BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

287 related articles for article (PubMed ID: 12731862)

  • 1. Functional and structural consequences of cysteine substitutions in the NH2 proximal region of the human multidrug resistance protein 1 (MRP1/ABCC1).
    Leslie EM; Létourneau IJ; Deeley RG; Cole SP
    Biochemistry; 2003 May; 42(18):5214-24. PubMed ID: 12731862
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Multiple membrane-associated tryptophan residues contribute to the transport activity and substrate specificity of the human multidrug resistance protein, MRP1.
    Koike K; Oleschuk CJ; Haimeur A; Olsen SL; Deeley RG; Cole SP
    J Biol Chem; 2002 Dec; 277(51):49495-503. PubMed ID: 12388549
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mutation of proline residues in the NH(2)-terminal region of the multidrug resistance protein, MRP1 (ABCC1): effects on protein expression, membrane localization, and transport function.
    Ito K; Weigl KE; Deeley RG; Cole SP
    Biochim Biophys Acta; 2003 Sep; 1615(1-2):103-14. PubMed ID: 12948592
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport.
    Ito K; Olsen SL; Qiu W; Deeley RG; Cole SP
    J Biol Chem; 2001 May; 276(19):15616-24. PubMed ID: 11278867
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions.
    Koike K; Conseil G; Leslie EM; Deeley RG; Cole SP
    J Biol Chem; 2004 Mar; 279(13):12325-36. PubMed ID: 14722114
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutations of charged amino acids in or near the transmembrane helices of the second membrane spanning domain differentially affect the substrate specificity and transport activity of the multidrug resistance protein MRP1 (ABCC1).
    Haimeur A; Conseil G; Deeley RG; Cole SP
    Mol Pharmacol; 2004 Jun; 65(6):1375-85. PubMed ID: 15155831
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3).
    Grant CE; Gao M; DeGorter MK; Cole SP; Deeley RG
    Drug Metab Dispos; 2008 Dec; 36(12):2571-81. PubMed ID: 18775981
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance.
    Conrad S; Kauffmann HM; Ito K; Leslie EM; Deeley RG; Schrenk D; Cole SP
    Pharmacogenetics; 2002 Jun; 12(4):321-30. PubMed ID: 12042670
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mutational analysis of polar amino acid residues within predicted transmembrane helices 10 and 16 of multidrug resistance protein 1 (ABCC1): effect on substrate specificity.
    Zhang DW; Nunoya K; Vasa M; Gu HM; Cole SP; Deeley RG
    Drug Metab Dispos; 2006 Apr; 34(4):539-46. PubMed ID: 16415113
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1.
    Yang Y; Chen Q; Zhang JT
    J Biol Chem; 2002 Nov; 277(46):44268-77. PubMed ID: 12235150
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required.
    Leslie EM; Haimeur A; Waalkes MP
    J Biol Chem; 2004 Jul; 279(31):32700-8. PubMed ID: 15161912
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization of binding of leukotriene C4 by human multidrug resistance protein 1: evidence of differential interactions with NH2- and COOH-proximal halves of the protein.
    Qian YM; Qiu W; Gao M; Westlake CJ; Cole SP; Deeley RG
    J Biol Chem; 2001 Oct; 276(42):38636-44. PubMed ID: 11507101
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function.
    Létourneau IJ; Slot AJ; Deeley RG; Cole SP
    Drug Metab Dispos; 2007 Aug; 35(8):1372-9. PubMed ID: 17494643
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Differential functional rescue of Lys(513) and Lys(516) processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter.
    Iram SH; Cole SP
    Biochim Biophys Acta; 2014 Mar; 1838(3):756-65. PubMed ID: 24231430
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conserved amino acids in the region connecting membrane spanning domain 1 to nucleotide binding domain 1 are essential for expression of the MRP1 (ABCC1) transporter.
    Smith EE; Conseil G; Cole SPC
    PLoS One; 2021; 16(2):e0246727. PubMed ID: 33571281
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1.
    Zhang DW; Nunoya K; Vasa M; Gu HM; Theis A; Cole SP; Deeley RG
    Biochemistry; 2004 Jul; 43(29):9413-25. PubMed ID: 15260484
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter.
    Létourneau IJ; Nakajima A; Deeley RG; Cole SP
    Biochem Pharmacol; 2008 Apr; 75(8):1659-69. PubMed ID: 18336795
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter.
    Situ D; Haimeur A; Conseil G; Sparks KE; Zhang D; Deeley RG; Cole SP
    J Biol Chem; 2004 Sep; 279(37):38871-80. PubMed ID: 15208328
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of the structural and functional boundaries of the multidrug resistance protein 1 cytoplasmic loop 3.
    Westlake CJ; Qian YM; Gao M; Vasa M; Cole SP; Deeley RG
    Biochemistry; 2003 Dec; 42(48):14099-113. PubMed ID: 14640677
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Two polymorphic variants of ABCC1 selectively alter drug resistance and inhibitor sensitivity of the multidrug and organic anion transporter multidrug resistance protein 1.
    Conseil G; Cole SP
    Drug Metab Dispos; 2013 Dec; 41(12):2187-96. PubMed ID: 24080162
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.