BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

163 related articles for article (PubMed ID: 12747798)

  • 1. Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.
    Singh SK; Ruchelman AL; Li TK; Liu A; Liu LF; LaVoie EJ
    J Med Chem; 2003 May; 46(11):2254-7. PubMed ID: 12747798
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity.
    Ruchelman AL; Kerrigan JE; Li TK; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2004 Jul; 12(13):3731-42. PubMed ID: 15186859
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.
    Ruchelman AL; Zhu S; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5585-9. PubMed ID: 15482929
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.
    Ruchelman AL; Houghton PJ; Zhou N; Liu A; Liu LF; LaVoie EJ
    J Med Chem; 2005 Feb; 48(3):792-804. PubMed ID: 15689163
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates.
    Feng W; Satyanarayana M; Tsai YC; Liu AA; Liu LF; Lavoie EJ
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3570-2. PubMed ID: 18511275
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity.
    Ruchelman AL; Singh SK; Ray A; Wu X; Yang JM; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2004 Feb; 12(4):795-806. PubMed ID: 14759740
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents.
    Feng W; Satyanarayana M; Cheng L; Liu A; Tsai YC; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2008 Oct; 16(20):9295-301. PubMed ID: 18829334
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity.
    Zhu S; Ruchelman AL; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2006 May; 14(9):3131-43. PubMed ID: 16412652
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
    Chen K; Kuo SC; Hsieh MC; Mauger A; Lin CM; Hamel E; Lee KH
    J Med Chem; 1997 Jul; 40(14):2266-75. PubMed ID: 9216846
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31).
    Satyanarayana M; Feng W; Cheng L; Liu AA; Tsai YC; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2008 Aug; 16(16):7824-31. PubMed ID: 18676151
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridin-(5H)ones.
    Deady LW; Rogers ML; Zhuang L; Baguley BC; Denny WA
    Bioorg Med Chem; 2005 Feb; 13(4):1341-55. PubMed ID: 15670942
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide.
    Feng W; Satyanarayana M; Tsai YC; Liu AA; Liu LF; LaVoie EJ
    Eur J Med Chem; 2009 Sep; 44(9):3433-8. PubMed ID: 19299037
    [TBL] [Abstract][Full Text] [Related]  

  • 13. cis-Dichloroplatinum(II) complexes tethered to dibenzo[c,h][1,6]naphthyridin-6-ones: synthesis and cytotoxicity in human cancer cell lines in vitro.
    Desbois N; Pertuit D; Moretto J; Cachia C; Chauffert B; Bouyer F
    Eur J Med Chem; 2013 Nov; 69():719-27. PubMed ID: 24095763
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity.
    Ruchelman AL; Singh SK; Ray A; Wu XH; Yang JM; Li TK; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2003 May; 11(9):2061-73. PubMed ID: 12670657
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.
    Chen K; Kuo SC; Hsieh MC; Mauger A; Lin CM; Hamel E; Lee KH
    J Med Chem; 1997 Sep; 40(19):3049-56. PubMed ID: 9301667
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.
    Kurtzberg LS; Roth S; Krumbholz R; Crawford J; Bormann C; Dunham S; Yao M; Rouleau C; Bagley RG; Yu XJ; Wang F; Schmid SM; Lavoie EJ; Teicher BA
    Clin Cancer Res; 2011 May; 17(9):2777-87. PubMed ID: 21415217
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
    Li TK; Houghton PJ; Desai SD; Daroui P; Liu AA; Hars ES; Ruchelman AL; LaVoie EJ; Liu LF
    Cancer Res; 2003 Dec; 63(23):8400-7. PubMed ID: 14679002
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons.
    Strumberg D; Pommier Y; Paull K; Jayaraman M; Nagafuji P; Cushman M
    J Med Chem; 1999 Feb; 42(3):446-57. PubMed ID: 9986716
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives.
    Ryckebusch A; Garcin D; Lansiaux A; Goossens JF; Baldeyrou B; Houssin R; Bailly C; Hénichart JP
    J Med Chem; 2008 Jun; 51(12):3617-29. PubMed ID: 18507368
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones.
    Sharma L; Tsai YC; Liu AA; Liu LF; LaVoie EJ
    Eur J Med Chem; 2009 Apr; 44(4):1471-6. PubMed ID: 19012996
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.