BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

175 related articles for article (PubMed ID: 12808146)

  • 1. Direct activation of the apoptosis machinery as a mechanism to target cancer cells.
    Nguyen JT; Wells JA
    Proc Natl Acad Sci U S A; 2003 Jun; 100(13):7533-8. PubMed ID: 12808146
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity.
    Wolf BB; Schuler M; Li W; Eggers-Sedlet B; Lee W; Tailor P; Fitzgerald P; Mills GB; Green DR
    J Biol Chem; 2001 Sep; 276(36):34244-51. PubMed ID: 11429402
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90.
    Pandey P; Saleh A; Nakazawa A; Kumar S; Srinivasula SM; Kumar V; Weichselbaum R; Nalin C; Alnemri ES; Kufe D; Kharbanda S
    EMBO J; 2000 Aug; 19(16):4310-22. PubMed ID: 10944114
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Apaf-1 overexpression partially overcomes apoptotic resistance in a cisplatin-selected HeLa cell line.
    Kamarajan P; Sun NK; Sun CL; Chao CC
    FEBS Lett; 2001 Sep; 505(2):206-12. PubMed ID: 11566177
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis.
    Lauber K; Appel HA; Schlosser SF; Gregor M; Schulze-Osthoff K; Wesselborg S
    J Biol Chem; 2001 Aug; 276(32):29772-81. PubMed ID: 11387322
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells.
    Jia L; Srinivasula SM; Liu FT; Newland AC; Fernandes-Alnemri T; Alnemri ES; Kelsey SM
    Blood; 2001 Jul; 98(2):414-21. PubMed ID: 11435311
    [TBL] [Abstract][Full Text] [Related]  

  • 7. p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
    Mashima T; Oh-hara T; Sato S; Mochizuki M; Sugimoto Y; Yamazaki K; Hamada J; Tada M; Moriuchi T; Ishikawa Y; Kato Y; Tomoda H; Yamori T; Tsuruo T
    J Natl Cancer Inst; 2005 May; 97(10):765-77. PubMed ID: 15900046
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome.
    Beere HM; Wolf BB; Cain K; Mosser DD; Mahboubi A; Kuwana T; Tailor P; Morimoto RI; Cohen GM; Green DR
    Nat Cell Biol; 2000 Aug; 2(8):469-75. PubMed ID: 10934466
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Transforming growth factor-beta(1) induces apoptosis in rat FaO hepatoma cells via cytochrome c release and oligomerization of Apaf-1 to form a approximately 700-kd apoptosome caspase-processing complex.
    Freathy C; Brown DG; Roberts RA; Cain K
    Hepatology; 2000 Oct; 32(4 Pt 1):750-60. PubMed ID: 11003619
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex.
    Twiddy D; Brown DG; Adrain C; Jukes R; Martin SJ; Cohen GM; MacFarlane M; Cain K
    J Biol Chem; 2004 May; 279(19):19665-82. PubMed ID: 14993223
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Apoptosome-independent pathway for apoptosis. Biochemical analysis of APAF-1 defects and biological outcomes.
    Belmokhtar CA; Hillion J; Dudognon C; Fiorentino S; Flexor M; Lanotte M; Ségal-Bendirdjian E
    J Biol Chem; 2003 Aug; 278(32):29571-80. PubMed ID: 12773531
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway.
    Genini D; Budihardjo I; Plunkett W; Wang X; Carrera CJ; Cottam HB; Carson DA; Leoni LM
    J Biol Chem; 2000 Jan; 275(1):29-34. PubMed ID: 10617581
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Chemical-induced apoptosis: formation of the Apaf-1 apoptosome.
    Cain K
    Drug Metab Rev; 2003 Nov; 35(4):337-63. PubMed ID: 14705865
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.
    Yang L; Mashima T; Sato S; Mochizuki M; Sakamoto H; Yamori T; Oh-Hara T; Tsuruo T
    Cancer Res; 2003 Feb; 63(4):831-7. PubMed ID: 12591734
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis.
    Martin AG; Fearnhead HO
    J Biol Chem; 2002 Dec; 277(52):50834-41. PubMed ID: 12393884
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome C.
    Murphy BM; O'Neill AJ; Adrain C; Watson RW; Martin SJ
    J Exp Med; 2003 Mar; 197(5):625-32. PubMed ID: 12615903
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Ca(2+)-induced inhibition of apoptosis in human SH-SY5Y neuroblastoma cells: degradation of apoptotic protease activating factor-1 (APAF-1).
    Reimertz C; Kögel D; Lankiewicz S; Poppe M; Prehn JH
    J Neurochem; 2001 Sep; 78(6):1256-66. PubMed ID: 11579134
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis.
    Hu Y; Benedict MA; Ding L; Núñez G
    EMBO J; 1999 Jul; 18(13):3586-95. PubMed ID: 10393175
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1.
    Jiang X; Wang X
    J Biol Chem; 2000 Oct; 275(40):31199-203. PubMed ID: 10940292
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A novel Apaf-1-independent putative caspase-2 activation complex.
    Read SH; Baliga BC; Ekert PG; Vaux DL; Kumar S
    J Cell Biol; 2002 Dec; 159(5):739-45. PubMed ID: 12460989
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.