BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

160 related articles for article (PubMed ID: 12738359)

  • 1. Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis.
    Davis JE; Sutton VR; Browne KA; Trapani JA
    J Immunol Methods; 2003 May; 276(1-2):59-68. PubMed ID: 12738359
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Granule serine proteases are normal nuclear constituents of natural killer cells.
    Trapani JA; Smyth MJ; Apostolidis VA; Dawson M; Browne KA
    J Biol Chem; 1994 Jul; 269(28):18359-65. PubMed ID: 8034581
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Killing by cytotoxic T cells and natural killer cells: multiple granule serine proteases as initiators of DNA fragmentation.
    Trapani JA; Smyth MJ
    Immunol Cell Biol; 1993 Jun; 71 ( Pt 3)():201-8. PubMed ID: 8349302
    [TBL] [Abstract][Full Text] [Related]  

  • 4. In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells.
    Simon MM; Hausmann M; Tran T; Ebnet K; Tschopp J; ThaHla R; Müllbacher A
    J Exp Med; 1997 Nov; 186(10):1781-6. PubMed ID: 9362539
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Purification and use of granzyme B.
    Shi L; Yang X; Froelich CJ; Greenberg AH
    Methods Enzymol; 2000; 322():125-43. PubMed ID: 10914010
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2.
    Wei S; Gamero AM; Liu JH; Daulton AA; Valkov NI; Trapani JA; Larner AC; Weber MJ; Djeu JY
    J Exp Med; 1998 Jun; 187(11):1753-65. PubMed ID: 9607917
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Isolation and characterization of cytotoxic granules from human lymphokine (interleukin 2) activated killer cells.
    Lowrey DM; Hameed A; Lichtenheld M; Podack ER
    Cancer Res; 1988 Aug; 48(16):4681-8. PubMed ID: 3260817
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hypothesis: cytotoxic lymphocyte granule serine proteases activate target cell endonucleases to trigger apoptosis.
    Smyth MJ; Browne KA; Thia KY; Apostolidis VA; Kershaw MH; Trapani JA
    Clin Exp Pharmacol Physiol; 1994 Jan; 21(1):67-70. PubMed ID: 8156655
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway.
    Vermijlen D; Luo D; Froelich CJ; Medema JP; Kummer JA; Willems E; Braet F; Wisse E
    J Leukoc Biol; 2002 Oct; 72(4):668-76. PubMed ID: 12377935
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Fas-mediated cytotoxicity remains intact in perforin and granzyme B antisense transfectants of a human NK-like cell line.
    Montel AH; Bochan MR; Goebel WS; Brahmi Z
    Cell Immunol; 1995 Oct; 165(2):312-7. PubMed ID: 7553897
    [TBL] [Abstract][Full Text] [Related]  

  • 11. High activity of N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase and cytolytic perforin in cloned cell lines is not demonstrable in in-vivo-induced cytotoxic effector cells.
    Dennert G; Anderson CG; Prochazka G
    Proc Natl Acad Sci U S A; 1987 Jul; 84(14):5004-8. PubMed ID: 2955414
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal.
    Lieberman J
    Nat Rev Immunol; 2003 May; 3(5):361-70. PubMed ID: 12766758
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate.
    Veugelers K; Motyka B; Goping IS; Shostak I; Sawchuk T; Bleackley RC
    Mol Biol Cell; 2006 Feb; 17(2):623-33. PubMed ID: 16280358
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors.
    Kam CM; Hudig D; Powers JC
    Biochim Biophys Acta; 2000 Mar; 1477(1-2):307-23. PubMed ID: 10708866
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Human granzyme B is essential for DNA fragmentation of susceptible target cells.
    Su B; Bochan MR; Hanna WL; Froelich CJ; Brahmi Z
    Eur J Immunol; 1994 Sep; 24(9):2073-80. PubMed ID: 8088328
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sulfonyl fluoride serine protease inhibitors inactivate RNK-16 lymphocyte granule proteases and reduce lysis by granule extracts and perforin.
    Ewoldt GR; Winkler U; Powers JC; Hudig D
    Mol Immunol; 1992 Jun; 29(6):713-21. PubMed ID: 1603092
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo.
    Trapani JA; Davis J; Sutton VR; Smyth MJ
    Curr Opin Immunol; 2000 Jun; 12(3):323-9. PubMed ID: 10781403
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway.
    Isaaz S; Baetz K; Olsen K; Podack E; Griffiths GM
    Eur J Immunol; 1995 Apr; 25(4):1071-9. PubMed ID: 7737276
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.
    Metkar SS; Wang B; Aguilar-Santelises M; Raja SM; Uhlin-Hansen L; Podack E; Trapani JA; Froelich CJ
    Immunity; 2002 Mar; 16(3):417-28. PubMed ID: 11911826
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Characterization of a granule-independent lytic mechanism used by CTL hybridomas.
    Garner R; Helgason CD; Atkinson EA; Pinkoski MJ; Ostergaard HL; Sorensen O; Fu A; Lapchak PH; Rabinovitch A; McElhaney JE
    J Immunol; 1994 Dec; 153(12):5413-21. PubMed ID: 7527440
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.