Fruttarolo F; Zaid NA; Moorman AR; Varani K; Gessi S; Merighi S; Borea PA
J Med Chem; 2004 Mar; 47(6):1434-47. PubMed ID: 14998332
[TBL] [Abstract][Full Text] [Related]
38. Substituted terphenyl compounds as the first class of low molecular weight allosteric inhibitors of the luteinizing hormone receptor.
Heitman LH; Narlawar R; de Vries H; Willemsen MN; Wolfram D; Brussee J; Ijzerman AP
J Med Chem; 2009 Apr; 52(7):2036-42. PubMed ID: 19296599
[TBL] [Abstract][Full Text] [Related]
39. Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.
Yan L; Müller CE
J Med Chem; 2004 Feb; 47(4):1031-43. PubMed ID: 14761205
[TBL] [Abstract][Full Text] [Related]
40. The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor.
Sato M; Hutchinson DS; Evans BA; Summers RJ
Mol Pharmacol; 2008 Nov; 74(5):1417-28. PubMed ID: 18684840
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
