BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

186 related articles for article (PubMed ID: 12816949)

  • 1. Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase.
    Hiromasa Y; Roche TE
    J Biol Chem; 2003 Sep; 278(36):33681-93. PubMed ID: 12816949
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Marked differences between two isoforms of human pyruvate dehydrogenase kinase.
    Baker JC; Yan X; Peng T; Kasten S; Roche TE
    J Biol Chem; 2000 May; 275(21):15773-81. PubMed ID: 10748134
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.
    Bao H; Kasten SA; Yan X; Roche TE
    Biochemistry; 2004 Oct; 43(42):13432-41. PubMed ID: 15491150
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP.
    Bao H; Kasten SA; Yan X; Hiromasa Y; Roche TE
    Biochemistry; 2004 Oct; 43(42):13442-51. PubMed ID: 15491151
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Binding of the pyruvate dehydrogenase kinase to recombinant constructs containing the inner lipoyl domain of the dihydrolipoyl acetyltransferase component.
    Liu S; Baker JC; Roche TE
    J Biol Chem; 1995 Jan; 270(2):793-800. PubMed ID: 7822313
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activity.
    Ravindran S; Radke GA; Guest JR; Roche TE
    J Biol Chem; 1996 Jan; 271(2):653-62. PubMed ID: 8557670
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Partial activation of the pyruvate dehydrogenase kinase by the lipoyl domain region of E2 and interchange of the kinase between lipoyl domain regions.
    Ono K; Radke GA; Roche TE; Rahmatullah M
    J Biol Chem; 1993 Dec; 268(35):26135-43. PubMed ID: 8253731
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates.
    Liu S; Gong X; Yan X; Peng T; Baker JC; Li L; Robben PM; Ravindran S; Andersson LA; Cole AB; Roche TE
    Arch Biochem Biophys; 2001 Feb; 386(2):123-35. PubMed ID: 11368334
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Requirements for the adaptor protein role of dihydrolipoyl acetyltransferase in the up-regulated function of the pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
    Yang D; Gong X; Yakhnin A; Roche TE
    J Biol Chem; 1998 Jun; 273(23):14130-7. PubMed ID: 9603912
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Assembly and full functionality of recombinantly expressed dihydrolipoyl acetyltransferase component of the human pyruvate dehydrogenase complex.
    Yang D; Song J; Wagenknecht T; Roche TE
    J Biol Chem; 1997 Mar; 272(10):6361-9. PubMed ID: 9045657
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Activated function of the pyruvate dehydrogenase phosphatase through Ca2+-facilitated binding to the inner lipoyl domain of the dihydrolipoyl acetyltransferase.
    Chen G; Wang L; Liu S; Chuang C; Roche TE
    J Biol Chem; 1996 Nov; 271(45):28064-70. PubMed ID: 8910418
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.
    Hiromasa Y; Hu L; Roche TE
    J Biol Chem; 2006 May; 281(18):12568-79. PubMed ID: 16517984
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Recombinant expression and evaluation of the lipoyl domains of the dihydrolipoyl acetyltransferase component of the human pyruvate dehydrogenase complex.
    Liu S; Baker JC; Andrews PC; Roche TE
    Arch Biochem Biophys; 1995 Feb; 316(2):926-40. PubMed ID: 7864652
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r.
    Hiromasa Y; Yan X; Roche TE
    Biochemistry; 2008 Feb; 47(8):2312-24. PubMed ID: 18220415
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.
    Hiromasa Y; Fujisawa T; Aso Y; Roche TE
    J Biol Chem; 2004 Feb; 279(8):6921-33. PubMed ID: 14638692
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex.
    Tuganova A; Boulatnikov I; Popov KM
    Biochem J; 2002 Aug; 366(Pt 1):129-36. PubMed ID: 11978179
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Critical role of a lipoyl cofactor of the dihydrolipoyl acetyltransferase in the binding and enhanced function of the pyruvate dehydrogenase kinase.
    Radke GA; Ono K; Ravindran S; Roche TE
    Biochem Biophys Res Commun; 1993 Feb; 190(3):982-91. PubMed ID: 8439347
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer.
    Roche TE; Hiromasa Y
    Cell Mol Life Sci; 2007 Apr; 64(7-8):830-49. PubMed ID: 17310282
    [TBL] [Abstract][Full Text] [Related]  

  • 19. R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase.
    Korotchkina LG; Sidhu S; Patel MS
    Free Radic Res; 2004 Oct; 38(10):1083-92. PubMed ID: 15512796
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nematode pyruvate dehydrogenase kinases: role of the C-terminus in binding to the dihydrolipoyl transacetylase core of the pyruvate dehydrogenase complex.
    Chen W; Komuniecki PR; Komuniecki R
    Biochem J; 1999 Apr; 339 ( Pt 1)(Pt 1):103-9. PubMed ID: 10085233
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.