BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

308 related articles for article (PubMed ID: 12805296)

  • 1. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.
    Berezovska O; Ramdya P; Skoch J; Wolfe MS; Bacskai BJ; Hyman BT
    J Neurosci; 2003 Jun; 23(11):4560-6. PubMed ID: 12805296
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
    Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; Liao F; Li F; Wong PC; Farquhar MG; Thinakaran G; Xu H
    J Biol Chem; 2005 Apr; 280(17):17020-6. PubMed ID: 15711015
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
    J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
    [TBL] [Abstract][Full Text] [Related]  

  • 4. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
    Xia W; Ostaszewski BL; Kimberly WT; Rahmati T; Moore CL; Wolfe MS; Selkoe DJ
    Neurobiol Dis; 2000 Dec; 7(6 Pt B):673-81. PubMed ID: 11114265
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
    Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
    J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
    Li T; Ma G; Cai H; Price DL; Wong PC
    J Neurosci; 2003 Apr; 23(8):3272-7. PubMed ID: 12716934
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.
    Lleó A; Waldron E; von Arnim CA; Herl L; Tangredi MM; Peltan ID; Strickland DK; Koo EH; Hyman BT; Pietrzik CU; Berezovska O
    J Biol Chem; 2005 Jul; 280(29):27303-9. PubMed ID: 15917251
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
    Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
    J Biol Chem; 2004 Dec; 279(49):51654-60. PubMed ID: 15456764
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Activated Notch1 associates with a presenilin-1/gamma-secretase docking site.
    Ramdya P; Skoch J; Bacskai BJ; Hyman BT; Berezovska O
    J Neurochem; 2003 Nov; 87(4):843-50. PubMed ID: 14622115
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane.
    Pasternak SH; Bagshaw RD; Guiral M; Zhang S; Ackerley CA; Pak BJ; Callahan JW; Mahuran DJ
    J Biol Chem; 2003 Jul; 278(29):26687-94. PubMed ID: 12736250
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage.
    Chyung JH; Raper DM; Selkoe DJ
    J Biol Chem; 2005 Feb; 280(6):4383-92. PubMed ID: 15569674
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
    Rozmahel R; Mount HT; Chen F; Nguyen V; Huang J; Erdebil S; Liauw J; Yu G; Hasegawa H; Gu Y; Song YQ; Schmidt SD; Nixon RA; Mathews PM; Bergeron C; Fraser P; Westaway D; St George-Hyslop P
    Proc Natl Acad Sci U S A; 2002 Oct; 99(22):14452-7. PubMed ID: 12388777
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components.
    Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; Greengard P; Xu H
    J Biol Chem; 2004 Sep; 279(39):40560-6. PubMed ID: 15247291
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.
    Berezovska O; Lleo A; Herl LD; Frosch MP; Stern EA; Bacskai BJ; Hyman BT
    J Neurosci; 2005 Mar; 25(11):3009-17. PubMed ID: 15772361
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1.
    Liu Y; Zhang YW; Wang X; Zhang H; You X; Liao FF; Xu H
    J Biol Chem; 2009 May; 284(18):12145-52. PubMed ID: 19276086
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
    Xia W; Ray WJ; Ostaszewski BL; Rahmati T; Kimberly WT; Wolfe MS; Zhang J; Goate AM; Selkoe DJ
    Proc Natl Acad Sci U S A; 2000 Aug; 97(16):9299-304. PubMed ID: 10922078
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface.
    Leem JY; Saura CA; Pietrzik C; Christianson J; Wanamaker C; King LT; Veselits ML; Tomita T; Gasparini L; Iwatsubo T; Xu H; Green WN; Koo EH; Thinakaran G
    Neurobiol Dis; 2002 Oct; 11(1):64-82. PubMed ID: 12460547
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity.
    Bergman A; Laudon H; Winblad B; Lundkvist J; Näslund J
    J Biol Chem; 2004 Oct; 279(44):45564-72. PubMed ID: 15322123
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
    Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
    Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.