These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

219 related articles for article (PubMed ID: 12747794)

  • 1. Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.
    Chambers MS; Atack JR; Broughton HB; Collinson N; Cook S; Dawson GR; Hobbs SC; Marshall G; Maubach KA; Pillai GV; Reeve AJ; MacLeod AM
    J Med Chem; 2003 May; 46(11):2227-40. PubMed ID: 12747794
    [TBL] [Abstract][Full Text] [Related]  

  • 2. L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors.
    Atack JR; Bayley PJ; Seabrook GR; Wafford KA; McKernan RM; Dawson GR
    Neuropharmacology; 2006 Nov; 51(6):1023-9. PubMed ID: 17046030
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.
    Street LJ; Sternfeld F; Jelley RA; Reeve AJ; Carling RW; Moore KW; McKernan RM; Sohal B; Cook S; Pike A; Dawson GR; Bromidge FA; Wafford KA; Seabrook GR; Thompson SA; Marshall G; Pillai GV; Castro JL; Atack JR; MacLeod AM
    J Med Chem; 2004 Jul; 47(14):3642-57. PubMed ID: 15214791
    [TBL] [Abstract][Full Text] [Related]  

  • 4. An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.
    Chambers MS; Atack JR; Carling RW; Collinson N; Cook SM; Dawson GR; Ferris P; Hobbs SC; O'connor D; Marshall G; Rycroft W; Macleod AM
    J Med Chem; 2004 Nov; 47(24):5829-32. PubMed ID: 15537339
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists.
    Chambers MS; Atack JR; Bromidge FA; Broughton HB; Cook S; Dawson GR; Hobbs SC; Maubach KA; Reeve AJ; Seabrook GR; Wafford K; MacLeod AM
    J Med Chem; 2002 Mar; 45(6):1176-9. PubMed ID: 11881985
    [TBL] [Abstract][Full Text] [Related]  

  • 6. GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement.
    Atack JR
    Curr Top Med Chem; 2011; 11(9):1203-14. PubMed ID: 21050171
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Preclinical and clinical pharmacology of the GABAA receptor alpha5 subtype-selective inverse agonist alpha5IA.
    Atack JR
    Pharmacol Ther; 2010 Jan; 125(1):11-26. PubMed ID: 19770002
    [TBL] [Abstract][Full Text] [Related]  

  • 8. GABA(A) receptor subtype selective cognition enhancers.
    Maubach K
    Curr Drug Targets CNS Neurol Disord; 2003 Aug; 2(4):233-9. PubMed ID: 12871033
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The proconvulsant effects of the GABAA alpha5 subtype-selective compound RY-080 may not be alpha5-mediated.
    Atack JR; Bayley PJ; Fletcher SR; McKernan RM; Wafford KA; Dawson GR
    Eur J Pharmacol; 2006 Oct; 548(1-3):77-82. PubMed ID: 16962577
    [TBL] [Abstract][Full Text] [Related]  

  • 10. RO4938581, a novel cognitive enhancer acting at GABAA alpha5 subunit-containing receptors.
    Ballard TM; Knoflach F; Prinssen E; Borroni E; Vivian JA; Basile J; Gasser R; Moreau JL; Wettstein JG; Buettelmann B; Knust H; Thomas AW; Trube G; Hernandez MC
    Psychopharmacology (Berl); 2009 Jan; 202(1-3):207-23. PubMed ID: 18936916
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 3,4-Dihydronaphthalen-1(2H)-ones: novel ligands for the benzodiazepine site of alpha5-containing GABAA receptors.
    Szekeres HJ; Atack JR; Chambers MS; Cook SM; Macaulay AJ; Pillai GV; MacLeod AM
    Bioorg Med Chem Lett; 2004 Jun; 14(11):2871-5. PubMed ID: 15125950
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.
    Atack JR; Maubach KA; Wafford KA; O'Connor D; Rodrigues AD; Evans DC; Tattersall FD; Chambers MS; MacLeod AM; Eng WS; Ryan C; Hostetler E; Sanabria SM; Gibson RE; Krause S; Burns HD; Hargreaves RJ; Agrawal NG; McKernan RM; Murphy MG; Gingrich K; Dawson GR; Musson DG; Petty KJ
    J Pharmacol Exp Ther; 2009 Nov; 331(2):470-84. PubMed ID: 19704033
    [TBL] [Abstract][Full Text] [Related]  

  • 13. An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition.
    Dawson GR; Maubach KA; Collinson N; Cobain M; Everitt BJ; MacLeod AM; Choudhury HI; McDonald LM; Pillai G; Rycroft W; Smith AJ; Sternfeld F; Tattersall FD; Wafford KA; Reynolds DS; Seabrook GR; Atack JR
    J Pharmacol Exp Ther; 2006 Mar; 316(3):1335-45. PubMed ID: 16326923
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 6,2'-Dihydroxyflavone, a subtype-selective partial inverse agonist of GABAA receptor benzodiazepine site.
    Wang F; Xu Z; Yuen CT; Chow CY; Lui YL; Tsang SY; Xue H
    Neuropharmacology; 2007 Sep; 53(4):574-82. PubMed ID: 17681556
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.
    Achermann G; Ballard TM; Blasco F; Broutin PE; Büttelmann B; Fischer H; Graf M; Hernandez MC; Hilty P; Knoflach F; Koblet A; Knust H; Kurt A; Martin JR; Masciadri R; Porter RH; Stadler H; Thomas AW; Trube G; Wichmann J
    Bioorg Med Chem Lett; 2009 Oct; 19(19):5746-52. PubMed ID: 19726184
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
    Madsen C; Jensen AA; Liljefors T; Kristiansen U; Nielsen B; Hansen CP; Larsen M; Ebert B; Bang-Andersen B; Krogsgaard-Larsen P; Frølund B
    J Med Chem; 2007 Aug; 50(17):4147-61. PubMed ID: 17655213
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage.
    Guerrini G; Ciciani G; Cambi G; Bruni F; Selleri S; Besnard F; Montali M; Martini C; Ghelardini C; Galeotti N; Costanzo A
    Bioorg Med Chem; 2007 Apr; 15(7):2573-86. PubMed ID: 17306981
    [TBL] [Abstract][Full Text] [Related]  

  • 18. γ-Aminobutyric acid type A (GABA(A)) receptor subtype inverse agonists as therapeutic agents in cognition.
    Gabriella G; Giovanna C
    Methods Enzymol; 2010; 485():197-211. PubMed ID: 21050918
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A new pyridazine series of GABAA alpha5 ligands.
    van Niel MB; Wilson K; Adkins CH; Atack JR; Castro JL; Clarke DE; Fletcher S; Gerhard U; Mackey MM; Malpas S; Maubach K; Newman R; O'Connor D; Pillai GV; Simpson PB; Thomas SR; MacLeod AM
    J Med Chem; 2005 Sep; 48(19):6004-11. PubMed ID: 16162003
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.
    Sternfeld F; Carling RW; Jelley RA; Ladduwahetty T; Merchant KJ; Moore KW; Reeve AJ; Street LJ; O'Connor D; Sohal B; Atack JR; Cook S; Seabrook G; Wafford K; Tattersall FD; Collinson N; Dawson GR; Castro JL; MacLeod AM
    J Med Chem; 2004 Apr; 47(9):2176-9. PubMed ID: 15084116
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.