724 related articles for article (PubMed ID: 12869565)
1. Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.
Lu Y; Yu Q; Liu JH; Zhang J; Wang H; Koul D; McMurray JS; Fang X; Yung WK; Siminovitch KA; Mills GB
J Biol Chem; 2003 Oct; 278(41):40057-66. PubMed ID: 12869565
[TBL] [Abstract][Full Text] [Related]
2. PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.
Choi Y; Zhang J; Murga C; Yu H; Koller E; Monia BP; Gutkind JS; Li W
Oncogene; 2002 Aug; 21(34):5289-300. PubMed ID: 12149650
[TBL] [Abstract][Full Text] [Related]
3. The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors.
Wu CJ; O'Rourke DM; Feng GS; Johnson GR; Wang Q; Greene MI
Oncogene; 2001 Sep; 20(42):6018-25. PubMed ID: 11593409
[TBL] [Abstract][Full Text] [Related]
4. PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.
Tang X; Powelka AM; Soriano NA; Czech MP; Guilherme A
J Biol Chem; 2005 Jun; 280(23):22523-9. PubMed ID: 15824124
[TBL] [Abstract][Full Text] [Related]
5. Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins.
Welsh N; Makeeva N; Welsh M
Mol Med; 2002 Nov; 8(11):695-704. PubMed ID: 12520086
[TBL] [Abstract][Full Text] [Related]
6. PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway.
Weng LP; Brown JL; Baker KM; Ostrowski MC; Eng C
Hum Mol Genet; 2002 Jul; 11(15):1687-96. PubMed ID: 12095911
[TBL] [Abstract][Full Text] [Related]
7. Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways.
Gu J; Tamura M; Yamada KM
J Cell Biol; 1998 Nov; 143(5):1375-83. PubMed ID: 9832564
[TBL] [Abstract][Full Text] [Related]
8. The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells.
Asano T; Yao Y; Zhu J; Li D; Abbruzzese JL; Reddy SA
Oncogene; 2004 Nov; 23(53):8571-80. PubMed ID: 15467756
[TBL] [Abstract][Full Text] [Related]
9. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
Ozes ON; Akca H; Mayo LD; Gustin JA; Maehama T; Dixon JE; Donner DB
Proc Natl Acad Sci U S A; 2001 Apr; 98(8):4640-5. PubMed ID: 11287630
[TBL] [Abstract][Full Text] [Related]
10. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.
Ramaswamy S; Nakamura N; Vazquez F; Batt DB; Perera S; Roberts TM; Sellers WR
Proc Natl Acad Sci U S A; 1999 Mar; 96(5):2110-5. PubMed ID: 10051603
[TBL] [Abstract][Full Text] [Related]
11. Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase.
Mahimainathan L; Choudhury GG
J Biol Chem; 2004 Apr; 279(15):15258-68. PubMed ID: 14718524
[TBL] [Abstract][Full Text] [Related]
12. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.
Nagata Y; Lan KH; Zhou X; Tan M; Esteva FJ; Sahin AA; Klos KS; Li P; Monia BP; Nguyen NT; Hortobagyi GN; Hung MC; Yu D
Cancer Cell; 2004 Aug; 6(2):117-27. PubMed ID: 15324695
[TBL] [Abstract][Full Text] [Related]
13. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
Haas-Kogan D; Shalev N; Wong M; Mills G; Yount G; Stokoe D
Curr Biol; 1998 Oct; 8(21):1195-8. PubMed ID: 9799739
[TBL] [Abstract][Full Text] [Related]
14. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.
Freeburn RW; Wright KL; Burgess SJ; Astoul E; Cantrell DA; Ward SG
J Immunol; 2002 Nov; 169(10):5441-50. PubMed ID: 12421919
[TBL] [Abstract][Full Text] [Related]
15. Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt.
Hakak Y; Hsu YS; Martin GS
Oncogene; 2000 Jun; 19(28):3164-71. PubMed ID: 10918571
[TBL] [Abstract][Full Text] [Related]
16. Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2.
Song K; Cornelius SC; Reiss M; Danielpour D
J Biol Chem; 2003 Oct; 278(40):38342-51. PubMed ID: 12876289
[TBL] [Abstract][Full Text] [Related]
17. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.
Shan X; Czar MJ; Bunnell SC; Liu P; Liu Y; Schwartzberg PL; Wange RL
Mol Cell Biol; 2000 Sep; 20(18):6945-57. PubMed ID: 10958690
[TBL] [Abstract][Full Text] [Related]
18. Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.
Knobbe CB; Reifenberger G
Brain Pathol; 2003 Oct; 13(4):507-18. PubMed ID: 14655756
[TBL] [Abstract][Full Text] [Related]
19. SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity.
Cuevas B; Lu Y; Watt S; Kumar R; Zhang J; Siminovitch KA; Mills GB
J Biol Chem; 1999 Sep; 274(39):27583-9. PubMed ID: 10488096
[TBL] [Abstract][Full Text] [Related]
20. Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.
St-Germain ME; Gagnon V; Mathieu I; Parent S; Asselin E
Int J Oncol; 2004 May; 24(5):1311-24. PubMed ID: 15067356
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
