These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

255 related articles for article (PubMed ID: 12763021)

  • 21. BACE1: the beta-secretase enzyme in Alzheimer's disease.
    Vassar R
    J Mol Neurosci; 2004; 23(1-2):105-14. PubMed ID: 15126696
    [TBL] [Abstract][Full Text] [Related]  

  • 22. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
    Kimberly WT; Xia W; Rahmati T; Wolfe MS; Selkoe DJ
    J Biol Chem; 2000 Feb; 275(5):3173-8. PubMed ID: 10652302
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.
    Berezovska O; Ramdya P; Skoch J; Wolfe MS; Bacskai BJ; Hyman BT
    J Neurosci; 2003 Jun; 23(11):4560-6. PubMed ID: 12805296
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network.
    Siman R; Velji J
    J Neurochem; 2003 Mar; 84(5):1143-53. PubMed ID: 12603837
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.
    Hansson CA; Popescu BO; Laudon H; Cedazo-Minguez A; Popescu LM; Winblad B; Ankarcrona M
    J Neurochem; 2006 Apr; 97(2):356-64. PubMed ID: 16539675
    [TBL] [Abstract][Full Text] [Related]  

  • 26. gamma-Secretase inhibitors as molecular probes of presenilin function.
    Wolfe MS
    J Mol Neurosci; 2001 Oct; 17(2):199-204. PubMed ID: 11816793
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.
    Quintero-Monzon O; Martin MM; Fernandez MA; Cappello CA; Krzysiak AJ; Osenkowski P; Wolfe MS
    Biochemistry; 2011 Oct; 50(42):9023-35. PubMed ID: 21919498
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Presenilin 1 is required for maturation and cell surface accumulation of nicastrin.
    Leem JY; Vijayan S; Han P; Cai D; Machura M; Lopes KO; Veselits ML; Xu H; Thinakaran G
    J Biol Chem; 2002 May; 277(21):19236-40. PubMed ID: 11943765
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
    Jankowsky JL; Fadale DJ; Anderson J; Xu GM; Gonzales V; Jenkins NA; Copeland NG; Lee MK; Younkin LH; Wagner SL; Younkin SG; Borchelt DR
    Hum Mol Genet; 2004 Jan; 13(2):159-70. PubMed ID: 14645205
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
    Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
    J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Reconstitution of gamma-secretase activity.
    Edbauer D; Winkler E; Regula JT; Pesold B; Steiner H; Haass C
    Nat Cell Biol; 2003 May; 5(5):486-8. PubMed ID: 12679784
    [TBL] [Abstract][Full Text] [Related]  

  • 32. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
    Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; Nishimura M; Yanagisawa K; Komano H
    J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
    Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
    Ikeuchi T; Dolios G; Kim SH; Wang R; Sisodia SS
    J Biol Chem; 2003 Feb; 278(9):7010-8. PubMed ID: 12493731
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation.
    Sudoh S; Hua G; Kawamura Y; Maruyama K; Komano H; Yanagisawa K
    Eur J Biochem; 2000 Apr; 267(7):2036-45. PubMed ID: 10727943
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.
    Laudon H; Mathews PM; Karlström H; Bergman A; Farmery MR; Nixon RA; Winblad B; Gandy SE; Lendahl U; Lundkvist J; Näslund J
    J Neurochem; 2004 Apr; 89(1):44-53. PubMed ID: 15030388
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Identification of distinct gamma-secretase complexes with different APH-1 variants.
    Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H
    J Biol Chem; 2004 Oct; 279(40):41340-5. PubMed ID: 15286082
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
    Xia W; Ray WJ; Ostaszewski BL; Rahmati T; Kimberly WT; Wolfe MS; Zhang J; Goate AM; Selkoe DJ
    Proc Natl Acad Sci U S A; 2000 Aug; 97(16):9299-304. PubMed ID: 10922078
    [TBL] [Abstract][Full Text] [Related]  

  • 39. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
    Chen WT; Hsieh YF; Huang YJ; Lin CC; Lin YT; Liu YC; Lien CC; Cheng IH
    Mol Neurobiol; 2015 Dec; 52(3):1835-1849. PubMed ID: 25394380
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.
    Meckler X; Roseman J; Das P; Cheng H; Pei S; Keat M; Kassarjian B; Golde TE; Parent AT; Thinakaran G
    J Neurosci; 2010 Dec; 30(48):16160-9. PubMed ID: 21123562
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.