BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

119 related articles for article (PubMed ID: 12746450)

  • 1. Mutations in the met oncogene unveil a "dual switch" mechanism controlling tyrosine kinase activity.
    Chiara F; Michieli P; Pugliese L; Comoglio PM
    J Biol Chem; 2003 Aug; 278(31):29352-8. PubMed ID: 12746450
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).
    Longati P; Bardelli A; Ponzetto C; Naldini L; Comoglio PM
    Oncogene; 1994 Jan; 9(1):49-57. PubMed ID: 8302603
    [TBL] [Abstract][Full Text] [Related]  

  • 3. MET(PRC) mutations in the Ron receptor result in upregulation of tyrosine kinase activity and acquisition of oncogenic potential.
    Williams TA; Longati P; Pugliese L; Gual P; Bardelli A; Michieli P
    J Cell Physiol; 1999 Dec; 181(3):507-14. PubMed ID: 10528237
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Regulation of the wild-type and Y1235D mutant Met kinase activation.
    Cristiani C; Rusconi L; Perego R; Schiering N; Kalisz HM; Knapp S; Isacchi A
    Biochemistry; 2005 Nov; 44(43):14110-9. PubMed ID: 16245927
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Deletion of the ectodomain unleashes the transforming, invasive, and tumorigenic potential of the MET oncogene.
    Merlin S; Pietronave S; Locarno D; Valente G; Follenzi A; Prat M
    Cancer Sci; 2009 Apr; 100(4):633-8. PubMed ID: 19175607
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Activating mutations for the met tyrosine kinase receptor in human cancer.
    Jeffers M; Schmidt L; Nakaigawa N; Webb CP; Weirich G; Kishida T; Zbar B; Vande Woude GF
    Proc Natl Acad Sci U S A; 1997 Oct; 94(21):11445-50. PubMed ID: 9326629
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation.
    Peschard P; Ishiyama N; Lin T; Lipkowitz S; Park M
    J Biol Chem; 2004 Jul; 279(28):29565-71. PubMed ID: 15123609
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase.
    Rodrigues GA; Park M
    Oncogene; 1994 Jul; 9(7):2019-27. PubMed ID: 8208547
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel mutations of the MET proto-oncogene in papillary renal carcinomas.
    Schmidt L; Junker K; Nakaigawa N; Kinjerski T; Weirich G; Miller M; Lubensky I; Neumann HP; Brauch H; Decker J; Vocke C; Brown JA; Jenkins R; Richard S; Bergerheim U; Gerrard B; Dean M; Linehan WM; Zbar B
    Oncogene; 1999 Apr; 18(14):2343-50. PubMed ID: 10327054
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cross-talk between the proto-oncogenes Met and Ron.
    Follenzi A; Bakovic S; Gual P; Stella MC; Longati P; Comoglio PM
    Oncogene; 2000 Jun; 19(27):3041-9. PubMed ID: 10871856
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth.
    Bardelli A; Longati P; Gramaglia D; Basilico C; Tamagnone L; Giordano S; Ballinari D; Michieli P; Comoglio PM
    Proc Natl Acad Sci U S A; 1998 Nov; 95(24):14379-83. PubMed ID: 9826708
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells.
    Comoglio PM
    EXS; 1993; 65():131-65. PubMed ID: 8380735
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors.
    Timofeevski SL; McTigue MA; Ryan K; Cui J; Zou HY; Zhu JX; Chau F; Alton G; Karlicek S; Christensen JG; Murray BW
    Biochemistry; 2009 Jun; 48(23):5339-49. PubMed ID: 19459657
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists.
    Michieli P; Basilico C; Pennacchietti S; Maffè A; Tamagnone L; Giordano S; Bardelli A; Comoglio PM
    Oncogene; 1999 Sep; 18(37):5221-31. PubMed ID: 10498872
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Activating mutations in the Met receptor overcome the requirement for autophosphorylation of tyrosines crucial for wild type signaling.
    Jeffers MF; Vande Woude GF
    Oncogene; 1999 Sep; 18(36):5120-5. PubMed ID: 10490849
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: modeling studies.
    Miller M; Ginalski K; Lesyng B; Nakaigawa N; Schmidt L; Zbar B
    Proteins; 2001 Jul; 44(1):32-43. PubMed ID: 11354004
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein.
    Lamorte L; Kamikura DM; Park M
    Oncogene; 2000 Dec; 19(52):5973-81. PubMed ID: 11146548
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation.
    Xie S; Wang Y; Liu J; Sun T; Wilson MB; Smithgall TE; Arlinghaus RB
    Oncogene; 2001 Sep; 20(43):6188-95. PubMed ID: 11593427
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase.
    Rodrigues GA; Park M
    Mol Cell Biol; 1993 Nov; 13(11):6711-22. PubMed ID: 8413267
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor.
    Jeffers M; Koochekpour S; Fiscella M; Sathyanarayana BK; Vande Woude GF
    Oncogene; 1998 Nov; 17(21):2691-700. PubMed ID: 9840933
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.