BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

322 related articles for article (PubMed ID: 12867426)

  • 1. Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin.
    Tee AR; Anjum R; Blenis J
    J Biol Chem; 2003 Sep; 278(39):37288-96. PubMed ID: 12867426
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
    Tee AR; Fingar DC; Manning BD; Kwiatkowski DJ; Cantley LC; Blenis J
    Proc Natl Acad Sci U S A; 2002 Oct; 99(21):13571-6. PubMed ID: 12271141
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
    Tee AR; Manning BD; Roux PP; Cantley LC; Blenis J
    Curr Biol; 2003 Aug; 13(15):1259-68. PubMed ID: 12906785
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
    Roux PP; Ballif BA; Anjum R; Gygi SP; Blenis J
    Proc Natl Acad Sci U S A; 2004 Sep; 101(37):13489-94. PubMed ID: 15342917
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Tumour suppressors hamartin and tuberin: intracellular signalling.
    Krymskaya VP
    Cell Signal; 2003 Aug; 15(8):729-39. PubMed ID: 12781866
    [TBL] [Abstract][Full Text] [Related]  

  • 6. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
    Inoki K; Li Y; Zhu T; Wu J; Guan KL
    Nat Cell Biol; 2002 Sep; 4(9):648-57. PubMed ID: 12172553
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin.
    Dan HC; Sun M; Yang L; Feldman RI; Sui XM; Ou CC; Nellist M; Yeung RS; Halley DJ; Nicosia SV; Pledger WJ; Cheng JQ
    J Biol Chem; 2002 Sep; 277(38):35364-70. PubMed ID: 12167664
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent.
    Jaeschke A; Hartkamp J; Saitoh M; Roworth W; Nobukuni T; Hodges A; Sampson J; Thomas G; Lamb R
    J Cell Biol; 2002 Oct; 159(2):217-24. PubMed ID: 12403809
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Regulation of tuberous sclerosis complex (TSC) function by 14-3-3 proteins.
    Nellist M; Goedbloed MA; Halley DJ
    Biochem Soc Trans; 2003 Jun; 31(Pt 3):587-91. PubMed ID: 12773161
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
    Manning BD; Tee AR; Logsdon MN; Blenis J; Cantley LC
    Mol Cell; 2002 Jul; 10(1):151-62. PubMed ID: 12150915
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM).
    Goncharova EA; Goncharov DA; Eszterhas A; Hunter DS; Glassberg MK; Yeung RS; Walker CL; Noonan D; Kwiatkowski DJ; Chou MM; Panettieri RA; Krymskaya VP
    J Biol Chem; 2002 Aug; 277(34):30958-67. PubMed ID: 12045200
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.
    Shi Y; Hsu JH; Hu L; Gera J; Lichtenstein A
    J Biol Chem; 2002 May; 277(18):15712-20. PubMed ID: 11872747
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.
    Karbowniczek M; Cash T; Cheung M; Robertson GP; Astrinidis A; Henske EP
    J Biol Chem; 2004 Jul; 279(29):29930-7. PubMed ID: 15150271
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions.
    Han S; Santos TM; Puga A; Roy J; Thiele EA; McCollin M; Stemmer-Rachamimov A; Ramesh V
    Cancer Res; 2004 Feb; 64(3):812-6. PubMed ID: 14871804
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells.
    Herbert TP; Kilhams GR; Batty IH; Proud CG
    J Biol Chem; 2000 Apr; 275(15):11249-56. PubMed ID: 10753934
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin.
    Shumway SD; Li Y; Xiong Y
    J Biol Chem; 2003 Jan; 278(4):2089-92. PubMed ID: 12468542
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy.
    Valianou M; Cox AM; Pichette B; Hartley S; Paladhi UR; Astrinidis A
    Cell Cycle; 2015; 14(3):399-407. PubMed ID: 25565629
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
    Li Y; Inoki K; Vacratsis P; Guan KL
    J Biol Chem; 2003 Apr; 278(16):13663-71. PubMed ID: 12582162
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation.
    Dufner A; Andjelkovic M; Burgering BM; Hemmings BA; Thomas G
    Mol Cell Biol; 1999 Jun; 19(6):4525-34. PubMed ID: 10330191
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.
    Gingras AC; Kennedy SG; O'Leary MA; Sonenberg N; Hay N
    Genes Dev; 1998 Feb; 12(4):502-13. PubMed ID: 9472019
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.