BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

150 related articles for article (PubMed ID: 12857759)

  • 1. Characterization of the ectodomain shedding of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
    Hussain I; Hawkins J; Shikotra A; Riddell DR; Faller A; Dingwall C
    J Biol Chem; 2003 Sep; 278(38):36264-8. PubMed ID: 12857759
    [TBL] [Abstract][Full Text] [Related]  

  • 2. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.
    Sala Frigerio C; Fadeeva JV; Minogue AM; Citron M; Van Leuven F; Staufenbiel M; Paganetti P; Selkoe DJ; Walsh DM
    FEBS J; 2010 Mar; 277(6):1503-18. PubMed ID: 20163459
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1.
    Qahwash I; He W; Tomasselli A; Kletzien RF; Yan R
    J Biol Chem; 2004 Sep; 279(37):39010-6. PubMed ID: 15234966
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 5. BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis.
    Zhang S; Wang Z; Cai F; Zhang M; Wu Y; Zhang J; Song W
    J Neurosci; 2017 Jul; 37(29):6915-6925. PubMed ID: 28626014
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.
    Shi XP; Tugusheva K; Bruce JE; Lucka A; Wu GX; Chen-Dodson E; Price E; Li Y; Xu M; Huang Q; Sardana MK; Hazuda DJ
    J Biol Chem; 2003 Jun; 278(23):21286-94. PubMed ID: 12665519
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Employing a superior BACE1 cleavage sequence to probe cellular APP processing.
    Tomasselli AG; Qahwash I; Emmons TL; Lu Y; Leone JW; Lull JM; Fok KF; Bannow CA; Smith CW; Bienkowski MJ; Heinrikson RL; Yan R
    J Neurochem; 2003 Mar; 84(5):1006-17. PubMed ID: 12603825
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Camelid heavy chain only antibody fragment domain against β-site of amyloid precursor protein cleaving enzyme 1 inhibits β-secretase activity in vitro and in vivo.
    Dorresteijn B; Rotman M; Faber D; Schravesande R; Suidgeest E; van der Weerd L; van der Maarel SM; Verrips CT; El Khattabi M
    FEBS J; 2015 Sep; 282(18):3618-31. PubMed ID: 26147692
    [TBL] [Abstract][Full Text] [Related]  

  • 9. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
    Lefranc-Jullien S; Sunyach C; Checler F
    J Neurochem; 2006 May; 97(3):807-17. PubMed ID: 16524370
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
    Kimura A; Hata S; Suzuki T
    J Biol Chem; 2016 Nov; 291(46):24041-24053. PubMed ID: 27687728
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Extracellular release of BACE1 holoproteins from human neuronal cells.
    Murayama KS; Kametani F; Araki W
    Biochem Biophys Res Commun; 2005 Dec; 338(2):800-7. PubMed ID: 16243299
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate.
    Yan R; Han P; Miao H; Greengard P; Xu H
    J Biol Chem; 2001 Sep; 276(39):36788-96. PubMed ID: 11466313
    [TBL] [Abstract][Full Text] [Related]  

  • 13. BACE1 gene expression and protein degradation.
    Zhou W; Qing H; Tong Y; Song W
    Ann N Y Acad Sci; 2004 Dec; 1035():49-67. PubMed ID: 15681800
    [TBL] [Abstract][Full Text] [Related]  

  • 14. BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors.
    Andrau D; Dumanchin-Njock C; Ayral E; Vizzavona J; Farzan M; Boisbrun M; Fulcrand P; Hernandez JF; Martinez J; Lefranc-Jullien S; Checler F
    J Biol Chem; 2003 Jul; 278(28):25859-66. PubMed ID: 12736275
    [TBL] [Abstract][Full Text] [Related]  

  • 15. beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase.
    Wong HK; Sakurai T; Oyama F; Kaneko K; Wada K; Miyazaki H; Kurosawa M; De Strooper B; Saftig P; Nukina N
    J Biol Chem; 2005 Jun; 280(24):23009-17. PubMed ID: 15824102
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting.
    John BA; Meister M; Banning A; Tikkanen R
    FEBS J; 2014 Apr; 281(8):2074-87. PubMed ID: 24612608
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.
    Sun X; Wang Y; Qing H; Christensen MA; Liu Y; Zhou W; Tong Y; Xiao C; Huang Y; Zhang S; Liu X; Song W
    FASEB J; 2005 May; 19(7):739-49. PubMed ID: 15857888
    [TBL] [Abstract][Full Text] [Related]  

  • 18. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
    Meredith JE; Thompson LA; Toyn JH; Marcin L; Barten DM; Marcinkeviciene J; Kopcho L; Kim Y; Lin A; Guss V; Burton C; Iben L; Polson C; Cantone J; Ford M; Drexler D; Fiedler T; Lentz KA; Grace JE; Kolb J; Corsa J; Pierdomenico M; Jones K; Olson RE; Macor JE; Albright CF
    J Pharmacol Exp Ther; 2008 Aug; 326(2):502-13. PubMed ID: 18499745
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding.
    Parvathy S; Ehrlich M; Pedrini S; Diaz N; Refolo L; Buxbaum JD; Bogush A; Petanceska S; Gandy S
    J Neurochem; 2004 Aug; 90(4):1005-10. PubMed ID: 15287907
    [TBL] [Abstract][Full Text] [Related]  

  • 20. BACE1: the beta-secretase enzyme in Alzheimer's disease.
    Vassar R
    J Mol Neurosci; 2004; 23(1-2):105-14. PubMed ID: 15126696
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.