These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
132 related articles for article (PubMed ID: 12824026)
1. Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. South MS; Case BL; Wood RS; Jones DE; Hayes MJ; Girard TJ; Lachance RM; Nicholson NS; Clare M; Stevens AM; Stegeman RA; Stallings WC; Kurumbail RG; Parlow JJ Bioorg Med Chem Lett; 2003 Jul; 13(14):2319-25. PubMed ID: 12824026 [TBL] [Abstract][Full Text] [Related]
2. Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. Parlow JJ; Case BL; Dice TA; Fenton RL; Hayes MJ; Jones DE; Neumann WL; Wood RS; Lachance RM; Girard TJ; Nicholson NS; Clare M; Stegeman RA; Stevens AM; Stallings WC; Kurumbail RG; South MS J Med Chem; 2003 Sep; 46(19):4050-62. PubMed ID: 12954058 [TBL] [Abstract][Full Text] [Related]
3. Polymer-assisted solution-phase (PASP) parallel synthesis of an alpha-ketothiazole library as tissue factor VIIa inhibitors. South MS; Dice TA; Girard TJ; Lachance RM; Stevens AM; Stegeman RA; Stallings WC; Kurumbail RG; Parlow JJ Bioorg Med Chem Lett; 2003 Jul; 13(14):2363-7. PubMed ID: 12824035 [TBL] [Abstract][Full Text] [Related]
4. Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa. Schweitzer BA; Neumann WL; Rahman HK; Kusturin CL; Sample KR; Poda GI; Kurumbail RG; Stevens AM; Stegeman RA; Stallings WC; South MS Bioorg Med Chem Lett; 2005 Jun; 15(12):3006-11. PubMed ID: 15913999 [TBL] [Abstract][Full Text] [Related]
5. Pharmacological interruption of acute thrombus formation with minimal hemorrhagic complications by a small molecule tissue factor/factor VIIa inhibitor: comparison to factor Xa and thrombin inhibition in a nonhuman primate thrombosis model. Suleymanov OD; Szalony JA; Salyers AK; LaChance RM; Parlow JJ; South MS; Wood RS; Nicholson NS J Pharmacol Exp Ther; 2003 Sep; 306(3):1115-21. PubMed ID: 12829728 [TBL] [Abstract][Full Text] [Related]
6. Synthesis and crystal structures of substituted benzenes and benzoquinones as tissue factor VIIa inhibitors. Parlow JJ; Stevens AM; Stegeman RA; Stallings WC; Kurumbail RG; South MS J Med Chem; 2003 Sep; 46(20):4297-312. PubMed ID: 13678408 [TBL] [Abstract][Full Text] [Related]
7. Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents. Ries UJ; Priepke HW; Hauel NH; Handschuh S; Mihm G; Stassen JM; Wienen W; Nar H Bioorg Med Chem Lett; 2003 Jul; 13(14):2297-302. PubMed ID: 12824021 [TBL] [Abstract][Full Text] [Related]
8. Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors. Parlow JJ; Dice TA; Lachance RM; Girard TJ; Stevens AM; Stegeman RA; Stallings WC; Kurumbail RG; South MS J Med Chem; 2003 Sep; 46(19):4043-9. PubMed ID: 12954057 [TBL] [Abstract][Full Text] [Related]
9. Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors. Groebke Zbinden K; Banner DW; Ackermann J; D'Arcy A; Kirchhofer D; Ji YH; Tschopp TB; Wallbaum S; Weber L Bioorg Med Chem Lett; 2005 Feb; 15(3):817-22. PubMed ID: 15664864 [TBL] [Abstract][Full Text] [Related]
10. Design, synthesis, and crystal structure of selective 2-pyridone tissue factor VIIa inhibitors. Parlow JJ; Kurumbail RG; Stegeman RA; Stevens AM; Stallings WC; South MS J Med Chem; 2003 Oct; 46(22):4696-701. PubMed ID: 14561089 [TBL] [Abstract][Full Text] [Related]
11. Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors. Zhang X; Glunz PW; Jiang W; Schmitt A; Newman M; Barbera FA; Bozarth JM; Rendina AR; Wei A; Wen X; Rossi KA; Luettgen JM; Wong PC; Knabb RM; Wexler RR; Scott Priestley E Bioorg Med Chem Lett; 2013 Mar; 23(6):1604-7. PubMed ID: 23416003 [TBL] [Abstract][Full Text] [Related]
12. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. Costanzo MJ; Almond HR; Hecker LR; Schott MR; Yabut SC; Zhang HC; Andrade-Gordon P; Corcoran TW; Giardino EC; Kauffman JA; Lewis JM; de Garavilla L; Haertlein BJ; Maryanoff BE J Med Chem; 2005 Mar; 48(6):1984-2008. PubMed ID: 15771442 [TBL] [Abstract][Full Text] [Related]
13. The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex. Kohrt JT; Filipski KJ; Cody WL; Cai C; Dudley DA; Van Huis CA; Willardsen JA; Rapundalo ST; Saiya-Cork K; Leadley RJ; Narasimhan L; Zhang E; Whitlow M; Adler M; McLean K; Chou YL; McKnight C; Arnaiz DO; Shaw KJ; Light DR; Edmunds JJ Bioorg Med Chem Lett; 2005 Nov; 15(21):4752-6. PubMed ID: 16125385 [TBL] [Abstract][Full Text] [Related]
14. Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores. Kotian PL; Krishnan R; Rowland S; El-Kattan Y; Saini SK; Upshaw R; Bantia S; Arnold S; Babu YS; Chand P Bioorg Med Chem; 2009 Jun; 17(11):3934-58. PubMed ID: 19409795 [TBL] [Abstract][Full Text] [Related]
15. Synthesis and X-ray crystal structures of substituted fluorobenzene and benzoquinone inhibitors of the tissue factor VIIa complex. Parlow JJ; Kurumbail RG; Stegeman RA; Stevens AM; Stallings WC; South MS Bioorg Med Chem Lett; 2003 Nov; 13(21):3721-5. PubMed ID: 14552766 [TBL] [Abstract][Full Text] [Related]
16. Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2. Quan ML; Ellis CD; Liauw AY; Alexander RS; Knabb RM; Lam G; Wright MR; Wong PC; Wexler RR J Med Chem; 1999 Jul; 42(15):2760-73. PubMed ID: 10425087 [TBL] [Abstract][Full Text] [Related]
17. Selective tissue factor/factor VIIa Inhibitor, ER-410660, and its prodrug, E5539, have anti-venous and anti-arterial thrombotic effects with a low risk of bleeding. Nagakura T; Tabata K; Kira K; Hirota S; Clark R; Matsuura F; Hiyoshi H Thromb Res; 2013 Aug; 132(2):271-9. PubMed ID: 23827699 [TBL] [Abstract][Full Text] [Related]
18. Design, synthesis, and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors. Phillips G; Davey DD; Eagen KA; Koovakkat SK; Liang A; Ng HP; Pinkerton M; Trinh L; Whitlow M; Beatty AM; Morrissey MM J Med Chem; 1999 May; 42(10):1749-56. PubMed ID: 10346927 [TBL] [Abstract][Full Text] [Related]
19. Probing the S2 site of factor VIIa to generate potent and selective inhibitors: the structure of BCX-3607 in complex with tissue factor-factor VIIa. Krishnan R; Kotian PL; Chand P; Bantia S; Rowland S; Babu YS Acta Crystallogr D Biol Crystallogr; 2007 Jun; 63(Pt 6):689-97. PubMed ID: 17505107 [TBL] [Abstract][Full Text] [Related]
20. Structure-based design of amidinophenylurea-derivatives for factor VIIa inhibition. Klingler O; Matter H; Schudok M; Donghi M; Czech J; Lorenz M; Nestler HP; Szillat H; Schreuder H Bioorg Med Chem Lett; 2004 Jul; 14(14):3715-20. PubMed ID: 15203149 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]