These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

113 related articles for article (PubMed ID: 12842106)

  • 1. Measuring human beta-secretase (BACE1) activity using homogeneous time-resolved fluorescence.
    Kennedy ME; Wang W; Song L; Lee J; Zhang L; Wong G; Wang L; Parker E
    Anal Biochem; 2003 Aug; 319(1):49-55. PubMed ID: 12842106
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The beta-secretase, BACE: a prime drug target for Alzheimer's disease.
    Vassar R
    J Mol Neurosci; 2001 Oct; 17(2):157-70. PubMed ID: 11816789
    [TBL] [Abstract][Full Text] [Related]  

  • 3. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S; Price EA; Wu G; Crouthamel MC; Shi XP; Tugusheva K; Tyler KX; Kahana J; Ellis J; Jin L; Steele T; Stachel S; Coburn C; Simon AJ
    J Pharmacol Exp Ther; 2008 Mar; 324(3):957-69. PubMed ID: 18156464
    [TBL] [Abstract][Full Text] [Related]  

  • 4. BACE1: the beta-secretase enzyme in Alzheimer's disease.
    Vassar R
    J Mol Neurosci; 2004; 23(1-2):105-14. PubMed ID: 15126696
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Fluorogenic quantum dot-gold nanoparticle assembly for beta secretase inhibitor screening in live cell.
    Choi Y; Cho Y; Kim M; Grailhe R; Song R
    Anal Chem; 2012 Oct; 84(20):8595-601. PubMed ID: 22954333
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A microfluidics-based mobility shift assay to identify new inhibitors of β-secretase for Alzheimer's disease.
    Liu R; Liu YC; Meng J; Zhu H; Zhang X
    Anal Bioanal Chem; 2017 Nov; 409(28):6635-6642. PubMed ID: 28889204
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Amplified voltammetric characterization of cleavage of the biotinylated peptide by BACE1 and screening of BACE1 inhibitors.
    Yi X; Han H; Zhang Y; Wang J; Zhang Y; Zhou F
    Biosens Bioelectron; 2013 Dec; 50():224-8. PubMed ID: 23867352
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase.
    Scholefield Z; Yates EA; Wayne G; Amour A; McDowell W; Turnbull JE
    J Cell Biol; 2003 Oct; 163(1):97-107. PubMed ID: 14530380
    [TBL] [Abstract][Full Text] [Related]  

  • 9. L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases β-amyloid peptide production in HEK293-APPswe cells.
    Lu Q; Chen WY; Zhu ZY; Chen J; Xu YC; Kaewpet M; Rukachaisirikul V; Chen LL; Shen X
    Acta Pharmacol Sin; 2012 Dec; 33(12):1459-68. PubMed ID: 22842730
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.
    Yang HC; Chai X; Mosior M; Kohn W; Boggs LN; Erickson JA; McClure DB; Yeh WK; Zhang L; Gonzalez-DeWhitt P; Mayer JP; Martin JA; Hu J; Chen SH; Bueno AB; Little SP; McCarthy JR; May PC
    J Neurochem; 2004 Dec; 91(6):1249-59. PubMed ID: 15584902
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dual Signal Amplification Electrochemical Biosensor for Monitoring the Activity and Inhibition of the Alzheimer's Related Protease β-Secretase.
    Qu F; Yang M; Rasooly A
    Anal Chem; 2016 Nov; 88(21):10559-10565. PubMed ID: 27650354
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inkjet printing-based β-secretase fluorescence resonance energy transfer (FRET) assay for screening of potential β-secretase inhibitors of Alzheimer's disease.
    Lee J; Samson AAS; Song JM
    Anal Chim Acta; 2018 Aug; 1022():89-95. PubMed ID: 29729742
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
    Li S; Hou H; Mori T; Sawmiller D; Smith A; Tian J; Wang Y; Giunta B; Sanberg PR; Zhang S; Tan J
    Sci Rep; 2015 Jun; 5():11322. PubMed ID: 26091071
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription.
    Li Y; Zhou W; Tong Y; He G; Song W
    FASEB J; 2006 Feb; 20(2):285-92. PubMed ID: 16449801
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer's Disease Cell Model.
    Liang H; Shi Y; Kou Z; Peng Y; Chen W; Li X; Li S; Wang Y; Wang F; Zhang X
    PLoS One; 2015; 10(10):e0140733. PubMed ID: 26473367
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Establishing the relationship between in vitro potency, pharmacokinetic, and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived β-secretase inhibitors.
    Wood S; Wen PH; Zhang J; Zhu L; Luo Y; Babu-Khan S; Chen K; Pham R; Esmay J; Dineen TA; Kaller MR; Weiss MM; Hitchcock SA; Citron M; Zhong W; Hickman D; Williamson T
    J Pharmacol Exp Ther; 2012 Nov; 343(2):460-7. PubMed ID: 22911925
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo.
    Atwal JK; Chen Y; Chiu C; Mortensen DL; Meilandt WJ; Liu Y; Heise CE; Hoyte K; Luk W; Lu Y; Peng K; Wu P; Rouge L; Zhang Y; Lazarus RA; Scearce-Levie K; Wang W; Wu Y; Tessier-Lavigne M; Watts RJ
    Sci Transl Med; 2011 May; 3(84):84ra43. PubMed ID: 21613622
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A peptide-WS
    Zuo X; Dai H; Zhang H; Liu J; Ma S; Chen X
    Analyst; 2018 Sep; 143(19):4585-4591. PubMed ID: 30156585
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regulation of proBACE1 by glycosaminoglycans.
    Small DH; Klaver DW; Beckman M
    Neurodegener Dis; 2008; 5(3-4):206-8. PubMed ID: 18322391
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.