BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

158 related articles for article (PubMed ID: 12740388)

  • 1. Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.
    Bohnsack RN; Haas AL
    J Biol Chem; 2003 Jul; 278(29):26823-30. PubMed ID: 12740388
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Expression, purification, and characterization of the E1 for human NEDD8, the heterodimeric APPBP1-UBA3 complex.
    Huang DT; Schulman BA
    Methods Enzymol; 2005; 398():9-20. PubMed ID: 16275315
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
    Walden H; Podgorski MS; Huang DT; Miller DW; Howard RJ; Minor DL; Holton JM; Schulman BA
    Mol Cell; 2003 Dec; 12(6):1427-37. PubMed ID: 14690597
    [TBL] [Abstract][Full Text] [Related]  

  • 4. E1-E2 interactions in ubiquitin and Nedd8 ligation pathways.
    Tokgöz Z; Siepmann TJ; Streich F; Kumar B; Klein JM; Haas AL
    J Biol Chem; 2012 Jan; 287(1):311-321. PubMed ID: 22069333
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.
    Souphron J; Waddell MB; Paydar A; Tokgöz-Gromley Z; Roussel MF; Schulman BA
    Biochemistry; 2008 Aug; 47(34):8961-9. PubMed ID: 18652489
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The activating enzyme of NEDD8 inhibits steroid receptor function.
    Fan M; Long X; Bailey JA; Reed CA; Osborne E; Gize EA; Kirk EA; Bigsby RM; Nephew KP
    Mol Endocrinol; 2002 Feb; 16(2):315-30. PubMed ID: 11818503
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dissecting Distinct Roles of NEDDylation E1 Ligase Heterodimer APPBP1 and UBA3 Reveals Potential Evolution Process for Activation of Ubiquitin-related Pathways.
    Malik-Chaudhry HK; Gaieb Z; Saavedra A; Reyes M; Kung R; Le F; Morikis D; Liao J
    Sci Rep; 2018 Jul; 8(1):10108. PubMed ID: 29973603
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.
    Walden H; Podgorski MS; Schulman BA
    Nature; 2003 Mar; 422(6929):330-4. PubMed ID: 12646924
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway.
    Gong L; Yeh ET
    J Biol Chem; 1999 Apr; 274(17):12036-42. PubMed ID: 10207026
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization.
    Wu K; Chen A; Pan ZQ
    J Biol Chem; 2000 Oct; 275(41):32317-24. PubMed ID: 10921923
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A metal-based inhibitor of NEDD8-activating enzyme.
    Zhong HJ; Yang H; Chan DS; Leung CH; Wang HM; Ma DL
    PLoS One; 2012; 7(11):e49574. PubMed ID: 23185368
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification and application of NEDD8 E1 inhibitors.
    Bruzzese FJ; Milhollen MA; Gavin JM; Josephine HR; Brownell JE
    Methods Mol Biol; 2012; 832():577-88. PubMed ID: 22350913
    [TBL] [Abstract][Full Text] [Related]  

  • 13. E2-binding surface on Uba3 β-grasp domain undergoes a conformational transition.
    Elgin ES; Sökmen N; Peterson FC; Volkman BF; Dağ C; Haas AL
    Proteins; 2012 Oct; 80(10):2482-7. PubMed ID: 22821745
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.
    Huang DT; Miller DW; Mathew R; Cassell R; Holton JM; Roussel MF; Schulman BA
    Nat Struct Mol Biol; 2004 Oct; 11(10):927-35. PubMed ID: 15361859
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Neddylation dysfunction in Alzheimer's disease.
    Chen Y; Neve RL; Liu H
    J Cell Mol Med; 2012 Nov; 16(11):2583-91. PubMed ID: 22805479
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of the NEDD8 conjugation pathway by shRNA to UBA3, the subunit of the NEDD8-activating enzyme, suppresses the growth of melanoma cells.
    Cheng F; Chen H; Zhang L; Li RH; Liu Y; Sun JF
    Asian Pac J Cancer Prev; 2012; 13(1):57-62. PubMed ID: 22502714
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.
    Huang DT; Hunt HW; Zhuang M; Ohi MD; Holton JM; Schulman BA
    Nature; 2007 Jan; 445(7126):394-8. PubMed ID: 17220875
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.
    Huang DT; Paydar A; Zhuang M; Waddell MB; Holton JM; Schulman BA
    Mol Cell; 2005 Feb; 17(3):341-50. PubMed ID: 15694336
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes.
    Whitby FG; Xia G; Pickart CM; Hill CP
    J Biol Chem; 1998 Dec; 273(52):34983-91. PubMed ID: 9857030
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells.
    Fan M; Bigsby RM; Nephew KP
    Mol Endocrinol; 2003 Mar; 17(3):356-65. PubMed ID: 12554766
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.