275 related articles for article (PubMed ID: 12807362)
1. Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5.
Jalas JR; Hecht SS
Chem Res Toxicol; 2003 Jun; 16(6):782-93. PubMed ID: 12807362
[TBL] [Abstract][Full Text] [Related]
2. Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Jalas JR; McIntee EJ; Kenney PM; Upadhyaya P; Peterson LA; Hecht SS
Chem Res Toxicol; 2003 Jun; 16(6):794-806. PubMed ID: 12807363
[TBL] [Abstract][Full Text] [Related]
3. Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.
Jalas JR; Ding X; Murphy SE
Drug Metab Dispos; 2003 Oct; 31(10):1199-202. PubMed ID: 12975327
[TBL] [Abstract][Full Text] [Related]
4. Characterization of cytochrome P450 2A4 and 2A5-catalyzed 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism.
Felicia ND; Rekha GK; Murphy SE
Arch Biochem Biophys; 2000 Dec; 384(2):418-24. PubMed ID: 11368333
[TBL] [Abstract][Full Text] [Related]
5. Analysis of CYP2A contributions to metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human peripheral lung microsomes.
Brown PJ; Bedard LL; Reid KR; Petsikas D; Massey TE
Drug Metab Dispos; 2007 Nov; 35(11):2086-94. PubMed ID: 17717079
[TBL] [Abstract][Full Text] [Related]
6. Tumorigenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers and metabolites in the A/J mouse.
Upadhyaya P; Kenney PM; Hochalter JB; Wang M; Hecht SS
Carcinogenesis; 1999 Aug; 20(8):1577-82. PubMed ID: 10426810
[TBL] [Abstract][Full Text] [Related]
7. Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Upadhyaya P; Kalscheuer S; Hochalter JB; Villalta PW; Hecht SS
Chem Res Toxicol; 2008 Jul; 21(7):1468-76. PubMed ID: 18570389
[TBL] [Abstract][Full Text] [Related]
8. Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues.
Upadhyaya P; Carmella SG; Guengerich FP; Hecht SS
Carcinogenesis; 2000 Jun; 21(6):1233-8. PubMed ID: 10837015
[TBL] [Abstract][Full Text] [Related]
9. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by inducible and constitutive cytochrome P450 enzymes in rats.
Guo Z; Smith TJ; Thomas PE; Yang CS
Arch Biochem Biophys; 1992 Oct; 298(1):279-86. PubMed ID: 1524438
[TBL] [Abstract][Full Text] [Related]
10. Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
Miyazaki M; Yamazaki H; Takeuchi H; Saoo K; Yokohira M; Masumura K; Nohmi T; Funae Y; Imaida K; Kamataki T
Carcinogenesis; 2005 Nov; 26(11):1947-55. PubMed ID: 15958517
[TBL] [Abstract][Full Text] [Related]
11. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification.
Narayanapillai SC; von Weymarn LB; Carmella SG; Leitzman P; Paladino J; Upadhyaya P; Hecht SS; Murphy SE; Xing C
Drug Metab Dispos; 2016 Mar; 44(3):422-7. PubMed ID: 26744252
[TBL] [Abstract][Full Text] [Related]
12. Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.
Zhou X; D'Agostino J; Xie F; Ding X
J Pharmacol Exp Ther; 2012 Apr; 341(1):233-41. PubMed ID: 22262919
[TBL] [Abstract][Full Text] [Related]
13. Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in lung tissue from mouse, rat, hamster, and man.
Richter E; Engl J; Friesenegger S; Tricker AR
Chem Res Toxicol; 2009 Jun; 22(6):1008-17. PubMed ID: 19408892
[TBL] [Abstract][Full Text] [Related]
14. Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Zhang S; Wang M; Villalta PW; Lindgren BR; Upadhyaya P; Lao Y; Hecht SS
Chem Res Toxicol; 2009 May; 22(5):926-36. PubMed ID: 19358518
[TBL] [Abstract][Full Text] [Related]
15. Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes.
Smith TJ; Liao AM; Liu Y; Jones AB; Anderson LM; Yang CS
Carcinogenesis; 1997 Aug; 18(8):1577-84. PubMed ID: 9276633
[TBL] [Abstract][Full Text] [Related]
16. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes and its inhibition by isothiocyanates.
Smith TJ; Guo ZY; Thomas PE; Chung FL; Morse MA; Elkind K; Yang CS
Cancer Res; 1990 Nov; 50(21):6817-22. PubMed ID: 2208146
[TBL] [Abstract][Full Text] [Related]
17. Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes.
Staretz ME; Murphy SE; Patten CJ; Nunes MG; Koehl W; Amin S; Koenig LA; Guengerich FP; Hecht SS
Drug Metab Dispos; 1997 Feb; 25(2):154-62. PubMed ID: 9029045
[TBL] [Abstract][Full Text] [Related]
18. Enantioselectivity of carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by tissue fractions from human and rat and by enzymes isolated from human liver.
Breyer-Pfaff U; Martin HJ; Ernst M; Maser E
Drug Metab Dispos; 2004 Sep; 32(9):915-22. PubMed ID: 15319331
[TBL] [Abstract][Full Text] [Related]
19. 11Beta-hydroxysteroid dehydrogenase responsible for carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes.
Maser E
Cancer Res; 1998 Jul; 58(14):2996-3003. PubMed ID: 9679962
[TBL] [Abstract][Full Text] [Related]
20. Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
Lao Y; Yu N; Kassie F; Villalta PW; Hecht SS
Chem Res Toxicol; 2007 Feb; 20(2):235-45. PubMed ID: 17305407
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
