187 related articles for article (PubMed ID: 12727789)
1. Variability and regulation of O6-alkylguanine-DNA alkyltransferase.
Margison GP; Povey AC; Kaina B; Santibáñez Koref MF
Carcinogenesis; 2003 Apr; 24(4):625-35. PubMed ID: 12727789
[TBL] [Abstract][Full Text] [Related]
2. O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy.
Margison GP; Santibáñez-Koref MF
Bioessays; 2002 Mar; 24(3):255-66. PubMed ID: 11891762
[TBL] [Abstract][Full Text] [Related]
3. The potential role of glycine-160 of human O6-alkylguanine-DNA alkyltransferase in reaction with O6-benzylguanine as determined by site-directed mutagenesis and molecular modelling comparisons.
Rafferty JA; Wibley JE; Speers P; Hickson I; Margison GP; Moody PC; Douglas KT
Biochim Biophys Acta; 1997 Sep; 1342(1):90-102. PubMed ID: 9366274
[TBL] [Abstract][Full Text] [Related]
4. Differential expression of the O6-alkylguanine-DNA alkyltransferase gene in normal human breast and skin tissue: in situ mapping of cell type-specific expression.
Wani G; D'Ambrosio SM
Mol Carcinog; 1995 Mar; 12(3):177-84. PubMed ID: 7893370
[TBL] [Abstract][Full Text] [Related]
5. Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA.
Kooistra R; Zonneveld JB; Watson AJ; Margison GP; Lohman PH; Pastink A
Nucleic Acids Res; 1999 Apr; 27(8):1795-801. PubMed ID: 10101186
[TBL] [Abstract][Full Text] [Related]
6. Expression in mammalian cells of a truncated Escherichia coli gene coding for O6-alkylguanine alkyltransferase reduces the toxic effects of alkylating agents.
Brennand J; Margison GP
Carcinogenesis; 1986 Dec; 7(12):2081-4. PubMed ID: 3536143
[TBL] [Abstract][Full Text] [Related]
7. The alleles of the DNA repair gene O6-alkylguanine-DNA alkyltransferase are expressed at different levels in normal human lung tissue.
Heighway J; Margison GP; Santibáñez-Koref MF
Carcinogenesis; 2003 Oct; 24(10):1691-4. PubMed ID: 12896905
[TBL] [Abstract][Full Text] [Related]
8. Cell type-specific expression of the O6-alkylguanine-DNA alkyltransferase gene in normal human liver tissues as revealed by in situ hybridization.
Wani G; Wani AA; D'Ambrosio SM
Carcinogenesis; 1993 Apr; 14(4):737-41. PubMed ID: 8472340
[TBL] [Abstract][Full Text] [Related]
9. Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue: O(6)-methylguanine levels are associated with GSTT1 genotype and O(6)-alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype.
Povey AC; Hall CN; Badawi AF; Cooper DP; Guppy MJ; Jackson PE; O'Connor PJ; Margison GP
Mutat Res; 2001 Aug; 495(1-2):103-15. PubMed ID: 11448648
[TBL] [Abstract][Full Text] [Related]
10. Heterogeneity of O6-alkylguanine DNA-alkyltransferase expression in human breast tumours.
Clemons MJ; Bibby MC; El Teraifi H; Forster G; Kelly J; Banerjee S; Cadman B; Ryder WD; Howell A; Margison GP
Br J Cancer; 2002 Jun; 86(11):1797-802. PubMed ID: 12087469
[TBL] [Abstract][Full Text] [Related]
11. Polar, functionalized guanine-O6 derivatives resistant to repair by O6-alkylguanine-DNA alkyltransferase: implications for the design of DNA-modifying drugs.
Pletsas D; Wheelhouse RT; Pletsa V; Nicolaou A; Jenkins TC; Bibby MC; Kyrtopoulos SA
Eur J Med Chem; 2006 Mar; 41(3):330-9. PubMed ID: 16458393
[TBL] [Abstract][Full Text] [Related]
12. O6-alkylguanine-DNA alkyltransferase inactivation in cancer chemotherapy.
McElhinney RS; McMurry TB; Margison GP
Mini Rev Med Chem; 2003 Aug; 3(5):471-85. PubMed ID: 12769698
[TBL] [Abstract][Full Text] [Related]
13. Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase.
Wibley JE; Pegg AE; Moody PC
Nucleic Acids Res; 2000 Jan; 28(2):393-401. PubMed ID: 10606635
[TBL] [Abstract][Full Text] [Related]
14. Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC-->AT transition in the K-ras oncogene.
Jackson PE; Hall CN; O'Connor PJ; Cooper DP; Margison GP; Povey AC
Carcinogenesis; 1997 Jul; 18(7):1299-302. PubMed ID: 9230271
[TBL] [Abstract][Full Text] [Related]
15. Increasing DNA repair capacity in bone marrow by gene transfer as a prospective tool in cancer therapy.
Kleibl K; Margison GP
Neoplasma; 1998; 45(4):181-6. PubMed ID: 9890659
[TBL] [Abstract][Full Text] [Related]
16. DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability.
Rasimas JJ; Pegg AE; Fried MG
J Biol Chem; 2003 Mar; 278(10):7973-80. PubMed ID: 12496275
[TBL] [Abstract][Full Text] [Related]
17. Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase.
Rasimas JJ; Dalessio PA; Ropson IJ; Pegg AE; Fried MG
Protein Sci; 2004 Jan; 13(1):301-5. PubMed ID: 14691244
[TBL] [Abstract][Full Text] [Related]
18. O6-alkylguanine-DNA alkyltransferase activity in schistosomiasis-associated human bladder cancer.
Badawi AF; Cooper DP; Mostafa MH; Aboul-Azm T; Barnard R; Margison GP; O'Connor PJ
Eur J Cancer; 1994; 30A(9):1314-9. PubMed ID: 7999420
[TBL] [Abstract][Full Text] [Related]
19. Alkyltransferase-like proteins: molecular switches between DNA repair pathways.
Tubbs JL; Tainer JA
Cell Mol Life Sci; 2010 Nov; 67(22):3749-62. PubMed ID: 20502938
[TBL] [Abstract][Full Text] [Related]
20. Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli.
Potter PM; Wilkinson MC; Fitton J; Carr FJ; Brennand J; Cooper DP; Margison GP
Nucleic Acids Res; 1987 Nov; 15(22):9177-93. PubMed ID: 2825131
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]