173 related articles for article (PubMed ID: 12825936)
1. Design, synthesis, and evaluation of psorospermin/quinobenzoxazine hybrids as structurally novel antitumor agents.
Kim MY; Na Y; Vankayalapati H; Gleason-Guzman M; Hurley LH
J Med Chem; 2003 Jul; 46(14):2958-72. PubMed ID: 12825936
[TBL] [Abstract][Full Text] [Related]
2. Conformationally restricted analogues of psorospermin: design, synthesis, and bioactivity of natural-product-related bisfuranoxanthones.
Heald RA; Dexheimer TS; Vankayalapati H; Siddiqui-Jain A; Szabo LZ; Gleason-Guzman MC; Hurley LH
J Med Chem; 2005 Apr; 48(8):2993-3004. PubMed ID: 15828838
[TBL] [Abstract][Full Text] [Related]
3. Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model.
Zeng Q; Kwok Y; Kerwin SM; Mangold G; Hurley LH
J Med Chem; 1998 Oct; 41(22):4273-8. PubMed ID: 9784102
[TBL] [Abstract][Full Text] [Related]
4. Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes.
Kim MY; Duan W; Gleason-Guzman M; Hurley LH
J Med Chem; 2003 Feb; 46(4):571-83. PubMed ID: 12570378
[TBL] [Abstract][Full Text] [Related]
5. Topoisomerase II site-directed alkylation of DNA by psorospermin and its effect on topoisomerase II-mediated DNA cleavage.
Kwok Y; Hurley LH
J Biol Chem; 1998 Dec; 273(49):33020-6. PubMed ID: 9830055
[TBL] [Abstract][Full Text] [Related]
6. Synthesis of new xanthone analogues and their biological activity test--cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study.
Woo S; Jung J; Lee C; Kwon Y; Na Y
Bioorg Med Chem Lett; 2007 Mar; 17(5):1163-6. PubMed ID: 17194586
[TBL] [Abstract][Full Text] [Related]
7. DNA-Directed alkylating agents. 7. Synthesis, DNA interaction, and antitumor activity of bis(hydroxymethyl)- and bis(carbamate)-substituted pyrrolizines and imidazoles.
Atwell GJ; Fan JY; Tan K; Denny WA
J Med Chem; 1998 Nov; 41(24):4744-54. PubMed ID: 9822545
[TBL] [Abstract][Full Text] [Related]
8. Studies of pyrrolo[1,2-alpha]benzimidazolequinone DT-diaphorase substrate activity, topoisomerase II inhibition activity, and DNA reductive alkylation.
Skibo EB; Gordon S; Bess L; Boruah R; Heileman MJ
J Med Chem; 1997 Apr; 40(9):1327-39. PubMed ID: 9135030
[TBL] [Abstract][Full Text] [Related]
9. Structure-activity studies of novel amidine analogues of chlorambucil: correlation of cytotoxic activity with DNA-binding affinity and topoisomerase II inhibition.
Bielawska A; Bielawski K; Wołczyński S; Anchim T
Arch Pharm (Weinheim); 2003 Aug; 336(6-7):293-9. PubMed ID: 12953217
[TBL] [Abstract][Full Text] [Related]
10. Synthesis, cytotoxic activity, DNA topoisomerase-II inhibition, molecular modeling and structure-activity relationship of 9-anilinothiazolo[5,4-b]quinoline derivatives.
Loza-Mejía MA; Olvera-Vázquez S; Maldonado-Hernández K; Guadarrama-Salgado T; González-Sánchez I; Rodríguez-Hernández F; Solano JD; Rodríguez-Sotres R; Lira-Rocha A
Bioorg Med Chem; 2009 May; 17(9):3266-77. PubMed ID: 19364657
[TBL] [Abstract][Full Text] [Related]
11. Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites.
Kwok Y; Zeng Q; Hurley LH
Proc Natl Acad Sci U S A; 1998 Nov; 95(23):13531-6. PubMed ID: 9811834
[TBL] [Abstract][Full Text] [Related]
12. Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity.
Su TL; Lin YW; Chou TC; Zhang X; Bacherikov VA; Chen CH; Liu LF; Tsai TJ
J Med Chem; 2006 Jun; 49(12):3710-8. PubMed ID: 16759114
[TBL] [Abstract][Full Text] [Related]
13. Structural insight into a quinolone-topoisomerase II-DNA complex. Further evidence for a 2:2 quinobenzoxazine-mg2+ self-assembly model formed in the presence of topoisomerase ii.
Kwok Y; Zeng Q; Hurley LH
J Biol Chem; 1999 Jun; 274(24):17226-35. PubMed ID: 10358081
[TBL] [Abstract][Full Text] [Related]
14. Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity.
Arimondo P; Boukarim C; Bailly C; Dauzonne D; Monneret C
Anticancer Drug Des; 2000 Dec; 15(6):413-21. PubMed ID: 11716434
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and antitumour activities of tetracyclic quinolone antineoplastic agents.
Chu DT; Hallas R; Tanaka SK; Alder J; Balli D; Plattner JJ
Drugs Exp Clin Res; 1994; 20(5):177-83. PubMed ID: 7875053
[TBL] [Abstract][Full Text] [Related]
16. Novel antitumor indenoindole derivatives targeting DNA and topoisomerase II.
Bal C; Baldeyrou B; Moz F; Lansiaux A; Colson P; Kraus-Berthier L; Léonce S; Pierré A; Boussard MF; Rousseau A; Wierzbicki M; Bailly C
Biochem Pharmacol; 2004 Nov; 68(10):1911-22. PubMed ID: 15476662
[TBL] [Abstract][Full Text] [Related]
17. Novel DNA-directed alkylating agents consisting of naphthalimide, nitrogen mustard and lexitropsin moieties: synthesis, DNA sequence specificity and biological evaluation.
Gupta R; Liu J; Xie G; Lown JW
Anticancer Drug Des; 1996 Dec; 11(8):581-96. PubMed ID: 9022747
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
Baraldi PG; Balboni G; Pavani MG; Spalluto G; Tabrizi MA; Clercq ED; Balzarini J; Bando T; Sugiyama H; Romagnoli R
J Med Chem; 2001 Aug; 44(16):2536-43. PubMed ID: 11472207
[TBL] [Abstract][Full Text] [Related]
19. Determination of the importance of the stereochemistry of psorospermin in topoisomerase II-induced alkylation of DNA and in vitro and in vivo biological activity.
Fellows IM; Schwaebe M; Dexheimer TS; Vankayalapati H; Gleason-Guzman M; Whitten JP; Hurley LH
Mol Cancer Ther; 2005 Nov; 4(11):1729-39. PubMed ID: 16275994
[TBL] [Abstract][Full Text] [Related]
20. Small-molecule based delivery systems for alkylating antineoplastic compounds.
Bielawski K; Bielawska A
ChemMedChem; 2008 Apr; 3(4):536-42. PubMed ID: 18157855
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
