217 related articles for article (PubMed ID: 12771124)
1. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex.
Hu Y; Fortini ME
J Cell Biol; 2003 May; 161(4):685-90. PubMed ID: 12771124
[TBL] [Abstract][Full Text] [Related]
2. The role of presenilin cofactors in the gamma-secretase complex.
Takasugi N; Tomita T; Hayashi I; Tsuruoka M; Niimura M; Takahashi Y; Thinakaran G; Iwatsubo T
Nature; 2003 Mar; 422(6930):438-41. PubMed ID: 12660785
[TBL] [Abstract][Full Text] [Related]
3. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Francis R; McGrath G; Zhang J; Ruddy DA; Sym M; Apfeld J; Nicoll M; Maxwell M; Hai B; Ellis MC; Parks AL; Xu W; Li J; Gurney M; Myers RL; Himes CS; Hiebsch R; Ruble C; Nye JS; Curtis D
Dev Cell; 2002 Jul; 3(1):85-97. PubMed ID: 12110170
[TBL] [Abstract][Full Text] [Related]
4. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
Kimberly WT; LaVoie MJ; Ostaszewski BL; Ye W; Wolfe MS; Selkoe DJ
Proc Natl Acad Sci U S A; 2003 May; 100(11):6382-7. PubMed ID: 12740439
[TBL] [Abstract][Full Text] [Related]
5. A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex.
Lee SF; Shah S; Yu C; Wigley WC; Li H; Lim M; Pedersen K; Han W; Thomas P; Lundkvist J; Hao YH; Yu G
J Biol Chem; 2004 Feb; 279(6):4144-52. PubMed ID: 14627705
[TBL] [Abstract][Full Text] [Related]
6. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.
Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui-Tei K; Saigo K; Morohashi Y; Tomita T; Iwatsubo T
J Biol Chem; 2005 Apr; 280(13):12967-75. PubMed ID: 15644323
[TBL] [Abstract][Full Text] [Related]
7. Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment.
Mao G; Cui MZ; Li T; Jin Y; Xu X
J Neurochem; 2012 Dec; 123(5):837-44. PubMed ID: 22973949
[TBL] [Abstract][Full Text] [Related]
8. The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex.
Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; Lee VM; Doms RW
J Biol Chem; 2003 Oct; 278(44):43284-91. PubMed ID: 12917438
[TBL] [Abstract][Full Text] [Related]
9. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; Liao F; Li F; Wong PC; Farquhar MG; Thinakaran G; Xu H
J Biol Chem; 2005 Apr; 280(17):17020-6. PubMed ID: 15711015
[TBL] [Abstract][Full Text] [Related]
10. Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization.
Kopan R; Goate A
Neuron; 2002 Jan; 33(3):321-4. PubMed ID: 11832221
[TBL] [Abstract][Full Text] [Related]
11. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
Li T; Ma G; Cai H; Price DL; Wong PC
J Neurosci; 2003 Apr; 23(8):3272-7. PubMed ID: 12716934
[TBL] [Abstract][Full Text] [Related]
12. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
[TBL] [Abstract][Full Text] [Related]
13. Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch.
Hansson EM; Strömberg K; Bergstedt S; Yu G; Näslund J; Lundkvist J; Lendahl U
J Neurochem; 2005 Mar; 92(5):1010-20. PubMed ID: 15715652
[TBL] [Abstract][Full Text] [Related]
14. The gamma-secretase complex: machinery for intramembrane proteolysis.
Iwatsubo T
Curr Opin Neurobiol; 2004 Jun; 14(3):379-83. PubMed ID: 15194119
[TBL] [Abstract][Full Text] [Related]
15. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.
Hu Y; Ye Y; Fortini ME
Dev Cell; 2002 Jan; 2(1):69-78. PubMed ID: 11782315
[TBL] [Abstract][Full Text] [Related]
16. Aph-1 is required to regulate Presenilin-mediated gamma-secretase activity and cell survival in Drosophila wing development.
Cooper E; Deng WM; Chung HM
Genesis; 2009 Mar; 47(3):169-74. PubMed ID: 19191330
[TBL] [Abstract][Full Text] [Related]
17. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.
LaVoie MJ; Fraering PC; Ostaszewski BL; Ye W; Kimberly WT; Wolfe MS; Selkoe DJ
J Biol Chem; 2003 Sep; 278(39):37213-22. PubMed ID: 12857757
[TBL] [Abstract][Full Text] [Related]
18. Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Periz G; Fortini ME
J Neurosci Res; 2004 Aug; 77(3):309-22. PubMed ID: 15248287
[TBL] [Abstract][Full Text] [Related]
19. Gamma-secretase complex assembly within the early secretory pathway.
Capell A; Beher D; Prokop S; Steiner H; Kaether C; Shearman MS; Haass C
J Biol Chem; 2005 Feb; 280(8):6471-8. PubMed ID: 15591316
[TBL] [Abstract][Full Text] [Related]
20. gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo.
Doglio LE; Kanwar R; Jackson GR; Perez M; Avila J; Dingwall C; Dotti CG; Fortini ME; Feiguin F
Neuron; 2006 May; 50(3):359-75. PubMed ID: 16675392
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
