BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

484 related articles for article (PubMed ID: 12809514)

  • 1. Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.
    Lewis HD; Pérez Revuelta BI; Nadin A; Neduvelil JG; Harrison T; Pollack SJ; Shearman MS
    Biochemistry; 2003 Jun; 42(24):7580-6. PubMed ID: 12809514
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.
    Barten DM; Guss VL; Corsa JA; Loo A; Hansel SB; Zheng M; Munoz B; Srinivasan K; Wang B; Robertson BJ; Polson CT; Wang J; Roberts SB; Hendrick JP; Anderson JJ; Loy JK; Denton R; Verdoorn TA; Smith DW; Felsenstein KM
    J Pharmacol Exp Ther; 2005 Feb; 312(2):635-43. PubMed ID: 15452193
    [TBL] [Abstract][Full Text] [Related]  

  • 3. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
    Lefranc-Jullien S; Sunyach C; Checler F
    J Neurochem; 2006 May; 97(3):807-17. PubMed ID: 16524370
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
    Steiner H; Winkler E; Shearman MS; Prywes R; Haass C
    Neurobiol Dis; 2001 Aug; 8(4):717-22. PubMed ID: 11493036
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
    De Strooper B; Annaert W; Cupers P; Saftig P; Craessaerts K; Mumm JS; Schroeter EH; Schrijvers V; Wolfe MS; Ray WJ; Goate A; Kopan R
    Nature; 1999 Apr; 398(6727):518-22. PubMed ID: 10206645
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells.
    Petit A; St George-Hyslop P; Fraser P; Checler F
    Biochem Biophys Res Commun; 2002 Feb; 290(5):1408-10. PubMed ID: 11820778
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
    J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
    Kimberly WT; Esler WP; Ye W; Ostaszewski BL; Gao J; Diehl T; Selkoe DJ; Wolfe MS
    Biochemistry; 2003 Jan; 42(1):137-44. PubMed ID: 12515548
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Nicastrin binds to membrane-tethered Notch.
    Chen F; Yu G; Arawaka S; Nishimura M; Kawarai T; Yu H; Tandon A; Supala A; Song YQ; Rogaeva E; Milman P; Sato C; Yu C; Janus C; Lee J; Song L; Zhang L; Fraser PE; St George-Hyslop PH
    Nat Cell Biol; 2001 Aug; 3(8):751-4. PubMed ID: 11483961
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
    Irizarry MC; Deng A; Lleo A; Berezovska O; Von Arnim CA; Martin-Rehrmann M; Manelli A; LaDu MJ; Hyman BT; Rebeck GW
    J Neurochem; 2004 Sep; 90(5):1132-43. PubMed ID: 15312168
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
    Esler WP; Kimberly WT; Ostaszewski BL; Diehl TS; Moore CL; Tsai JY; Rahmati T; Xia W; Selkoe DJ; Wolfe MS
    Nat Cell Biol; 2000 Jul; 2(7):428-34. PubMed ID: 10878808
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
    Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
    [TBL] [Abstract][Full Text] [Related]  

  • 15. [Amyloid-beta 42 generating process may have a biological role in regulation of Notch signaling intensity].
    Tagami S; Okochi M; Fukumori A; Takeda M
    Nihon Shinkei Seishin Yakurigaku Zasshi; 2008 Nov; 28(5-6):177-83. PubMed ID: 19108503
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease.
    Pollack SJ; Lewis H
    Curr Opin Investig Drugs; 2005 Jan; 6(1):35-47. PubMed ID: 15675602
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface.
    Kaether C; Schmitt S; Willem M; Haass C
    Traffic; 2006 Apr; 7(4):408-15. PubMed ID: 16536739
    [TBL] [Abstract][Full Text] [Related]  

  • 18. New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage.
    Petit A; Bihel F; Alvès da Costa C; Pourquié O; Checler F; Kraus JL
    Nat Cell Biol; 2001 May; 3(5):507-11. PubMed ID: 11331880
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
    Li G; Percontino L; Sun Q; Qazi AS; Frederikse PH
    Mol Vis; 2003 May; 9():179-83. PubMed ID: 12740567
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes.
    Wang J; Brunkan AL; Hecimovic S; Walker E; Goate A
    Neurobiol Dis; 2004 Apr; 15(3):654-66. PubMed ID: 15056474
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 25.