These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

687 related articles for article (PubMed ID: 12852755)

  • 1. l-2',3'-Didehydro-2',3'-dideoxy-3'-fluoronucleosides: synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance.
    Chong Y; Gumina G; Mathew JS; Schinazi RF; Chu CK
    J Med Chem; 2003 Jul; 46(15):3245-56. PubMed ID: 12852755
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2',3'-didehydro-2',3'-dideoxy-2'-fluorocarbocyclic nucleosides.
    Wang J; Jin Y; Rapp KL; Bennett M; Schinazi RF; Chu CK
    J Med Chem; 2005 Jun; 48(11):3736-48. PubMed ID: 15916425
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.
    Choo H; Chong Y; Choi Y; Mathew J; Schinazi RF; Chu CK
    J Med Chem; 2003 Jan; 46(3):389-98. PubMed ID: 12540238
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis, structure-activity relationships, and mechanism of drug resistance of D- and L-beta-3'-fluoro-2',3'-unsaturated-4'-thionucleosides as anti-HIV agents.
    Zhu W; Chong Y; Choo H; Mathews J; Schinazi RF; Chu CK
    J Med Chem; 2004 Mar; 47(7):1631-40. PubMed ID: 15027854
    [TBL] [Abstract][Full Text] [Related]  

  • 5. D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance.
    Wang J; Jin Y; Rapp KL; Schinazi RF; Chu CK
    J Med Chem; 2007 Apr; 50(8):1828-39. PubMed ID: 17373782
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, structure-activity relationships, and drug resistance of beta-d-3'-fluoro-2',3'-unsaturated nucleosides as anti-HIV Agents.
    Zhou W; Gumina G; Chong Y; Wang J; Schinazi RF; Chu CK
    J Med Chem; 2004 Jun; 47(13):3399-408. PubMed ID: 15189036
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular mechanism of dioxolane nucleosides against 3TC resistant M184V mutant HIV.
    Chong Y; Chu CK
    Antiviral Res; 2004 Jul; 63(1):7-13. PubMed ID: 15196815
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 2'-Fluoro-4'-thio-2',3'-unsaturated nucleosides: anti-HIV activity, resistance profile, and molecular modeling studies.
    Chong Y; Choo H; Schinazi RF; Chu CK
    Nucleosides Nucleotides Nucleic Acids; 2003; 22(5-8):611-5. PubMed ID: 14565238
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.
    Chong Y; Choo H; Choi Y; Mathew J; Schinazi RF; Chu CK
    J Med Chem; 2002 Oct; 45(22):4888-98. PubMed ID: 12383014
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
    Shi J; McAtee JJ; Schlueter Wirtz S; Tharnish P; Juodawlkis A; Liotta DC; Schinazi RF
    J Med Chem; 1999 Mar; 42(5):859-67. PubMed ID: 10072683
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of 2',3'-unsaturation on the antiviral activity of anti-HIV nucleosides against 3TC-resistant mutant (M184V).
    Choo H; Chong Y; Chu CK
    Bioorg Med Chem Lett; 2003 Jun; 13(12):1993-6. PubMed ID: 12781181
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2', 3'-unsaturated L-nucleosides.
    Lee K; Choi Y; Gullen E; Schlueter-Wirtz S; Schinazi RF; Cheng YC; Chu CK
    J Med Chem; 1999 Apr; 42(7):1320-8. PubMed ID: 10197975
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates.
    Mackman RL; Boojamra CG; Prasad V; Zhang L; Lin KY; Petrakovsky O; Babusis D; Chen J; Douglas J; Grant D; Hui HC; Kim CU; Markevitch DY; Vela J; Ray A; Cihlar T
    Bioorg Med Chem Lett; 2007 Dec; 17(24):6785-9. PubMed ID: 18029175
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Interaction of beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluoro-CTP with human immunodeficiency virus-1 reverse transcriptase and human DNA polymerases: implications for human immunodeficiency virus drug design.
    Kukhanova M; Li X; Chen SH; King I; Doyle T; Prusoff W; Cheng YC
    Mol Pharmacol; 1998 May; 53(5):801-7. PubMed ID: 9584205
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and anti-HIV activity of GS-9148 (2'-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor.
    Boojamra CG; Mackman RL; Markevitch DY; Prasad V; Ray AS; Douglas J; Grant D; Kim CU; Cihlar T
    Bioorg Med Chem Lett; 2008 Feb; 18(3):1120-3. PubMed ID: 18164198
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase.
    Velázquez S; Chamorro C; Pérez-Pérez MJ; Alvarez R; Jimeno ML; Martín-Domenech A; Pérez C; Gago F; De Clercq E; Balzarini J; San-Félix A; Camarasa MJ
    J Med Chem; 1998 Nov; 41(23):4636-47. PubMed ID: 9804703
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family.
    Mai A; Artico M; Ragno R; Sbardella G; Massa S; Musiu C; Mura M; Marturana F; Cadeddu A; Maga G; La Colla P
    Bioorg Med Chem; 2005 Mar; 13(6):2065-77. PubMed ID: 15727860
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors.
    Boojamra CG; Parrish JP; Sperandio D; Gao Y; Petrakovsky OV; Lee SK; Markevitch DY; Vela JE; Laflamme G; Chen JM; Ray AS; Barron AC; Sparacino ML; Desai MC; Kim CU; Cihlar T; Mackman RL
    Bioorg Med Chem; 2009 Feb; 17(4):1739-46. PubMed ID: 19179082
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Computer-aided design, synthesis, and anti-HIV-1 activity in vitro of 2-alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as novel potent non-nucleoside reverse transcriptase inhibitors, also active against the Y181C variant.
    Ragno R; Mai A; Sbardella G; Artico M; Massa S; Musiu C; Mura M; Marturana F; Cadeddu A; La Colla P
    J Med Chem; 2004 Feb; 47(4):928-34. PubMed ID: 14761194
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Asymmetric synthesis and antiviral activities of L-carbocyclic 2', 3'-didehydro-2',3'-dideoxy and 2',3'-dideoxy nucleosides.
    Wang P; Gullen B; Newton MG; Cheng YC; Schinazi RF; Chu CK
    J Med Chem; 1999 Aug; 42(17):3390-9. PubMed ID: 10464025
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 35.