These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

268 related articles for article (PubMed ID: 12815069)

  • 1. Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis.
    Yang QH; Church-Hajduk R; Ren J; Newton ML; Du C
    Genes Dev; 2003 Jun; 17(12):1487-96. PubMed ID: 12815069
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.
    Suzuki Y; Takahashi-Niki K; Akagi T; Hashikawa T; Takahashi R
    Cell Death Differ; 2004 Feb; 11(2):208-16. PubMed ID: 14605674
    [TBL] [Abstract][Full Text] [Related]  

  • 3. X-linked inhibitor of apoptosis (XIAP) blocks Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial activation: sensitization by overexpression of second mitochondria-derived activator of caspase/direct IAP-binding protein with low pl (Smac/DIABLO).
    Ng CP; Bonavida B
    Mol Cancer Ther; 2002 Oct; 1(12):1051-8. PubMed ID: 12481428
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.
    Srinivasula SM; Gupta S; Datta P; Zhang Z; Hegde R; Cheong N; Fernandes-Alnemri T; Alnemri ES
    J Biol Chem; 2003 Aug; 278(34):31469-72. PubMed ID: 12835328
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.
    Martins LM; Turk BE; Cowling V; Borg A; Jarrell ET; Cantley LC; Downward J
    J Biol Chem; 2003 Dec; 278(49):49417-27. PubMed ID: 14512424
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.
    Yang QH; Du C
    J Biol Chem; 2004 Apr; 279(17):16963-70. PubMed ID: 14960576
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
    Srinivasula SM; Datta P; Fan XJ; Fernandes-Alnemri T; Huang Z; Alnemri ES
    J Biol Chem; 2000 Nov; 275(46):36152-7. PubMed ID: 10950947
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition.
    Wilkinson JC; Wilkinson AS; Scott FL; Csomos RA; Salvesen GS; Duckett CS
    J Biol Chem; 2004 Dec; 279(49):51082-90. PubMed ID: 15371416
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells.
    Bockbrader KM; Tan M; Sun Y
    Oncogene; 2005 Nov; 24(49):7381-8. PubMed ID: 16044155
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif.
    Martins LM; Iaccarino I; Tenev T; Gschmeissner S; Totty NF; Lemoine NR; Savopoulos J; Gray CW; Creasy CL; Dingwall C; Downward J
    J Biol Chem; 2002 Jan; 277(1):439-44. PubMed ID: 11602612
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.
    Martins LM; Morrison A; Klupsch K; Fedele V; Moisoi N; Teismann P; Abuin A; Grau E; Geppert M; Livi GP; Creasy CL; Martin A; Hargreaves I; Heales SJ; Okada H; Brandner S; Schulz JB; Mak T; Downward J
    Mol Cell Biol; 2004 Nov; 24(22):9848-62. PubMed ID: 15509788
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's Disease.
    Goffredo D; Rigamonti D; Zuccato C; Tartari M; Valenza M; Cattaneo E
    Pharmacol Res; 2005 Aug; 52(2):140-50. PubMed ID: 15967379
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.
    Suzuki Y; Imai Y; Nakayama H; Takahashi K; Takio K; Takahashi R
    Mol Cell; 2001 Sep; 8(3):613-21. PubMed ID: 11583623
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis.
    Sosna J; Voigt S; Mathieu S; Kabelitz D; Trad A; Janssen O; Meyer-Schwesinger C; Schütze S; Adam D
    Cell Commun Signal; 2013 Oct; 11():76. PubMed ID: 24090154
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Endogenously released Smac is insufficient to mediate cell death of human lung carcinoma in response to etoposide.
    Bartling B; Lewensohn R; Zhivotovsky B
    Exp Cell Res; 2004 Aug; 298(1):83-95. PubMed ID: 15242764
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction.
    Hegde R; Srinivasula SM; Zhang Z; Wassell R; Mukattash R; Cilenti L; DuBois G; Lazebnik Y; Zervos AS; Fernandes-Alnemri T; Alnemri ES
    J Biol Chem; 2002 Jan; 277(1):432-8. PubMed ID: 11606597
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase.
    Yan H; Brouha B; Liu T; Raj D; Biddle D; Lee R; Grossman D
    J Dermatol Sci; 2006 Sep; 43(3):189-200. PubMed ID: 16806840
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mammalian mitochondrial IAP binding proteins.
    Vaux DL; Silke J
    Biochem Biophys Res Commun; 2003 May; 304(3):499-504. PubMed ID: 12729584
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15.
    Trencia A; Fiory F; Maitan MA; Vito P; Barbagallo AP; Perfetti A; Miele C; Ungaro P; Oriente F; Cilenti L; Zervos AS; Formisano P; Beguinot F
    J Biol Chem; 2004 Nov; 279(45):46566-72. PubMed ID: 15328349
    [TBL] [Abstract][Full Text] [Related]  

  • 20. THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.
    Balakrishnan MP; Cilenti L; Mashak Z; Popat P; Alnemri ES; Zervos AS
    Am J Physiol Heart Circ Physiol; 2009 Aug; 297(2):H643-53. PubMed ID: 19502560
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.