These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

483 related articles for article (PubMed ID: 12809514)

  • 41. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.
    Zhang Z; Nadeau P; Song W; Donoviel D; Yuan M; Bernstein A; Yankner BA
    Nat Cell Biol; 2000 Jul; 2(7):463-5. PubMed ID: 10878814
    [No Abstract]   [Full Text] [Related]  

  • 42. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
    J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
    Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; Johnston JA
    Biochem J; 2005 Jan; 385(Pt 2):545-50. PubMed ID: 15473868
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Mutations in APP have independent effects on Abeta and CTFgamma generation.
    Hecimovic S; Wang J; Dolios G; Martinez M; Wang R; Goate AM
    Neurobiol Dis; 2004 Nov; 17(2):205-18. PubMed ID: 15474359
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Intracellular generation of amyloid beta-protein from amyloid beta-protein precursor fragment by direct cleavage with beta- and gamma-secretase.
    Iizuka T; Shoji M; Kawarabayashi T; Sato M; Kobayashi T; Tada N; Kasai K; Matsubara E; Watanabe M; Tomidokoro Y; Hirai S
    Biochem Biophys Res Commun; 1996 Jan; 218(1):238-42. PubMed ID: 8573139
    [TBL] [Abstract][Full Text] [Related]  

  • 46. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.
    Walsh DM; Fadeeva JV; LaVoie MJ; Paliga K; Eggert S; Kimberly WT; Wasco W; Selkoe DJ
    Biochemistry; 2003 Jun; 42(22):6664-73. PubMed ID: 12779321
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.
    Wrigley JD; Nunn EJ; Nyabi O; Clarke EE; Hunt P; Nadin A; De Strooper B; Shearman MS; Beher D
    J Neurochem; 2004 Sep; 90(6):1312-20. PubMed ID: 15341515
    [TBL] [Abstract][Full Text] [Related]  

  • 48. beta-Secretase, APP and Abeta in Alzheimer's disease.
    Vassar R
    Subcell Biochem; 2005; 38():79-103. PubMed ID: 15709474
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Intracellular pH regulates amyloid precursor protein intracellular domain accumulation.
    Vingtdeux V; Hamdane M; Bégard S; Loyens A; Delacourte A; Beauvillain JC; Buée L; Marambaud P; Sergeant N
    Neurobiol Dis; 2007 Mar; 25(3):686-96. PubMed ID: 17207630
    [TBL] [Abstract][Full Text] [Related]  

  • 50. Alzheimer's disease and Notch signaling.
    Woo HN; Park JS; Gwon AR; Arumugam TV; Jo DG
    Biochem Biophys Res Commun; 2009 Dec; 390(4):1093-7. PubMed ID: 19853579
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Identity and function of gamma-secretase.
    Kimberly WT; Wolfe MS
    J Neurosci Res; 2003 Nov; 74(3):353-60. PubMed ID: 14598311
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I; Hawkins J; Harrison D; Hille C; Wayne G; Cutler L; Buck T; Walter D; Demont E; Howes C; Naylor A; Jeffrey P; Gonzalez MI; Dingwall C; Michel A; Redshaw S; Davis JB
    J Neurochem; 2007 Feb; 100(3):802-9. PubMed ID: 17156133
    [TBL] [Abstract][Full Text] [Related]  

  • 53. The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.
    Laudon H; Winblad B; Näslund J
    Physiol Behav; 2007 Sep; 92(1-2):115-20. PubMed ID: 17588625
    [TBL] [Abstract][Full Text] [Related]  

  • 54. [Beta-amyloid protein: recent progress in basic research and therapeutic approaches].
    Iwatsubo T
    Rinsho Shinkeigaku; 2001 Dec; 41(12):1198-200. PubMed ID: 12235837
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
    Peng Y; Jiang L; Lee DY; Schachter SC; Ma Z; Lemere CA
    J Neurosci Res; 2006 Sep; 84(4):903-11. PubMed ID: 16862548
    [TBL] [Abstract][Full Text] [Related]  

  • 56. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein.
    Na CH; Jeon SH; Zhang G; Olson GL; Chae CB
    J Neurochem; 2007 Jun; 101(6):1583-95. PubMed ID: 17542811
    [TBL] [Abstract][Full Text] [Related]  

  • 57. gamma-Secretase can cleave amyloid precursor protein fragments independent of alpha- and beta-secretase pre-cutting.
    Kume H; Sekijima Y; Maruyama K; Kametani F
    Int J Mol Med; 2003 Jul; 12(1):57-60. PubMed ID: 12792809
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Mutations in the transmembrane domain of APP altering gamma-secretase specificity.
    Lichtenthaler SF; Ida N; Multhaup G; Masters CL; Beyreuther K
    Biochemistry; 1997 Dec; 36(49):15396-403. PubMed ID: 9398269
    [TBL] [Abstract][Full Text] [Related]  

  • 59. Identification of a novel aspartic protease (Asp 2) as beta-secretase.
    Hussain I; Powell D; Howlett DR; Tew DG; Meek TD; Chapman C; Gloger IS; Murphy KE; Southan CD; Ryan DM; Smith TS; Simmons DL; Walsh FS; Dingwall C; Christie G
    Mol Cell Neurosci; 1999 Dec; 14(6):419-27. PubMed ID: 10656250
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Aspartic proteases involved in Alzheimer's disease.
    Schmidt B
    Chembiochem; 2003 May; 4(5):366-78. PubMed ID: 12740808
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 25.