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2. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Tee AR; Fingar DC; Manning BD; Kwiatkowski DJ; Cantley LC; Blenis J Proc Natl Acad Sci U S A; 2002 Oct; 99(21):13571-6. PubMed ID: 12271141 [TBL] [Abstract][Full Text] [Related]
3. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Tee AR; Manning BD; Roux PP; Cantley LC; Blenis J Curr Biol; 2003 Aug; 13(15):1259-68. PubMed ID: 12906785 [TBL] [Abstract][Full Text] [Related]
4. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Roux PP; Ballif BA; Anjum R; Gygi SP; Blenis J Proc Natl Acad Sci U S A; 2004 Sep; 101(37):13489-94. PubMed ID: 15342917 [TBL] [Abstract][Full Text] [Related]
5. Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. Tee AR; Anjum R; Blenis J J Biol Chem; 2003 Sep; 278(39):37288-96. PubMed ID: 12867426 [TBL] [Abstract][Full Text] [Related]
6. Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. Dan HC; Sun M; Yang L; Feldman RI; Sui XM; Ou CC; Nellist M; Yeung RS; Halley DJ; Nicosia SV; Pledger WJ; Cheng JQ J Biol Chem; 2002 Sep; 277(38):35364-70. PubMed ID: 12167664 [TBL] [Abstract][Full Text] [Related]
7. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Inoki K; Li Y; Zhu T; Wu J; Guan KL Nat Cell Biol; 2002 Sep; 4(9):648-57. PubMed ID: 12172553 [TBL] [Abstract][Full Text] [Related]
8. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. Jaeschke A; Hartkamp J; Saitoh M; Roworth W; Nobukuni T; Hodges A; Sampson J; Thomas G; Lamb R J Cell Biol; 2002 Oct; 159(2):217-24. PubMed ID: 12403809 [TBL] [Abstract][Full Text] [Related]
9. Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy. Valianou M; Cox AM; Pichette B; Hartley S; Paladhi UR; Astrinidis A Cell Cycle; 2015; 14(3):399-407. PubMed ID: 25565629 [TBL] [Abstract][Full Text] [Related]
10. Regulation of tuberous sclerosis complex (TSC) function by 14-3-3 proteins. Nellist M; Goedbloed MA; Halley DJ Biochem Soc Trans; 2003 Jun; 31(Pt 3):587-91. PubMed ID: 12773161 [TBL] [Abstract][Full Text] [Related]
11. TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex. Nellist M; Verhaaf B; Goedbloed MA; Reuser AJ; van den Ouweland AM; Halley DJ Hum Mol Genet; 2001 Dec; 10(25):2889-98. PubMed ID: 11741832 [TBL] [Abstract][Full Text] [Related]
12. The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb. Nobukini T; Thomas G Novartis Found Symp; 2004; 262():148-54; discussion 154-9, 265-8. PubMed ID: 15562827 [TBL] [Abstract][Full Text] [Related]
13. Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin. Hodges AK; Li S; Maynard J; Parry L; Braverman R; Cheadle JP; DeClue JE; Sampson JR Hum Mol Genet; 2001 Dec; 10(25):2899-905. PubMed ID: 11741833 [TBL] [Abstract][Full Text] [Related]
14. Evidence for separable functions of tuberous sclerosis gene products in mammalian cell cycle regulation. Miloloza A; Kubista M; Rosner M; Hengstschläger M J Neuropathol Exp Neurol; 2002 Feb; 61(2):154-63. PubMed ID: 11853018 [TBL] [Abstract][Full Text] [Related]
15. Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. Chan JA; Zhang H; Roberts PS; Jozwiak S; Wieslawa G; Lewin-Kowalik J; Kotulska K; Kwiatkowski DJ J Neuropathol Exp Neurol; 2004 Dec; 63(12):1236-42. PubMed ID: 15624760 [TBL] [Abstract][Full Text] [Related]
16. Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis. Aicher LD; Campbell JS; Yeung RS J Biol Chem; 2001 Jun; 276(24):21017-21. PubMed ID: 11290735 [TBL] [Abstract][Full Text] [Related]
18. Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. van Slegtenhorst M; Nellist M; Nagelkerken B; Cheadle J; Snell R; van den Ouweland A; Reuser A; Sampson J; Halley D; van der Sluijs P Hum Mol Genet; 1998 Jun; 7(6):1053-7. PubMed ID: 9580671 [TBL] [Abstract][Full Text] [Related]
19. Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: the role of promoter methylation of TSC genes. Jiang WG; Sampson J; Martin TA; Lee-Jones L; Watkins G; Douglas-Jones A; Mokbel K; Mansel RE Eur J Cancer; 2005 Jul; 41(11):1628-36. PubMed ID: 15951164 [TBL] [Abstract][Full Text] [Related]
20. Loss of expression of tuberin and hamartin in tuberous sclerosis complex-associated but not in sporadic angiofibromas. Fackler I; DeClue JE; Rust H; Vu PA; Kutzner H; Rütten A; Kaddu S; Sander CA; Volkenandt M; Johnson MW; Vinters HV; Wienecke R J Cutan Pathol; 2003 Mar; 30(3):174-7. PubMed ID: 12641776 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]