148 related articles for article (PubMed ID: 12825948)
1. Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids.
Conti P; De Amici M; Joppolo Di Ventimiglia S; Stensbøl TB; Madsen U; Bräuner-Osborne H; Russo E; De Sarro G; Bruno G; De Micheli C
J Med Chem; 2003 Jul; 46(14):3102-8. PubMed ID: 12825948
[TBL] [Abstract][Full Text] [Related]
2. 4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues.
Lolli ML; Giordano C; Pickering DS; Rolando B; Hansen KB; Foti A; Contreras-Sanz A; Amir A; Fruttero R; Gasco A; Nielsen B; Johansen TN
J Med Chem; 2010 May; 53(10):4110-8. PubMed ID: 20408529
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists.
Conti P; De Amici M; Grazioso G; Roda G; Barberis Negra FF; Nielsen B; Stensbøl TB; Madsen U; Bräuner-Osborne H; Frydenvang K; De Sarro G; Toma L; De Micheli C
J Med Chem; 2004 Dec; 47(27):6740-8. PubMed ID: 15615523
[TBL] [Abstract][Full Text] [Related]
4. Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.
Conti P; De Amici M; Grazioso G; Roda G; Pinto A; Hansen KB; Nielsen B; Madsen U; Bräuner-Osborne H; Egebjerg J; Vestri V; Pellegrini-Giampietro DE; Sibille P; Acher FC; De Micheli C
J Med Chem; 2005 Oct; 48(20):6315-25. PubMed ID: 16190758
[TBL] [Abstract][Full Text] [Related]
5. Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists.
Nakazato A; Kumagai T; Sakagami K; Yoshikawa R; Suzuki Y; Chaki S; Ito H; Taguchi T; Nakanishi S; Okuyama S
J Med Chem; 2000 Dec; 43(25):4893-909. PubMed ID: 11123999
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors.
Madsen U; Bräuner-Osborne H; Frydenvang K; Hvene L; Johansen TN; Nielsen B; Sánchez C; Stensbøl TB; Bischoff F; Krogsgaard-Larsen P
J Med Chem; 2001 Mar; 44(7):1051-9. PubMed ID: 11297452
[TBL] [Abstract][Full Text] [Related]
7. Synthesis of conformationally constrained glutamic acid homologues and investigation of their pharmacological profiles.
Conti P; Pinto A; Tamborini L; Grazioso G; De Sarro G; Bräuner-Osborne H; Szabo G; Gábor Hársing L; De Micheli C
ChemMedChem; 2007 Nov; 2(11):1639-47. PubMed ID: 17849399
[TBL] [Abstract][Full Text] [Related]
8. Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.
Johansen TN; Ebert B; Bräuner-Osborne H; Didriksen M; Christensen IT; Søby KK; Madsen U; Krogsgaard-Larsen P; Brehm L
J Med Chem; 1998 Mar; 41(6):930-9. PubMed ID: 9526567
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
Kozikowski AP; Steensma D; Araldi GL; Tückmantel W; Wang S; Pshenichkin S; Surina E; Wroblewski JT
J Med Chem; 1998 May; 41(10):1641-50. PubMed ID: 9572889
[TBL] [Abstract][Full Text] [Related]
10. N-methyl-D-aspartic acid receptor agonists: resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.
Madsen U; Frydenvang K; Ebert B; Johansen TN; Brehm L; Krogsgaard-Larsen P
J Med Chem; 1996 Jan; 39(1):183-90. PubMed ID: 8568805
[TBL] [Abstract][Full Text] [Related]
11. 4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity.
Carling RW; Leeson PD; Moore KW; Moyes CR; Duncton M; Hudson ML; Baker R; Foster AC; Grimwood S; Kemp JA; Marshall GR; Tricklebank MD; Saywell KL
J Med Chem; 1997 Feb; 40(5):754-65. PubMed ID: 9057862
[TBL] [Abstract][Full Text] [Related]
12. Synthesis of novel pyrrolo[3,4-d]pyrazole-dicarboxylic acids and evaluation of their interaction with glutamate receptors.
Conti P; di Ventimiglia SJ; Pinto A; Tamborini L; Menniti FS; Lazzaro JT; De Micheli C
Chem Biodivers; 2008 Apr; 5(4):657-63. PubMed ID: 18421758
[TBL] [Abstract][Full Text] [Related]
13. Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: design, synthesis, and pharmacological characterization.
Conti P; Pinto A; Tamborini L; Madsen U; Nielsen B; Bräuner-Osborne H; Hansen KB; Landucci E; Pellegrini-Giampietro DE; De Sarro G; Donato Di Paola E; De Micheli C
ChemMedChem; 2010 Sep; 5(9):1465-75. PubMed ID: 20665761
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and metabotropic glutamate receptor activity of a 2-aminobicyclo[3.2.0]heptane-2,5-dicarboxylic acid, a molecule possessing an extended glutamate conformation.
Kozikowski AP; Araldi GL; Flippen-Anderson J; George C; Pshenichkin S; Surina E; Wroblewski J
Bioorg Med Chem Lett; 1998 Apr; 8(8):925-30. PubMed ID: 9871513
[TBL] [Abstract][Full Text] [Related]
15. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).
Bjerrum EJ; Kristensen AS; Pickering DS; Greenwood JR; Nielsen B; Liljefors T; Schousboe A; Bräuner-Osborne H; Madsen U
J Med Chem; 2003 May; 46(11):2246-9. PubMed ID: 12747796
[TBL] [Abstract][Full Text] [Related]
16. Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology.
Frølund B; Greenwood JR; Holm MM; Egebjerg J; Madsen U; Nielsen B; Bräuner-Osborne H; Stensbøl TB; Krogsgaard-Larsen P
Bioorg Med Chem; 2005 Sep; 13(18):5391-8. PubMed ID: 16043357
[TBL] [Abstract][Full Text] [Related]
17. Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors.
Jørgensen CG; Bräuner-Osborne H; Nielsen B; Kehler J; Clausen RP; Krogsgaard-Larsen P; Madsen U
Bioorg Med Chem; 2007 May; 15(10):3524-38. PubMed ID: 17376693
[TBL] [Abstract][Full Text] [Related]
18. Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.
Johansen TN; Stensbøl TB; Nielsen B; Vogensen SB; Frydenvang K; Sløk FA; Bräüner-Osborne H; Madsen U; Krogsgaard-Larsen P
Chirality; 2001; 13(9):523-32. PubMed ID: 11579444
[TBL] [Abstract][Full Text] [Related]
19. Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.
Hermit MB; Greenwood JR; Nielsen B; Bunch L; Jørgensen CG; Vestergaard HT; Stensbøl TB; Sanchez C; Krogsgaard-Larsen P; Madsen U; Bräuner-Osborne H
Eur J Pharmacol; 2004 Feb; 486(3):241-50. PubMed ID: 14985045
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and pharmacological evaluation of novel conformationally constrained homologues of glutamic acid.
Conti P; Caligiuri A; Pinto A; Roda G; Tamborini L; Nielsen B; Madsen U; Frydenvang K; Colombo A; De Micheli C
Eur J Med Chem; 2007 Aug; 42(8):1059-68. PubMed ID: 17346858
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]