BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

204 related articles for article (PubMed ID: 12857387)

  • 1. High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition.
    Gottlin EB; Benson RE; Conary S; Antonio B; Duke K; Payne ES; Ashraf SS; Christensen DJ
    J Biomol Screen; 2003 Jun; 8(3):332-9. PubMed ID: 12857387
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A high-throughput screening assay for simultaneous selection of inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate synthase (Dxs) or 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr).
    Humnabadkar V; Jha RK; Ghatnekar N; De Sousa SM
    J Biomol Screen; 2011 Mar; 16(3):303-12. PubMed ID: 21335601
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview.
    Proteau PJ
    Bioorg Chem; 2004 Dec; 32(6):483-93. PubMed ID: 15530989
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.
    Giessmann D; Heidler P; Haemers T; Van Calenbergh S; Reichenberg A; Jomaa H; Weidemeyer C; Sanderbrand S; Wiesner J; Link A
    Chem Biodivers; 2008 Apr; 5(4):643-56. PubMed ID: 18421757
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
    Mercklé L; de Andrés-Gómez A; Dick B; Cox RJ; Godfrey CR
    Chembiochem; 2005 Oct; 6(10):1866-74. PubMed ID: 16116659
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
    Woo YH; Fernandes RP; Proteau PJ
    Bioorg Med Chem; 2006 Apr; 14(7):2375-85. PubMed ID: 16310360
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and analysis of a fluorinated product analogue as an inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
    Munos JW; Pu X; Liu HW
    Bioorg Med Chem Lett; 2008 May; 18(10):3090-4. PubMed ID: 18078746
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Isoprenoid biosynthesis via the methylerythritol phosphate pathway: structural variations around phosphonate anchor and spacer of fosmidomycin, a potent inhibitor of deoxyxylulose phosphate reductoisomerase.
    Zinglé C; Kuntz L; Tritsch D; Grosdemange-Billiard C; Rohmer M
    J Org Chem; 2010 May; 75(10):3203-7. PubMed ID: 20429517
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum.
    Singh VK; Ghosh I
    FEBS Lett; 2013 Sep; 587(17):2806-17. PubMed ID: 23816706
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Substrate analogs for the investigation of deoxyxylulose 5-phosphate reductoisomerase inhibition: synthesis and evaluation.
    Phaosiri C; Proteau PJ
    Bioorg Med Chem Lett; 2004 Nov; 14(21):5309-12. PubMed ID: 15454217
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes.
    Yajima S; Hara K; Sanders JM; Yin F; Ohsawa K; Wiesner J; Jomaa H; Oldfield E
    J Am Chem Soc; 2004 Sep; 126(35):10824-5. PubMed ID: 15339150
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
    Mac Sweeney A; Lange R; Fernandes RP; Schulz H; Dale GE; Douangamath A; Proteau PJ; Oefner C
    J Mol Biol; 2005 Jan; 345(1):115-27. PubMed ID: 15567415
    [TBL] [Abstract][Full Text] [Related]  

  • 13. NMR studies of DOXP reductoisomerase and its inhibitor complex.
    Englert NE; Richter C; Wiesner J; Hintz M; Jomaa H; Schwalbe H
    Chembiochem; 2011 Feb; 12(3):468-76. PubMed ID: 21290548
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel deoxyxylulosephosphate-reductoisomerase inhibitors: fosmidomycin derivatives with spacious acyl residues.
    Ortmann R; Wiesner J; Silber K; Klebe G; Jomaa H; Schlitzer M
    Arch Pharm (Weinheim); 2007 Sep; 340(9):483-90. PubMed ID: 17806130
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and evaluation of alpha,beta-unsaturated alpha-aryl-substituted fosmidomycin analogues as DXR inhibitors.
    Devreux V; Wiesner J; Jomaa H; Van der Eycken J; Van Calenbergh S
    Bioorg Med Chem Lett; 2007 Sep; 17(17):4920-3. PubMed ID: 17583502
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme.
    Singh N; Chevé G; Avery MA; McCurdy CR
    Curr Pharm Des; 2007; 13(11):1161-77. PubMed ID: 17430177
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target.
    Henriksson LM; Björkelid C; Mowbray SL; Unge T
    Acta Crystallogr D Biol Crystallogr; 2006 Jul; 62(Pt 7):807-13. PubMed ID: 16790937
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding.
    Takenoya M; Ohtaki A; Noguchi K; Endo K; Sasaki Y; Ohsawa K; Yajima S; Yohda M
    J Struct Biol; 2010 Jun; 170(3):532-9. PubMed ID: 20353826
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Studies addressing the importance of charge in the binding of fosmidomycin-like molecules to deoxyxylulosephosphate reductoisomerase.
    Perruchon J; Ortmann R; Altenkämper M; Silber K; Wiesner J; Jomaa H; Klebe G; Schlitzer M
    ChemMedChem; 2008 Aug; 3(8):1232-41. PubMed ID: 18470849
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase.
    Kuntz L; Tritsch D; Grosdemange-Billiard C; Hemmerlin A; Willem A; Bach TJ; Rohmer M
    Biochem J; 2005 Feb; 386(Pt 1):127-35. PubMed ID: 15473867
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.