207 related articles for article (PubMed ID: 12888552)
1. Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme.
Huynh TT; Huynh VT; Harmon MA; Phillips MA
J Biol Chem; 2003 Oct; 278(41):39794-800. PubMed ID: 12888552
[TBL] [Abstract][Full Text] [Related]
2. Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi.
Vázquez C; Mejia-Tlachi M; González-Chávez Z; Silva A; Rodríguez-Zavala JS; Moreno-Sánchez R; Saavedra E
FEBS Lett; 2017 Dec; 591(23):3881-3894. PubMed ID: 29127710
[TBL] [Abstract][Full Text] [Related]
3. Characterization of Trypanosoma brucei gamma-glutamylcysteine synthetase, an essential enzyme in the biosynthesis of trypanothione (diglutathionylspermidine).
Lueder DV; Phillips MA
J Biol Chem; 1996 Jul; 271(29):17485-90. PubMed ID: 8663359
[TBL] [Abstract][Full Text] [Related]
4. Trypanosoma brucei gamma-glutamylcysteine synthetase. Characterization of the kinetic mechanism and the role of Cys-319 in cystamine inactivation.
Brekken DL; Phillips MA
J Biol Chem; 1998 Oct; 273(41):26317-22. PubMed ID: 9756861
[TBL] [Abstract][Full Text] [Related]
5. Validation of Trypanosoma brucei trypanothione synthetase as drug target.
Comini MA; Guerrero SA; Haile S; Menge U; Lünsdorf H; Flohé L
Free Radic Biol Med; 2004 May; 36(10):1289-302. PubMed ID: 15110394
[TBL] [Abstract][Full Text] [Related]
6. RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.
Xiao Y; McCloskey DE; Phillips MA
Eukaryot Cell; 2009 May; 8(5):747-55. PubMed ID: 19304951
[TBL] [Abstract][Full Text] [Related]
7. Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome.
Ariyanayagam MR; Oza SL; Guther ML; Fairlamb AH
Biochem J; 2005 Oct; 391(Pt 2):425-32. PubMed ID: 16008527
[TBL] [Abstract][Full Text] [Related]
8. Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei.
Shahi SK; Krauth-Siegel RL; Clayton CE
Mol Microbiol; 2002 Mar; 43(5):1129-38. PubMed ID: 11918801
[TBL] [Abstract][Full Text] [Related]
9. Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei.
Zimmermann S; Oufir M; Leroux A; Krauth-Siegel RL; Becker K; Kaiser M; Brun R; Hamburger M; Adams M
Bioorg Med Chem; 2013 Nov; 21(22):7202-9. PubMed ID: 24080104
[TBL] [Abstract][Full Text] [Related]
10. Glutathione homeostasis in human hepatic cells: overexpression of gamma-glutamylcysteine synthetase gene in cell lines resistant to buthionine sulfoximine, an inhibitor of glutathione synthesis.
Tanaka T; Uchiumi T; Kohno K; Tomonari A; Nishio K; Saijo N; Kondo T; Kuwano M
Biochem Biophys Res Commun; 1998 May; 246(2):398-403. PubMed ID: 9610371
[TBL] [Abstract][Full Text] [Related]
11. Variable baseline gamma-glutamylcysteine synthetase messenger RNA expression in peripheral mononuclear cells of cancer patients, and its induction by buthionine sulfoximine treatment.
Yao K; Godwin AK; Ozols RF; Hamilton TC; O'Dwyer PJ
Cancer Res; 1993 Aug; 53(16):3662-6. PubMed ID: 8101766
[TBL] [Abstract][Full Text] [Related]
12. Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity.
González-Chávez Z; Vázquez C; Mejia-Tlachi M; Márquez-Dueñas C; Manning-Cela R; Encalada R; Rodríguez-Enríquez S; Michels PAM; Moreno-Sánchez R; Saavedra E
Redox Biol; 2019 Sep; 26():101231. PubMed ID: 31203195
[TBL] [Abstract][Full Text] [Related]
13. Regulation of gamma-glutamylcysteine synthetase subunit gene expression in retinal Müller cells by oxidative stress.
Lu SC; Bao Y; Huang ZZ; Sarthy VP; Kannan R
Invest Ophthalmol Vis Sci; 1999 Jul; 40(8):1776-82. PubMed ID: 10393048
[TBL] [Abstract][Full Text] [Related]
14. The gamma-glutamylcysteine synthetase of Onchocerca volvulus.
Lüersen K; Müller S; Hussein A; Liebau E; Walter RD
Mol Biochem Parasitol; 2000 Dec; 111(2):243-51. PubMed ID: 11163433
[TBL] [Abstract][Full Text] [Related]
15. Properties of trypanothione synthetase from Trypanosoma brucei.
Oza SL; Ariyanayagam MR; Aitcheson N; Fairlamb AH
Mol Biochem Parasitol; 2003 Sep; 131(1):25-33. PubMed ID: 12967709
[TBL] [Abstract][Full Text] [Related]
16. Glutathione and trypanothione in several strains of Trypanosoma cruzi: effect of drugs.
Repetto Y; Opazo E; Maya JD; Agosin M; Morello A
Comp Biochem Physiol B Biochem Mol Biol; 1996 Oct; 115(2):281-5. PubMed ID: 8939007
[TBL] [Abstract][Full Text] [Related]
17. Modulation of gamma-glutamylcysteine synthetase large subunit mRNA expression by butylated hydroxyanisole.
Borroz KI; Buetler TM; Eaton DL
Toxicol Appl Pharmacol; 1994 May; 126(1):150-5. PubMed ID: 7910420
[TBL] [Abstract][Full Text] [Related]
18. Markedly decreased expression of glutathione S-transferase pi gene in human cancer cell lines resistant to buthionine sulfoximine, an inhibitor of cellular glutathione synthesis.
Yokomizo A; Kohno K; Wada M; Ono M; Morrow CS; Cowan KH; Kuwano M
J Biol Chem; 1995 Aug; 270(33):19451-7. PubMed ID: 7642628
[TBL] [Abstract][Full Text] [Related]
19. Glutathione: an overview of biosynthesis and modulation.
Anderson ME
Chem Biol Interact; 1998 Apr; 111-112():1-14. PubMed ID: 9679538
[TBL] [Abstract][Full Text] [Related]
20. Glutathione synthesis in Streptococcus agalactiae. One protein accounts for gamma-glutamylcysteine synthetase and glutathione synthetase activities.
Janowiak BE; Griffith OW
J Biol Chem; 2005 Mar; 280(12):11829-39. PubMed ID: 15642737
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]