These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

304 related articles for article (PubMed ID: 12837691)

  • 1. ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics.
    Otomo A; Hadano S; Okada T; Mizumura H; Kunita R; Nishijima H; Showguchi-Miyata J; Yanagisawa Y; Kohiki E; Suga E; Yasuda M; Osuga H; Nishimoto T; Narumiya S; Ikeda JE
    Hum Mol Genet; 2003 Jul; 12(14):1671-87. PubMed ID: 12837691
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking.
    Kunita R; Otomo A; Mizumura H; Suzuki K; Showguchi-Miyata J; Yanagisawa Y; Hadano S; Ikeda JE
    J Biol Chem; 2004 Sep; 279(37):38626-35. PubMed ID: 15247254
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function.
    Sato K; Otomo A; Ueda MT; Hiratsuka Y; Suzuki-Utsunomiya K; Sugiyama J; Murakoshi S; Mitsui S; Ono S; Nakagawa S; Shang HF; Hadano S
    J Biol Chem; 2018 Nov; 293(44):17135-17153. PubMed ID: 30224357
    [TBL] [Abstract][Full Text] [Related]  

  • 4. [Recessive motor neuron diseases: mutations in the ALS2 gene and molecular pathogenesis for the upper motor neurodegeneration].
    Ikeda JE
    Rinsho Shinkeigaku; 2004 Nov; 44(11):792-4. PubMed ID: 15651293
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration.
    Hadano S; Kunita R; Otomo A; Suzuki-Utsunomiya K; Ikeda JE
    Neurochem Int; 2007; 51(2-4):74-84. PubMed ID: 17566607
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin.
    Lai C; Xie C; Shim H; Chandran J; Howell BW; Cai H
    Mol Brain; 2009 Jul; 2():23. PubMed ID: 19630956
    [TBL] [Abstract][Full Text] [Related]  

  • 7. ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics.
    Hadano S; Otomo A; Suzuki-Utsunomiya K; Kunita R; Yanagisawa Y; Showguchi-Miyata J; Mizumura H; Ikeda JE
    FEBS Lett; 2004 Sep; 575(1-3):64-70. PubMed ID: 15388334
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The Rab5 activator ALS2/alsin acts as a novel Rac1 effector through Rac1-activated endocytosis.
    Kunita R; Otomo A; Mizumura H; Suzuki-Utsunomiya K; Hadano S; Ikeda JE
    J Biol Chem; 2007 Jun; 282(22):16599-611. PubMed ID: 17409386
    [TBL] [Abstract][Full Text] [Related]  

  • 9. ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes.
    Ono S; Otomo A; Murakoshi S; Mitsui S; Sato K; Fukuda M; Hadano S
    Biochem Biophys Res Commun; 2020 Mar; 523(4):908-915. PubMed ID: 31959474
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2.
    Shimakura K; Sato K; Mitsui S; Ono S; Otomo A; Hadano S
    Biochem Biophys Res Commun; 2021 Sep; 569():106-111. PubMed ID: 34243065
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Infantile-onset ascending hereditary spastic paraplegia with bulbar involvement due to the novel ALS2 mutation c.2761C>T.
    Wakil SM; Ramzan K; Abuthuraya R; Hagos S; Al-Dossari H; Al-Omar R; Murad H; Chedrawi A; Al-Hassnan ZN; Finsterer J; Bohlega S
    Gene; 2014 Feb; 536(1):217-20. PubMed ID: 24315819
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The first ALS2 missense mutation associated with JPLS reveals new aspects of alsin biological function.
    Panzeri C; De Palma C; Martinuzzi A; Daga A; De Polo G; Bresolin N; Miller CC; Tudor EL; Clementi E; Bassi MT
    Brain; 2006 Jul; 129(Pt 7):1710-9. PubMed ID: 16670179
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Vps9 family protein Muk1 is the second Rab5 guanosine nucleotide exchange factor in budding yeast.
    Paulsel AL; Merz AJ; Nickerson DP
    J Biol Chem; 2013 Jun; 288(25):18162-71. PubMed ID: 23612966
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Rab5 activation on macropinosomes requires ALS2, and subsequent Rab5 inactivation through ALS2 detachment requires active Rab7.
    Morishita S; Wada N; Fukuda M; Nakamura T
    FEBS Lett; 2019 Jan; 593(2):230-241. PubMed ID: 30485418
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics.
    Zhang X; He X; Fu XY; Chang Z
    J Cell Sci; 2006 Mar; 119(Pt 6):1053-62. PubMed ID: 16525121
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation.
    Otomo A; Kunita R; Suzuki-Utsunomiya K; Ikeda JE; Hadano S
    FEBS Lett; 2011 Mar; 585(5):730-6. PubMed ID: 21300063
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31.
    Kajiho H; Sakurai K; Minoda T; Yoshikawa M; Nakagawa S; Fukushima S; Kontani K; Katada T
    J Biol Chem; 2011 Jul; 286(27):24364-73. PubMed ID: 21586568
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor.
    Topp JD; Gray NW; Gerard RD; Horazdovsky BF
    J Biol Chem; 2004 Jun; 279(23):24612-23. PubMed ID: 15033976
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes.
    Bean BD; Davey M; Snider J; Jessulat M; Deineko V; Tinney M; Stagljar I; Babu M; Conibear E
    Mol Biol Cell; 2015 Mar; 26(6):1119-28. PubMed ID: 25609093
    [TBL] [Abstract][Full Text] [Related]  

  • 20. RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.
    Kajiho H; Saito K; Tsujita K; Kontani K; Araki Y; Kurosu H; Katada T
    J Cell Sci; 2003 Oct; 116(Pt 20):4159-68. PubMed ID: 12972505
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.