135 related articles for article (PubMed ID: 12851038)
1. In vitro inhibition of human small intestinal and liver microsomal astemizole O-demethylation: different contribution of CYP2J2 in the small intestine and liver.
Matsumoto S; Hirama T; Kim HJ; Nagata K; Yamazoe Y
Xenobiotica; 2003 Jun; 33(6):615-23. PubMed ID: 12851038
[TBL] [Abstract][Full Text] [Related]
2. Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole.
Matsumoto S; Hirama T; Matsubara T; Nagata K; Yamazoe Y
Drug Metab Dispos; 2002 Nov; 30(11):1240-5. PubMed ID: 12386130
[TBL] [Abstract][Full Text] [Related]
3. Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
Lee CA; Jones JP; Katayama J; Kaspera R; Jiang Y; Freiwald S; Smith E; Walker GS; Totah RA
Drug Metab Dispos; 2012 May; 40(5):943-51. PubMed ID: 22328583
[TBL] [Abstract][Full Text] [Related]
4. Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes.
Hashizume T; Imaoka S; Mise M; Terauchi Y; Fujii T; Miyazaki H; Kamataki T; Funae Y
J Pharmacol Exp Ther; 2002 Jan; 300(1):298-304. PubMed ID: 11752129
[TBL] [Abstract][Full Text] [Related]
5. Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine.
Matsumoto S; Yamazoe Y
Br J Clin Pharmacol; 2001 Feb; 51(2):133-42. PubMed ID: 11259984
[TBL] [Abstract][Full Text] [Related]
6. Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism.
Fitzsimmons ME; Collins JM
Drug Metab Dispos; 1997 Feb; 25(2):256-66. PubMed ID: 9029057
[TBL] [Abstract][Full Text] [Related]
7. Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine.
Uehara S; Uno Y; Inoue T; Okamoto E; Sasaki E; Yamazaki H
Xenobiotica; 2016 Nov; 46(11):977-85. PubMed ID: 26899760
[TBL] [Abstract][Full Text] [Related]
8. Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations.
Yamazaki H; Okayama A; Imai N; Guengerich FP; Shimizu M
Xenobiotica; 2006 Dec; 36(12):1201-9. PubMed ID: 17162467
[TBL] [Abstract][Full Text] [Related]
9. Danazol Inhibits Cytochrome P450 2J2 Activity in a Substrate-independent Manner.
Lee E; Wu Z; Shon JC; Liu KH
Drug Metab Dispos; 2015 Aug; 43(8):1250-3. PubMed ID: 26048912
[TBL] [Abstract][Full Text] [Related]
10. Terfenadone is a strong inhibitor of CYP2J2 present in the human liver and intestinal microsomes.
Lee E; Kim JH; Shon JC; Wu Z; Kim HJ; Gim M; Lee T; Liu KH
Drug Metab Pharmacokinet; 2018 Jun; 33(3):159-163. PubMed ID: 29759885
[TBL] [Abstract][Full Text] [Related]
11. Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.
Yumibe N; Huie K; Chen KJ; Snow M; Clement RP; Cayen MN
Biochem Pharmacol; 1996 Jan; 51(2):165-72. PubMed ID: 8615885
[TBL] [Abstract][Full Text] [Related]
12. The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation.
Park SH; Lee J; Shon JC; Phuc NM; Jee JG; Liu KH
Phytomedicine; 2018 Mar; 42():199-206. PubMed ID: 29655687
[TBL] [Abstract][Full Text] [Related]
13. Identification of novel substrates for human cytochrome P450 2J2.
Lee CA; Neul D; Clouser-Roche A; Dalvie D; Wester MR; Jiang Y; Jones JP; Freiwald S; Zientek M; Totah RA
Drug Metab Dispos; 2010 Feb; 38(2):347-56. PubMed ID: 19923256
[TBL] [Abstract][Full Text] [Related]
14. Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability.
Lampen A; Christians U; Guengerich FP; Watkins PB; Kolars JC; Bader A; Gonschior AK; Dralle H; Hackbarth I; Sewing KF
Drug Metab Dispos; 1995 Dec; 23(12):1315-24. PubMed ID: 8689938
[TBL] [Abstract][Full Text] [Related]
15. Metabolism of epinastine, a histamine H1 receptor antagonist, in human liver microsomes in comparison with that of terfenadine.
Kishimoto W; Hiroi T; Sakai K; Funae Y; Igarashi T
Res Commun Mol Pathol Pharmacol; 1997 Dec; 98(3):273-92. PubMed ID: 9485522
[TBL] [Abstract][Full Text] [Related]
16. Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic cell death in hepatocellular carcinoma HepG2 cells.
Jeon YJ; Kim JS; Hwang GH; Wu Z; Han HJ; Park SH; Chang W; Kim LK; Lee YM; Liu KH; Lee MY
Eur J Pharmacol; 2015 Oct; 764():480-488. PubMed ID: 26209360
[TBL] [Abstract][Full Text] [Related]
17. Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A.
Liu KH; Kim MG; Lee DJ; Yoon YJ; Kim MJ; Shon JH; Choi CS; Choi YK; Desta Z; Shin JG
Drug Metab Dispos; 2006 Nov; 34(11):1793-7. PubMed ID: 16896065
[TBL] [Abstract][Full Text] [Related]
18. Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme.
Lu J; Liu D; Zhou X; Chen A; Jiang Z; Ye X; Liu M; Wang X
Phytomedicine; 2018 Jan; 39():137-145. PubMed ID: 29433675
[TBL] [Abstract][Full Text] [Related]
19. Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans.
Taniguchi-Takizawa T; Shimizu M; Kume T; Yamazaki H
Drug Metab Pharmacokinet; 2015 Feb; 30(1):64-9. PubMed ID: 25760531
[TBL] [Abstract][Full Text] [Related]
20. Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity.
Lee SS; Jeong HE; Liu KH; Ryu JY; Moon T; Yoon CN; Oh SJ; Yun CH; Shin JG
Pharmacogenet Genomics; 2005 Feb; 15(2):105-13. PubMed ID: 15861034
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
